Caspase 1 (CASP1) Antibody – Rabbit Polyclonal

CASP1: Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 20 kDa (p20) and a 10 kDa (p10) subunit. The p20 subunit can also form a heterodimer with the epsilon isoform which then has an inhibitory effect. May be a component of the inflammasome, a protein complex which also includes PYCARD, CARD8 and NALP2 and whose function would be the activation of proinflammatory caspases. Interacts with CARD17/INCA and CARD18. Expressed in larger amounts in spleen and lung. Detected in liver, heart, small intestine, colon, thymus, prostate, skeletal muscle, peripheral blood leukocytes, kidney and testis. No expression in the brain. Specifically inhibited by the cowpox virus Crma protein. Belongs to the peptidase C14A family. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Apoptosis; EC 3.4.22.36; Protease

Chromosomal Location of Human Ortholog: 9 A1|9 2.46 cM

Cellular Component: cytoplasm; extracellular region; neuron projection; nucleus; protein complex

Molecular Function: cysteine-type endopeptidase activity; endopeptidase activity; identical protein binding; kinase binding; peptidase activity; protein binding

Biological Process: interleukin-1 beta production; membrane hyperpolarization; memory; microglial cell activation; mitochondrial depolarization; myoblast fusion; positive regulation of apoptosis; positive regulation of circadian sleep/wake cycle, non-REM sleep; positive regulation of cytokine secretion; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of interleukin-1 alpha secretion; positive regulation of interleukin-1 beta secretion; protein processing; proteolysis; regulation of autophagy; regulation of inflammatory response; response to ATP; response to bacterium; response to drug; response to hypoxia; response to lipopolysaccharide; response to organic cyclic substance