Neuritin (NRN) Active Protein

Name: NRN Active Protein; Neuritin; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS845330
Price: 295 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS845330

Background: Neuritin is a neurotrophic factor, which is expressed in response to induction of neuronal activity by NGF, BDNF, NT3, and other neural stimulators. It is expressed primarily in post mitotic-differentiating neurons of the developing nervous system… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

Neuritin (NRN), Active Protein

Full Product Name

Neuritin, human recombinant

Product Gene Name

NRN active protein

Product Synonym Names

CPG15; NRN1

Sequence

AGKCDAVFKG FSDCLLKLGD SMANYPQGLD DKTNIKTVCT YWEDFHSCTV TALTDCQEGA KDMWDKLRKE SKNLNIQGSL FELCGSGN

Host

E Coli

Form/Format

Sterile filtered through a 0.2 micron filter. Lyophilized with no additives
Appearance: Lyophilized powder

Purity/Purification

>=98%

Preparation and Storage

At -20 degree C
Shelf Life: 12 months

Molecular Weight

9.72 kDa

OMIM

607409

3D Structure

ModBase 3D Structure for Q9NPD7

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Solubility/Reconstitution Instructions

Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8 degree C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20 degree C to -80 degree C.

Endotoxin Level

< 0.1 ng/mug of protein (<1EU/mug).

Activity (Specifications/test method)

Determined by a cell proliferation using rat C6 cells. The ED50 for this effect is 20.0-30.0 ng/ml.

Biological Activity

Determined by a cell proliferation using rat C6 cells. The ED50 for this effect is 20.0-30.0 ng/ml.

Handling

Centrifuge the vial prior to opening.

Product Categories/Family for NRN active protein

Cytokines; Growth Factors & Hormones; Cytokines & Growth Factors (A-Z) Proteins and Enzymes; Cytokines; Growth Factors & Hormones; Cytokines & Growth Factors (A-Z) Proteins and Enzymes; Animal-Free Origin (AOF) Recombinant Proteins & EnzymesProteins and E

Applications Tested/Suitable for NRN active protein

SDS-PAGE; HPLC

Other Notes

Small volumes of NRN active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for NRN purchase

MBS845330 is an active protein targeting NRN. Also known as Neuritin, human recombinant. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for NRN. It may not necessarily be applicable to this product.

NCBI GI #

525314165

NCBI GeneID

51299

NCBI Accession #

NP_001265639.1

UniProt Primary Accession #

Q9NPD7

UniProt Secondary Accession #

Q7Z4Y1; B2RA93

UniProt Related Accession #

Q9NPD7

GenBank Nucleotide #

NM_001278710.1

NCBI Official Full Name

neuritin isoform 1

NCBI Official Synonym Full Names

neuritin 1

NCBI Official Symbol

NRN1

NCBI Official Synonym Symbols

NRN; dJ380B8.2

UniProt Protein Name

Neuritin

Protein Family

Neuritin

UniProt Gene Name

NRN1

UniProt Synonym Gene Names

NRN

UniProt Entry Name

NRN1_HUMAN

NCBI Protein Information

neuritin

NCBI Summary for NRN

This gene encodes a member of the neuritin family, and is expressed in postmitotic-differentiating neurons of the developmental nervous system and neuronal structures associated with plasticity in the adult. The expression of this gene can be induced by neural activity and neurotrophins. The encoded protein contains a consensus cleavage signal found in glycosylphoshatidylinositol (GPI)-anchored proteins. The encoded protein promotes neurite outgrowth and arborization, suggesting its role in promoting neuritogenesis. Overexpression of the encoded protein may be associated with astrocytoma progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

UniProt Comments for NRN

NRN1: Promotes neurite outgrowth and especially branching of neuritic processes in primary hippocampal and cortical cells. Belongs to the neuritin family.

Protein type: Membrane protein, GPI anchor

Chromosomal Location of Human Ortholog: 6p25.1

Cellular Component: plasma membrane; synapse; cell junction

Biological Process: nervous system development

Research Articles on NRN

1. Neuritin is reduced in the brains of Alzheimer's disease (AD) patients.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with NRN active protein

Reference Product	PubMed Publications
NTF3 active protein	>1 publications with NRN and NTF3
ELAVL4 active protein	>1 publications with NRN and ELAVL4

Diseases associated with NRN active protein

Disease Name	Pubmed Publications
Brain Diseases Antibodies	>12 publications with NRN and Brain Diseases
Vascular Diseases Antibodies	>4 publications with NRN and Vascular Diseases
Metaplasia Antibodies	>3 publications with NRN and Metaplasia
Breast Neoplasms Antibodies	>2 publications with NRN and Breast Neoplasms
Neurobehavioral Manifestations Antibodies	>2 publications with NRN and Neurobehavioral Manifestations
Depressive Disorder Antibodies	>2 publications with NRN and Depressive Disorder
Atrophy Antibodies	>2 publications with NRN and Atrophy
Diabetes Mellitus Antibodies	>1 publications with NRN and Diabetes Mellitus
Learning Disorders Antibodies	>1 publications with NRN and Learning Disorders
Hypertension Antibodies	>1 publications with NRN and Hypertension

Organs/Tissues associated with NRN active protein

Organ/Tissue Name	Pubmed Publications
Nerve Antibodies	>24 publications with NRN and Nerve
Brain Antibodies	>24 publications with NRN and Brain
Eye Antibodies	>10 publications with NRN and Eye
Blood Antibodies	>4 publications with NRN and Blood
Embryonic Tissue Antibodies	>3 publications with NRN and Embryonic Tissue
Muscle Antibodies	>2 publications with NRN and Muscle
Liver Antibodies	>1 publications with NRN and Liver
Spleen Antibodies	>1 publications with NRN and Spleen
Lung Antibodies	>1 publications with NRN and Lung
Heart Antibodies	>1 publications with NRN and Heart