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Pd-1/PDCD1, C-Fc Tag (PDCD1) Active Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS845363

Background: Programmed cell death protein 1 (PD-1) is also known as CD279 and PDCD1, is a type I membrane protein and is a member of the extended CD28/CTLA-4 family of T cell regulators. PDCD1 is expressed on the surface of activated T cells, B cells,… More details

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Testing Data View PDF
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Product Overview

Product Name
PD-1/PDCD1, C-Fc Tag, Active Protein
Full Product Name
Human CellExp PD-1 / PDCD1, C-Fc Tag, mouse recombinant
Product Gene Name
PDCD1 active protein
Product Synonym Names
PD; PD 1; PD 1 protein; PD 1 recombinant protein; mouse PD 1 protein; mouse recombinant PD 1 protein; mouse recombinant PD 1; mouse PD 1; recombinant PD 1; Human cell expressed PD 1; Human cell expressed PD 1 protein; Human cell expressed recombinant PD 1; Human cell expressed recombinant PD 1 protein; PD; PD-1; PD-1 protein; PD-1 recombinant protein; mouse PD-1 protein; mouse recombinant PD-1 protein; mouse recombinant PD-1; mouse PD-1; recombinant PD-1; Human cell expressed PD-1; Human cell expressed PD-1 protein; Human cell expressed recombinant PD-1; Human cell expressed recombinant PD-1 protein; PD; PD1; PD1 protein; PD1 recombinant protein; mouse PD1 protein; mouse recombinant PD1 protein; mouse recombinant PD1; mouse PD1; recombinant PD1; Human cell expressed PD1; Human cell expressed PD1 protein; Human cell expressed recombinant PD1; Human cell expressed recombinant PD1 protein; PD1; PDCD1; PD1; CD279; SLEB2; hPD-1; hPD-l; October-RP-14; PDCD; PDCD 1; PDCD 1 protein; PDCD 1 recombinant protein; mouse PDCD 1 protein; mouse recombinant PDCD 1 protein; mouse recombinant PDCD 1; mouse PDCD 1; recombinant PDCD 1; Human cell expressed PDCD 1; Human cell expressed PDCD 1 protein; Human cell expressed recombinant PDCD 1; Human cell expressed recombinant PDCD 1 protein; PDCD; PDCD-1; PDCD-1 protein; PDCD-1 recombinant protein; mouse PDCD-1 protein; mouse recombinant PDCD-1 protein; mouse recombinant PDCD-1; mouse PDCD-1; recombinant PDCD-1; Human cell expressed PDCD-1; Human cell expressed PDCD-1 protein; Human cell expressed recombinant PDCD-1; Human cell expressed recombinant PDCD-1 protein; PDCD; PDCD1; PDCD1 protein; PDCD1 recombinant protein; mouse PDCD1 protein; mouse recombinant PDCD1 protein; mouse recombinant PDCD1; mouse PDCD1; recombinant PDCD1; Human cell expressed PDCD1; Human cell expressed PDCD1 protein; Human cell expressed recombinant PDCD1; Human cell expressed recombinant PDCD1 protein; PDCD1
Host
HEK293 cells
Form/Format
Lyophilized from 0.22 mum filtered solution in 50 mM Tris, 100 mM glycine, pH 7.5. Normally Mannitol or Trehalose is added as protectants before lyophilization.
Appearance: Lyophilized
Purity/Purification
>=92%
Preparation and Storage
At -20 degree C
Shelf Life: 12 months
Molecular Weight
This protein is fused with a human IgG1 Fc tag at the C-terminus, and has a calculated MW of 43.2 kDa. The predicted N-terminus is Ser 21. DTT-reduced Protein migrates as 60-66 kDa in SDS-PAGE due to glycosylation.
3D Structure
ModBase 3D Structure for Q02242
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Solubility/Reconstitution Instructions
Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 ug/ml. Do not vortex. This solution can be stored at 2-8 degree C for up to 1 month. For extended storage, it is recommended to store at -20 degree C.
Endotoxin Level
<1 EU/mug by LAL method
Biological Activity
Measured by its binding ability in a functional ELISA. Immobilized recombinant mouse PD-1 /PDCD1 Fc Chimera at 2 ug/mL (100 ul/well) can bind biotinylated Mouse PD-L1 with a linear range of 32 - 500 ng/mL.
Results
Measured by its binding ability in a functional ELISA. Immobilized recombinant mouse PD-1 /PDCD1 Fc Chimera at 2 ug/mL (100 ul/well) can bind biotinylated Mouse PD-L1 with a linear range of 32 - 500 ng/mL.
Handling
Centrifuge the vial prior to opening.

Product Categories/Family for PDCD1 active protein

Cytokines; Growth Factors & Hormones; Human cell expressed recombinant proteins Proteins and Enzymes; Human cell expressed recombinant proteins Cytokines; Growth Factors & Hormones; CDsProteins and Enzymes; Cytokines; Growth Factors & Hormones; CDsCytokin
Applications Tested/Suitable for PDCD1 active protein
SDS-PAGE

Testing Data of PDCD1 active protein

PDCD1 Active Protein – Cat# MBS845363

Other Notes

Small volumes of PDCD1 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PDCD1 purchase

MBS845363 is an active protein targeting PDCD1. Also known as Human CellExp PD-1 / PDCD1, C-Fc Tag, mouse recombinant. Host: HEK293 cells.

Additional Details

NCBI/Uniprot data below describe general gene information for PDCD1. It may not necessarily be applicable to this product.

NCBI GI #
6679239
NCBI GeneID
18566
NCBI Accession #
NP_032824.1
UniProt Primary Accession #
Q02242
UniProt Related Accession #
Q02242
GenBank Nucleotide #
NM_008798.2
NCBI Official Full Name
programmed cell death protein 1
NCBI Official Synonym Full Names
programmed cell death 1
NCBI Official Symbol
Pdcd1
NCBI Official Synonym Symbols
PD-1; Pdc1; Ly101
UniProt Protein Name
Programmed cell death protein 1
UniProt Synonym Protein Names
CD_antigen: CD279
Protein Family
Programmed cell death protein
UniProt Gene Name
Pdcd1
UniProt Synonym Gene Names
Pd1; Protein PD-1; mPD-1
UniProt Entry Name
PDCD1_MOUSE
NCBI Protein Information
programmed cell death protein 1

UniProt Comments for PDCD1

PDCD1: a single-pass type I membrane protein. A negative regulator of activated T cells, is upregulated in human and mouse 'exhausted' T cells during persistent viral infection. A marker of angioimmunoblastic T-cell lymphoma and germinal center associated T cells.

Protein type: Apoptosis; Membrane protein, integral

Cellular Component: membrane; plasma membrane; integral to membrane; external side of plasma membrane

Molecular Function: protein binding

Biological Process: positive regulation of apoptosis; apoptosis; immune system process; negative regulation of tolerance induction; negative regulation of apoptosis
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Research Articles on PDCD1

1. These findings reflect the fact that primary keratinocytes express PD-L1 when stimulated by interferon-gamma in vitro

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with PDCD1 active protein

 Reference Product  PubMed Publications
 Cd4 active protein  >449 publications with PDCD1 and Cd4
 Cd274 active protein  >364 publications with PDCD1 and Cd274
 Pdcd1lg2 active protein  >102 publications with PDCD1 and Pdcd1lg2
 Ptpn6 active protein  >7 publications with PDCD1 and Ptpn6
 Ptpn11 active protein  >5 publications with PDCD1 and Ptpn11
 Lck active protein  >3 publications with PDCD1 and Lck
 Cd3e active protein  >1 publications with PDCD1 and Cd3e
 Cd247 active protein  >1 publications with PDCD1 and Cd247

Pathways associated with PDCD1 active protein

 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Costimulation By The CD28 Family Pathway antibodies  Costimulation By The CD28 Family Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 PD-1 Signaling Pathway antibodies  PD-1 Signaling Pathway Diagram
 T Cell Receptor Signaling Pathway antibodies  T Cell Receptor Signaling Pathway Diagram
 T Cell Receptor Signaling Pathway antibodies  T Cell Receptor Signaling Pathway Diagram

Diseases associated with PDCD1 active protein

 Disease Name  Pubmed Publications
 Death Antibodies  >1282 publications with PDCD1 and Death
 Liver Diseases Antibodies  >154 publications with PDCD1 and Liver Diseases
 Inflammation Antibodies  >128 publications with PDCD1 and Inflammation
 Melanoma Antibodies  >95 publications with PDCD1 and Melanoma
 Necrosis Antibodies  >83 publications with PDCD1 and Necrosis
 Lupus Erythematosus, Systemic Antibodies  >77 publications with PDCD1 and Lupus Erythematosus, Systemic
 Lung Diseases Antibodies  >72 publications with PDCD1 and Lung Diseases
 Adenocarcinoma Antibodies  >42 publications with PDCD1 and Adenocarcinoma
 Kidney Diseases Antibodies  >32 publications with PDCD1 and Kidney Diseases
 Liver Neoplasms Antibodies  >26 publications with PDCD1 and Liver Neoplasms

Organs/Tissues associated with PDCD1 active protein

 Organ/Tissue Name  Pubmed Publications
 Thymus Antibodies  >23 publications with PDCD1 and Thymus
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