Human BD 2 Active Protein – Cat# MBS143289

Beta Defensin -2 (BD 2) Human Active Protein

Name: BD 2 Active Protein; Beta Defensin -2; Human; MyBioSource
Brand: MyBioSource
SKU: MBS143289
Price: 250 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS143289

Description: Beta Defensin-2 Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 41 amino acids and having a molecular mass of 4.3 kDa. The BD-2 is purified by proprietary chromatographic techniques.Introduction:… More details

$250 / 0.005 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Beta Defensin -2 (BD 2), Active Protein

Full Product Name

Recombinant Human Beta Defensin -2

Product Gene Name

BD 2 active protein

Product Synonym Names

BD 2 Human; Beta Defensin-2 Human Recombinant; BD-2; hBD-2; Defensin beta 2; Skin-antimicrobial peptide 1; SAP1; DEFB4; DEFB102; DEFB2; DEFB4P; Beta-defensin 2

Sequence

GIGDPVTCLK SGAICHPVFC PRRYKQIGTC GLPGTKCCKK P

Host

E Coli

Form/Format

The Human BD-2 was lyophilized from a 0.2 um filtered concentrated (1mg/ml) solution containing 20mM PB pH-7.4 and 130mM NaCl.
Sterile Filtered White lyophilized (freeze-dried) powder.

Purity/Purification

Greater than 98.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.

Preparation and Storage

Lyophilized Beta Defensin-2 Recombinant although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution BD-2 should be stored at 4 degree C between 2-7 days and for future use below -18 degree C.Please prevent freeze-thaw cycles.

Molecular Weight

7,038 Da

OMIM

602215

3D Structure

ModBase 3D Structure for O15263

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Solubility

It is recommended to reconstitute the lyophilized Beta Defensin-2 in sterile 18M Omega -cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.

Biological Activity

Determined by the ability to chemoattract human dendritic immature cells at a concentration of 10-100ng/ml.

Product Categories/Family for BD 2 active protein

Cytokines and Growth Factors; Cytokines; Beta Defensin

Other Notes

Small volumes of BD 2 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for BD 2 purchase

MBS143289 is an active protein targeting BD 2. Also known as Recombinant Human Beta Defensin -2. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for BD 2. It may not necessarily be applicable to this product.

NCBI GI #

327532771

NCBI GeneID

100289462

NCBI Accession #

NP_001192195.1

UniProt Primary Accession #

O15263

UniProt Secondary Accession #

Q52LC0

GenBank Nucleotide #

NM_001205266.1

NCBI Official Full Name

beta-defensin 4B

NCBI Official Synonym Full Names

defensin, beta 4B

NCBI Official Symbol

DEFB4B

NCBI Official Synonym Symbols

DEFB4P

UniProt Protein Name

Beta-defensin 4A

UniProt Synonym Protein Names

Beta-defensin 2; BD-2; hBD-2; Defensin, beta 2; Skin-antimicrobial peptide 1; SAP1

Protein Family

Beta-defensin

UniProt Gene Name

DEFB4A

UniProt Synonym Gene Names

DEFB102; DEFB2; DEFB4; BD-2; hBD-2; SAP1

UniProt Entry Name

DFB4A_HUMAN

NCBI Protein Information

beta-defensin 4B; beta defensin 2; beta defensin-2; beta-defensin 2; defensin, beta 4, pseudogene

NCBI Summary for BD 2

Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils. Members of the defensin family are highly similar in protein sequence. This gene encodes defensin, beta 4, an antibiotic peptide which is locally regulated by inflammation. [provided by RefSeq, Oct 2014]

UniProt Comments for BD 2

defensin, beta 2: Has antibacterial activity (Potential). Belongs to the beta-defensin family. LAP/TAP subfamily.

Protein type: Secreted; Motility/polarity/chemotaxis; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 8p23.1

Cellular Component: Golgi lumen; extracellular region

Biological Process: G-protein coupled receptor protein signaling pathway; defense response to bacterium; innate immune response; immune response; chemotaxis

Research Articles on BD 2

1. The encoded peptide has antimicrobial activity against E.coli, S. aureus, and P. aeruginosa.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with BD 2 active protein

Products by Pathway	Pathway Diagram
Beta Defensins Pathway antibodies	Beta Defensins Pathway Diagram
Defensins Pathway antibodies	Defensins Pathway Diagram
Immune System Pathway antibodies	Immune System Pathway Diagram
Innate Immune System Pathway antibodies	Innate Immune System Pathway Diagram