Il-1 Alpha (IL1A) Active Protein

Name: IL1A Active Protein; Il-1 Alpha; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS845365
Price: 315 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS845365

Background: Interleukin-1 alpha (IL-1alpha is a potent immuno-modulator that mediates a wide range of immune and inflammatory responses. Rat IL-1alpha is a 17.7 kDa protein containing 155 amino acid residues. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

IL-1 alpha (IL1A), Active Protein

Full Product Name

IL-1 alpha, rat recombinant

Product Gene Name

IL1A active protein

Product Synonym Names

Hematopoietin-1; Lymphocyte-activating factor (LAF); Endogenous Pyrogen (EP); Leukocyte Endogenous Mediator (LEM); Mononuclear Cell Factor (MCF)

Host

E Coli

Form/Format

Sterile filtered and lyophilized from 1 mM Tris buffer, pH 8.0
Appearance: Lyophilized protein

Purity/Purification

>=98%

Preparation and Storage

At -20 degree C
Shelf Life: 12 months

Molecular Weight

17.7 kDa

3D Structure

ModBase 3D Structure for P16598

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Solubility/Reconstitution Instructions

Reconstitute in H?O to a concentration of 0.1-1.0 mg/ml. The solution can then be diluted into other aqueous buffers and stored at 4 degree C for 1 week or -20 degree C for future use.

Endotoxin Level

<0.1 ng/mug

Biological Activity

The ED?? as determined by the dose-dependent stimulation of the proliferation of murine D10S cells is <0.005 ng/ml, corresponding to a specific activity of >2 x 10? units/mg.

Results

<0.005 ng/ml

Handling

Centrifuge the vial prior to opening.

Applications Tested/Suitable for IL1A active protein

SDS-PAGE; HPLC

Other Notes

Small volumes of IL1A active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IL1A purchase

MBS845365 is an active protein targeting IL1A. Also known as IL-1 alpha, rat recombinant. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for IL1A. It may not necessarily be applicable to this product.

NCBI GI #

8393593

NCBI GeneID

24493

NCBI Accession #

NP_058715.1

UniProt Primary Accession #

P16598

UniProt Secondary Accession #

Q546R9

UniProt Related Accession #

P16598

GenBank Nucleotide #

NM_017019.1

NCBI Official Full Name

interleukin-1 alpha

NCBI Official Synonym Full Names

interleukin 1 alpha

NCBI Official Symbol

Il1a

NCBI Official Synonym Symbols

IL-1 alpha

UniProt Protein Name

Interleukin-1 alpha

Protein Family

Interleukin

UniProt Gene Name

Il1a

UniProt Synonym Gene Names

IL-1 alpha

UniProt Entry Name

IL1A_RAT

NCBI Protein Information

interleukin-1 alpha

NCBI Summary for IL1A

proinflammatory cytokine [RGD, Feb 2006]

UniProt Comments for IL1A

Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.

Research Articles on IL1A

1. There is increased expression of Il-1alpha in the spinal cord 1 day after painful facet joint injury.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with IL1A active protein

Reference Product	PubMed Publications
Il1b active protein	>209 publications with IL1A and Il1b
Il6 active protein	>105 publications with IL1A and Il6
Il1rn active protein	>100 publications with IL1A and Il1rn
Tgfb1 active protein	>17 publications with IL1A and Tgfb1
Il1r1 active protein	>16 publications with IL1A and Il1r1
Icam1 active protein	>13 publications with IL1A and Icam1
Csf2 active protein	>11 publications with IL1A and Csf2
Il1r2 active protein	>3 publications with IL1A and Il1r2
Il1rl2 active protein	>1 publications with IL1A and Il1rl2

Pathways associated with IL1A active protein

Products by Pathway	Pathway Diagram
Apoptosis Pathway antibodies	Apoptosis Pathway Diagram
Apoptosis Pathway antibodies	Apoptosis Pathway Diagram
Cytokine Signaling In Immune System Pathway antibodies	Cytokine Signaling In Immune System Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokines And Inflammatory Response (BioCarta) Pathway antibodies	Cytokines And Inflammatory Response (BioCarta) Pathway Diagram
FAS Pathway And Stress Induction Of HSP Regulation antibodies	FAS Pathway And Stress Induction Of HSP Regulation Diagram
Graft-versus-host Disease Pathway antibodies	Graft-versus-host Disease Pathway Diagram
Graft-versus-host Disease Pathway antibodies	Graft-versus-host Disease Pathway Diagram
Hematopoietic Cell Lineage Pathway antibodies	Hematopoietic Cell Lineage Pathway Diagram

Diseases associated with IL1A active protein

Disease Name	Pubmed Publications
Inflammation Antibodies	>99 publications with IL1A and Inflammation
Necrosis Antibodies	>63 publications with IL1A and Necrosis
Skin Diseases Antibodies	>34 publications with IL1A and Skin Diseases
Lung Neoplasms Antibodies	>9 publications with IL1A and Lung Neoplasms
Pain Antibodies	>9 publications with IL1A and Pain
Fibrosis Antibodies	>9 publications with IL1A and Fibrosis
Heart Diseases Antibodies	>9 publications with IL1A and Heart Diseases
Kidney Diseases Antibodies	>8 publications with IL1A and Kidney Diseases
Liver Diseases Antibodies	>7 publications with IL1A and Liver Diseases
Hypertension Antibodies	>6 publications with IL1A and Hypertension

Organs/Tissues associated with IL1A active protein

Organ/Tissue Name	Pubmed Publications
Prostate Antibodies	>5 publications with IL1A and Prostate