Human Recombinant UBE2R2 Active Protein – Cat# MBS845263

UBE2R2 (Ubc3b) (UBE2R2) Human Recombinant Active Protein

Name: UBE2R2 Active Protein; UBE2R2 (Ubc3b); Human Recombinant; MyBioSource
Brand: MyBioSource
SKU: MBS845263
Price: 450 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS845263

Background: UBE2R2 is a 238 amino acid (27.2 kDa) pre-protein from chromosome 9. After CK2-mediated UBE2R2 phosphorylation, it binds to the F-Box protein beta-TrCP, which is the subunit recognition subunit of an SCF E3 ligase. UBE2R2 may be involved in… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

UBE2R2 (Ubc3B), Active Protein

Full Product Name

Human recombinant UBE2R2 (Ubc3B)

Product Gene Name

UBE2R2 active protein

Product Synonym Names

Human recombinant UBE2R2 (Ubc3B); Cdc34b; Ubc3B; Ubiquitin-conjugating enzyme E2 R2Ubiquitin carrier protein R2; Ubiquitin-conjugating enzyme E2-CDC34B; Ubiquitin-protein ligase R2.

Form/Format

75 uL of a 40 uM solution (3 nmoles) in TBS.
Appearance: Liquid

Purity/Purification

>=95%

Preparation and Storage

At -80 degree C
Shelf Life: 12 months

Molecular Weight

27.166 kDa

OMIM

612506

3D Structure

ModBase 3D Structure for Q712K3

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Biological Activity

Protein concentration of 100 nM - 1 uM is recommended for in vitro conjugation.

Handling

Centrifuge the vial prior to opening.

Product Categories/Family for UBE2R2 active protein

Proteins and Enzymes; Proteins and Enzymes (A-Z) Diabetes; Obesity & Metabolic Syndrome; Signaling Pathways in Diabetes and Obesity; GSK-3/Wnt Signaling; Proteins/Enzymes

Applications Tested/Suitable for UBE2R2 active protein

RP-HPLC

Other Notes

Small volumes of UBE2R2 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for UBE2R2 purchase

MBS845263 is an active protein targeting UBE2R2. Also known as Human recombinant UBE2R2 (Ubc3B).

Additional Details

NCBI/Uniprot data below describe general gene information for UBE2R2. It may not necessarily be applicable to this product.

NCBI GI #

22212943

NCBI GeneID

54926

NCBI Accession #

NP_060281.2

UniProt Primary Accession #

Q712K3

UniProt Secondary Accession #

Q9NX64; D3DRL5

UniProt Related Accession #

Q712K3

GenBank Nucleotide #

NM_017811.3

NCBI Official Full Name

ubiquitin-conjugating enzyme E2 R2

NCBI Official Synonym Full Names

ubiquitin-conjugating enzyme E2R 2

NCBI Official Symbol

UBE2R2

NCBI Official Synonym Symbols

UBC3B; CDC34B; E2-CDC34B

UniProt Protein Name

Ubiquitin-conjugating enzyme E2 R2

UniProt Synonym Protein Names

Ubiquitin carrier protein R2; Ubiquitin-conjugating enzyme E2-CDC34B; Ubiquitin-protein ligase R2

Protein Family

Ubiquitin-conjugating enzyme

UniProt Gene Name

UBE2R2

UniProt Synonym Gene Names

CDC34B; UBC3B

UniProt Entry Name

UB2R2_HUMAN

NCBI Protein Information

ubiquitin-conjugating enzyme E2 R2

NCBI Summary for UBE2R2

Protein kinase CK2 is a ubiquitous and pleiotropic Ser/Thr protein kinase involved in cell growth and transformation. This gene encodes a protein similar to the E2 ubiquitin conjugating enzyme UBC3/CDC34. Studies suggest that CK2-dependent phosphorylation of this ubiquitin-conjugating enzyme functions by regulating beta-TrCP substrate recognition and induces its interaction with beta-TrCP, enhancing beta-catenin degradation. [provided by RefSeq, Jul 2008]

UniProt Comments for UBE2R2

UBC3B: an E2 ubiquitin conjugating enzyme similar to UBC3/CDC34. Phosphorylation of UBC3B by CK2 induces its interaction with beta-TrCP, regulating beta-TrCP substrate recognition and enhancing beta-catenin degradation.

Protein type: EC 6.3.2.19; Ubiquitin conjugating system; Ubiquitin ligase; Ligase

Chromosomal Location of Human Ortholog: 9p13.3

Cellular Component: cytoplasm

Molecular Function: small conjugating protein ligase activity; ubiquitin protein ligase binding; ubiquitin-protein ligase activity; ATP binding; ligase activity

Biological Process: protein monoubiquitination; proteasomal ubiquitin-dependent protein catabolic process

Research Articles on UBE2R2

1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with UBE2R2 active protein

Reference Product	PubMed Publications
UBA6 active protein	>1 publications with UBE2R2 and UBA6
SKP1 active protein	>1 publications with UBE2R2 and SKP1
CUL1 active protein	>1 publications with UBE2R2 and CUL1

Pathways associated with UBE2R2 active protein

Products by Pathway	Pathway Diagram
Adaptive Immune System Pathway antibodies	Adaptive Immune System Pathway Diagram
Antigen Processing: Ubiquitination & Proteasome Degradation Pathway antibodies	Antigen Processing: Ubiquitination & Proteasome Degradation Pathway Diagram
Class I MHC Mediated Antigen Processing & Presentation Pathway antibodies	Class I MHC Mediated Antigen Processing & Presentation Pathway Diagram
Herpes Simplex Infection Pathway antibodies	Herpes Simplex Infection Pathway Diagram
Herpes Simplex Infection Pathway antibodies	Herpes Simplex Infection Pathway Diagram
Immune System Pathway antibodies	Immune System Pathway Diagram
Ubiquitin Mediated Proteolysis Pathway antibodies	Ubiquitin Mediated Proteolysis Pathway Diagram
Ubiquitin Mediated Proteolysis Pathway antibodies	Ubiquitin Mediated Proteolysis Pathway Diagram
Protein Ubiquitylation Pathway antibodies	Protein Ubiquitylation Pathway Diagram

Organs/Tissues associated with UBE2R2 active protein

Organ/Tissue Name	Pubmed Publications
Uncharacterized Tissue Antibodies	>1 publications with UBE2R2 and Uncharacterized Tissue