Rabbit Anti-SERPINA1 Polyclonal Antibody – Cat# MBS845537

Alpha1 Antitrypsin (SERPINA1) Antibody – Rabbit Polyclonal

Name: SERPINA1 Antibody; Polyclonal; Rabbit; Human/Mouse/Rat-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS845537
Price: 215 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS845537

Polyclonal Antibody to detect Alpha1 Antitrypsin in Human; Mouse; Rat samples.Alpha 1 Antitrypsin is an acute-phase plasma protein found at 290 mg per 100 ml. It functions as a serine protease inhibitor with targets like elastase; plasmin; collagenase;… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

Alpha1 Antitrypsin (SERPINA1), Polyclonal Antibody

Full Product Name

Alpha1 Antitrypsin Antibody

Product Gene Name

anti-SERPINA1 antibody

Product Synonym Names

Alpha-1 protease inhibitor; Alpha-1-antiproteinase; Serpin A1; AAT; PI

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Form/Format

Colorless liquid
30 ug (0.5 mg/ml) of antibody in PBS pH 7.2; 0.01 % BSA; 0.03 % ProClin; and 50 % glycerol.

Purity/Purification

Affinity Purified

Concentration

0.5 mg/ml (lot specific)

Preparation and Storage

Store at -20 degree C for 12 months.
The antibody solution should be gently mixed before use.

Molecular Weight

34,755 Da

OMIM

K01396 mRNA

3D Structure

ModBase 3D Structure for P01009

Immunogen

Human alpha1 antitrypsin

Product Categories/Family for anti-SERPINA1 antibody

Alpha1 Antitrypsin

Applications Tested/Suitable for anti-SERPINA1 antibody

Western Blot (WB)

Application Notes for anti-SERPINA1 antibody

Western Blot: 1-4 ug

Other Notes

Small volumes of anti-SERPINA1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SERPINA1 purchase

MBS845537 is an antibody targeting SERPINA1. Also known as Alpha1 Antitrypsin Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for SERPINA1. It may not necessarily be applicable to this product.

NCBI GI #

50363217

NCBI GeneID

5265

NCBI Accession #

NP_000286.3

UniProt Primary Accession #

P01009

UniProt Secondary Accession #

Q0PVP5; Q13672; Q53XB8; Q5U0M1; Q7M4R2; Q86U18; Q86U19; Q96BF9; Q96ES1; A6PX14; B2RDQ8

UniProt Related Accession #

P01009

GenBank Nucleotide #

NM_000295.4

NCBI Official Full Name

alpha-1-antitrypsin

NCBI Official Synonym Full Names

serpin family A member 1

NCBI Official Symbol

SERPINA1

NCBI Official Synonym Symbols

PI; A1A; AAT; PI1; A1AT; PRO2275; alpha1AT

UniProt Protein Name

Alpha-1-antitrypsin

UniProt Synonym Protein Names

Alpha-1 protease inhibitor; Alpha-1-antiproteinase; Serpin A1

Protein Family

Alpha-1-antiproteinase

UniProt Gene Name

SERPINA1

UniProt Synonym Gene Names

AAT; PI; SPAAT

NCBI Protein Information

alpha-1-antitrypsin

NCBI Summary for SERPINA1

The protein encoded by this gene is secreted and is a serine protease inhibitor whose targets include elastase, plasmin, thrombin, trypsin, chymotrypsin, and plasminogen activator. Defects in this gene can cause emphysema or liver disease. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

UniProt Comments for SERPINA1

Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Irreversibly inhibits trypsin, chymotrypsin and plasminogen activator. The aberrant form inhibits insulin-induced NO synthesis in platelets, decreases coagulation time and has proteolytic activity against insulin and plasmin.

Research Articles on SERPINA1

1. hAAT inhibits DC activation and function, and it also attenuates autoimmunity and renal damage in the MRL/lpr lupus model

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-SERPINA1 antibody

Reference Product	PubMed Publications
PRTN3 antibody	>5 publications with SERPINA1 and PRTN3
PRSS3 antibody	>1 publications with SERPINA1 and PRSS3
CTSG antibody	>1 publications with SERPINA1 and CTSG

Pathways associated with anti-SERPINA1 antibody

Products by Pathway	Pathway Diagram
Complement And Coagulation Cascades Pathway antibodies	Complement And Coagulation Cascades Pathway Diagram
Complement And Coagulation Cascades Pathway antibodies	Complement And Coagulation Cascades Pathway Diagram
Complement And Coagulation Cascades Pathway antibodies	Complement And Coagulation Cascades Pathway Diagram
FOXA1 Transcription Factor Network Pathway antibodies	FOXA1 Transcription Factor Network Pathway Diagram
Hemostasis Pathway antibodies	Hemostasis Pathway Diagram
Platelet Activation, Signaling And Aggregation Pathway antibodies	Platelet Activation, Signaling And Aggregation Pathway Diagram
Platelet Degranulation Pathway antibodies	Platelet Degranulation Pathway Diagram
Response To Elevated Platelet Cytosolic Ca2+ Pathway antibodies	Response To Elevated Platelet Cytosolic Ca2+ Pathway Diagram

Diseases associated with anti-SERPINA1 antibody

Disease Name	Pubmed Publications
Lung Diseases Antibodies	>108 publications with SERPINA1 and Lung Diseases
alpha 1-Antitrypsin Deficiency Antibodies	>107 publications with SERPINA1 and alpha 1-Antitrypsin Deficiency
Liver Diseases Antibodies	>96 publications with SERPINA1 and Liver Diseases
Neoplasms Antibodies	>39 publications with SERPINA1 and Neoplasms
Pulmonary Disease, Chronic Obstructive Antibodies	>38 publications with SERPINA1 and Pulmonary Disease, Chronic Obstructive
Pulmonary Emphysema Antibodies	>30 publications with SERPINA1 and Pulmonary Emphysema
Inflammation Antibodies	>28 publications with SERPINA1 and Inflammation
Liver Cirrhosis Antibodies	>23 publications with SERPINA1 and Liver Cirrhosis
Cardiovascular Diseases Antibodies	>23 publications with SERPINA1 and Cardiovascular Diseases
Carcinoma, Hepatocellular Antibodies	>20 publications with SERPINA1 and Carcinoma, Hepatocellular

Organs/Tissues associated with anti-SERPINA1 antibody

Organ/Tissue Name	Pubmed Publications
Liver Antibodies	>92 publications with SERPINA1 and Liver
Blood Antibodies	>81 publications with SERPINA1 and Blood
Lung Antibodies	>55 publications with SERPINA1 and Lung
Skin Antibodies	>13 publications with SERPINA1 and Skin
Vascular Antibodies	>10 publications with SERPINA1 and Vascular
Kidney Antibodies	>9 publications with SERPINA1 and Kidney
Heart Antibodies	>9 publications with SERPINA1 and Heart
Pancreas Antibodies	>7 publications with SERPINA1 and Pancreas
Intestine Antibodies	>6 publications with SERPINA1 and Intestine
Bone Antibodies	>6 publications with SERPINA1 and Bone