IGF-BP2 (IGFBP2) Active Protein

Name: IGFBP2 Active Protein; IGF-BP2; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS845343
Price: 315 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS845343

Background: IGF-BPs controls the distribution, function and activity of IGFs in various cell tissues and body fluids. Currently there are seven named IGF-BPs that form high affinity complexes with both IGF-I and IGF-II. IGF-BP2 is a cysteine-rich secreted… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

IGF-BP2 (IGFBP2), Active Protein

Full Product Name

IGF-BP2, human recombinant

Product Gene Name

IGFBP2 active protein

Product Synonym Names

IBP-2

Sequence

EVLFRCPPCT PERLAACGPP PVAPPAAVAA VAGGARMPCA ELVREPGCGC CSVCARLEGE ACQVYTPRCG QGLRCYPHPG SELPLQALVM GEGTCEKRRD AEYGASPEQV ADNGDDHSEG GLVENHVDST MNMLGGGGSA GRKPLKSGMK ELAVFREKVT EQHRQMGKGG KHHLGLEEPK KLRPPPARTP CQQELDQVLE RISTMRLPDE RGPLEHLYSL HIPNCDKHGL YNLKQCKMSL NGQRGECWCV NPNTGKLIQG APTIRGDPEC HLFYNEQQEA RGVHTQRMQ

Host

(BTI-Tn-5B1-4) Hi-5 Insect cells

Form/Format

Sterile filtered through a 0.2 micron filter. Lyophilized from 1 x PBS, pH 7.2.
Appearance: Lyophilized powder

Purity/Purification

>=98%

Preparation and Storage

At -20 degree C
Shelf Life: 12 months

Molecular Weight

31.5 kDa

OMIM

146731

3D Structure

ModBase 3D Structure for P18065

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Solubility/Reconstitution Instructions

Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8 degree C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20 degree C to -80 degree C.

Endotoxin Level

< 0.1 ng/mug of protein (<1EU/mug).

Activity (Specifications/test method)

Determined by its ability to inhibit IGF-I induced proliferation of FDC-P1 cells.

Biological Activity

Determined by its ability to inhibit IGF-I induced proliferation of FDC-P1 cells.

Handling

Centrifuge the vial prior to opening.

Product Categories/Family for IGFBP2 active protein

Cytokines; Growth Factors & Hormones; IGFsCytokines; Growth Factors & Hormones; Cytokines & Growth Factors (A-Z) Proteins and Enzymes; Cytokines; Growth Factors & Hormones; IGFsProteins and Enzymes; Cytokines; Growth Factors & Hormones; Cytokines & Growth

Applications Tested/Suitable for IGFBP2 active protein

SDS-PAGE; HPLC

Other Notes

Small volumes of IGFBP2 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IGFBP2 purchase

MBS845343 is an active protein targeting IGFBP2. Also known as IGF-BP2, human recombinant. Host: (BTI-Tn-5B1-4) Hi-5 Insect cells.

Additional Details

NCBI/Uniprot data below describe general gene information for IGFBP2. It may not necessarily be applicable to this product.

NCBI GI #

55925576

NCBI GeneID

3485

NCBI Accession #

NP_000588.2

UniProt Primary Accession #

P18065

UniProt Secondary Accession #

Q14619; Q9UCL3

UniProt Related Accession #

P18065

GenBank Nucleotide #

NM_000597.2

NCBI Official Full Name

insulin-like growth factor-binding protein 2

NCBI Official Synonym Full Names

insulin-like growth factor binding protein 2, 36kDa

NCBI Official Symbol

IGFBP2

NCBI Official Synonym Symbols

IBP2; IGF-BP53

UniProt Protein Name

Insulin-like growth factor-binding protein 2

Protein Family

Insulin-like growth factor-binding protein

UniProt Gene Name

IGFBP2

UniProt Synonym Gene Names

BP2; IBP2; IBP-2; IGF-binding protein 2; IGFBP-2

UniProt Entry Name

IBP2_HUMAN

NCBI Protein Information

insulin-like growth factor-binding protein 2

UniProt Comments for IGFBP2

IGFBP2: Inhibits IGF-mediated growth and developmental rates. IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Binds IGF2 more than IGF1.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 2q35

Cellular Component: extracellular space; apical plasma membrane; extracellular region; cytoplasmic vesicle

Molecular Function: protein binding; insulin-like growth factor I binding; insulin-like growth factor II binding

Biological Process: response to drug; regulation of insulin-like growth factor receptor signaling pathway; response to retinoic acid; response to lithium ion; response to glucocorticoid stimulus; female pregnancy; positive regulation of activated T cell proliferation; signal transduction; response to estradiol stimulus; cellular response to hormone stimulus; cellular protein metabolic process; response to mechanical stimulus; regulation of cell growth; response to nutrient; aging

Research Articles on IGFBP2

1. higher baseline IGF-II and IGFBP-2 predict increased HDL concentration over time, implicating IGF-II in modulation of circulating HDL-cholesterol concentrations.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with IGFBP2 active protein

Reference Product	PubMed Publications
IGF1 active protein	>67 publications with IGFBP2 and IGF1
IGF2 active protein	>59 publications with IGFBP2 and IGF2
PTEN active protein	>22 publications with IGFBP2 and PTEN
FGF2 active protein	>11 publications with IGFBP2 and FGF2
IL6 active protein	>5 publications with IGFBP2 and IL6
INS active protein	>5 publications with IGFBP2 and INS
LEP active protein	>2 publications with IGFBP2 and LEP
MIIP active protein	>1 publications with IGFBP2 and MIIP

Pathways associated with IGFBP2 active protein

Products by Pathway	Pathway Diagram
Metabolism Of Proteins Pathway antibodies	Metabolism Of Proteins Pathway Diagram
Myometrial Relaxation And Contraction Pathways antibodies	Myometrial Relaxation And Contraction Pathways Diagram
Regulation Of Insulin-like Growth Factor (IGF) Transport And Uptake By Insulin-like Growth Factor Binding Proteins (IGFBPs) Pathway antibodies	Regulation Of Insulin-like Growth Factor (IGF) Transport And Uptake By Insulin-like Growth Factor Binding Proteins (IGFBPs) Pathway Diagram

Diseases associated with IGFBP2 active protein

Disease Name	Pubmed Publications
Brain Diseases Antibodies	>89 publications with IGFBP2 and Brain Diseases
Insulin Resistance Antibodies	>69 publications with IGFBP2 and Insulin Resistance
Breast Neoplasms Antibodies	>59 publications with IGFBP2 and Breast Neoplasms
Obesity Antibodies	>57 publications with IGFBP2 and Obesity
Adenocarcinoma Antibodies	>55 publications with IGFBP2 and Adenocarcinoma
Kidney Diseases Antibodies	>49 publications with IGFBP2 and Kidney Diseases
Cardiovascular Diseases Antibodies	>48 publications with IGFBP2 and Cardiovascular Diseases
Liver Diseases Antibodies	>40 publications with IGFBP2 and Liver Diseases
Weight Gain Antibodies	>35 publications with IGFBP2 and Weight Gain
Neoplasms, Experimental Antibodies	>35 publications with IGFBP2 and Neoplasms, Experimental

Organs/Tissues associated with IGFBP2 active protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>647 publications with IGFBP2 and Blood
Liver Antibodies	>193 publications with IGFBP2 and Liver
Brain Antibodies	>160 publications with IGFBP2 and Brain
Ovary Antibodies	>125 publications with IGFBP2 and Ovary
Bone Antibodies	>123 publications with IGFBP2 and Bone
Muscle Antibodies	>119 publications with IGFBP2 and Muscle
Kidney Antibodies	>104 publications with IGFBP2 and Kidney
Prostate Antibodies	>79 publications with IGFBP2 and Prostate
Lung Antibodies	>74 publications with IGFBP2 and Lung
Embryonic Tissue Antibodies	>67 publications with IGFBP2 and Embryonic Tissue