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Interleukin-17 Receptor A (IL17RA) Human Active Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS2556693

Protein Construction: Recombinant Human Interleukin-17 receptor A is produced by our Mammalian expression system and the target gene encoding Leu33-Trp320 is expressed with a Fc tag at the C-terminus.Background: Interleukin 17A (IL17A) is a proinflammatory… More details

$150 / 0.01 mg +1 FREE 8GB USB
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
Interleukin-17 Receptor A (IL17RA), Active Protein
Full Product Name
Recombinant Human Interleukin-17 Receptor A Protein
Product Gene Name
Product Synonym Names
Interleukin-17 receptor A; IL-17 receptor A; IL-17RA; CDw217; CD_antigen; CD217; IL17RA; IL17R
Host
Human Cells
Form/Format
Lyophilized from a 0.2 mum filtered solution of PBS, pH 7.4.
Purity/Purification
>90% as determined by reducing SDS-PAGE.
Preparation and Storage
Lyophilized protein should be stored at < -20 degree C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7 degree C for 2-7 days.
Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.
Molecular Weight
Molecular Mass: 60.6kDa
Actual Protein Molecular Mass: 90-120kDa
3D Structure
ModBase 3D Structure for Q96F46
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Species
Human
Endotoxin
<1.0 EU per ug as determined by LAL test.
Fragment
Leu33-Trp320
Fusion Tag
C-Fc
Activity
Measured by its binding ability in a functional ELISA. Immobilized recombinant human IL17A at 2 mug/ml (100 mul/well) can bind biotinylated human IL17RA with a linear range of 1.28-32 ng/ml. 2. Measured by its ability to inhibit IL-17-induced IL-6 secretion by HFF human foreskin fibroblast cells. The ED50 for this effect is typically 0.03-0.12 mug/mL.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of IL17RA active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IL17RA purchase

MBS2556693 is an active protein targeting IL17RA. Also known as Recombinant Human Interleukin-17 Receptor A Protein. Host: Human Cells.

Additional Details

NCBI/Uniprot data below describe general gene information for IL17RA. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
interleukin-17 receptor A isoform 1
NCBI Official Synonym Full Names
interleukin 17 receptor A
NCBI Official Symbol
IL17RA
NCBI Official Synonym Symbols
CD217; IL17R; IMD51; CANDF5; CDw217; IL-17RA; hIL-17R
UniProt Protein Name
Interleukin-17 receptor A
UniProt Synonym Protein Names
CDw217; CD_antigen: CD217
UniProt Gene Name
IL17RA
UniProt Synonym Gene Names
IL17R; IL-17 receptor A; IL-17RA
NCBI Protein Information
interleukin-17 receptor A

NCBI Summary for IL17RA

Interleukin 17A (IL17A) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. The transmembrane protein encoded by this gene (interleukin 17A receptor; IL17RA) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors, this receptor likely has a multimeric structure. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2014]
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UniProt Comments for IL17RA

Receptor for IL17A (PubMed:17911633, PubMed:9367539). Receptor for IL17F (PubMed:19838198, PubMed:17911633). Binds to IL17A with higher affinity than to IL17F (PubMed:17911633). Binds IL17A and IL17F homodimers as part of a heterodimeric complex with IL17RC (PubMed:16785495). Also binds heterodimers formed by IL17A and IL17F as part of a heterodimeric complex with IL17RC (PubMed:18684971). Receptor for IL17C as part of a heterodimeric complex with IL17RE (PubMed:21993848). Activation of IL17RA leads to induction of expression of inflammatory chemokines and cytokines such as CXCL1, CXCL8/IL8 and IL6 (PubMed:16785495, PubMed:17911633, PubMed:18684971).
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with IL17RA active protein

 Reference Product  PubMed Publications
 IL17A active protein  >87 publications with IL17RA and IL17A
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