Human Cellexp SIGLEC6 Active Protein – Cat# MBS845576

Siglec-6/CD327 (SIGLEC6) Human Cellexp Active Protein

Name: SIGLEC6 Active Protein; Siglec-6/CD327; Human Cellexp; MyBioSource
Brand: MyBioSource
SKU: MBS845576
Price: 310 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS845576

Sialic acid-binding Ig-like lectin 6 (SIGLEC6) is also known as CD antigen CD327; CD33 antigen-like 1 (CD33L or CD33L1); Obesity-binding protein 1 (OB-BP1). SIGLEC6 belongs to the immunoglobulin superfamily and SIGLEC (sialic acid binding Ig-like lectin)… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

Siglec-6/CD327 (SIGLEC6), Active Protein

Full Product Name

Human CellExp Siglec-6/CD327 Protein; Fc Tag

Product Gene Name

SIGLEC6 active protein

Product Synonym Gene Name

CD327

Product Synonym Names

SIGLEC6; CD327; CD33L; CD33L1; OBBP1; OB-BP1; CDw327

Host

HEK293 cells
Source: Human

Form/Format

Lyophilized powder

Purity/Purification

>92%

Preparation and Storage

Store at 4 degree C for 12 months.
Centrifuge the vial prior to opening.

Molecular Weight

60.3 kDa

OMIM

D86358 mRNA

3D Structure

ModBase 3D Structure for O43699

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Endotoxin Level

<1 EU/mug by LAL method

Biological Activity

Measured by its ability to bind biotinylated Neu5Ac alpha 2-6GalNAc alpha (sialyl-Tn).

Reconstitution

Reconstitute in sterile deionized water to a stock solution of 200 ug/mL. Solubilize for 30 to 60 minutes at room temperature with occasional gentle mixing. Carrier protein (0.1% (W/V) HSA or BSA) is recommended for further dilution and long term storage.

Amino Acid Range

Gln 16- Val 320

Applications Tested/Suitable for SIGLEC6 active protein

SDS-PAGE

Other Notes

Small volumes of SIGLEC6 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SIGLEC6 purchase

MBS845576 is an active protein targeting SIGLEC6. Also known as Human CellExp Siglec-6/CD327 Protein; Fc Tag. Host: HEK293 cells
Source: Human.

Additional Details

NCBI/Uniprot data below describe general gene information for SIGLEC6. It may not necessarily be applicable to this product.

NCBI GI #

294774548

NCBI GeneID

946

NCBI Accession #

NP_001171018.1

UniProt Primary Accession #

O43699

UniProt Secondary Accession #

O15388; O43700; A8MV71; B2RTS8; C9JBE5; F8WA78

UniProt Related Accession #

O43699

GenBank Nucleotide #

NM_001177547.2

NCBI Official Full Name

sialic acid-binding Ig-like lectin 6 isoform 4

NCBI Official Synonym Full Names

sialic acid binding Ig like lectin 6

NCBI Official Symbol

SIGLEC6

NCBI Official Synonym Symbols

CD327; CD33L; OBBP1; CD33L1; CD33L2; CDW327

UniProt Protein Name

Sialic acid-binding Ig-like lectin 6

UniProt Synonym Protein Names

CD33 antigen-like 1; CDw327; Obesity-binding protein 1; OB-BP1; CD_antigen: CD327

Protein Family

Sialic acid-binding Ig-like lectin

UniProt Gene Name

SIGLEC6

UniProt Synonym Gene Names

CD33L; CD33L1; OBBP1; Siglec-6; OB-BP1

NCBI Protein Information

sialic acid-binding Ig-like lectin 6

NCBI Summary for SIGLEC6

This gene encodes a member of the SIGLEC (sialic acid binding immunoglobulin-like lectin) family of proteins. The encoded transmembrane receptor binds sialyl-TN glycans and leptin. Placental expression of the encoded protein is upregulated in preeclampsia. [provided by RefSeq, Jul 2016]

UniProt Comments for SIGLEC6

SIGLEC6: Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 19q13.41

Cellular Component: integral to plasma membrane; membrane

Molecular Function: protein binding

Biological Process: cell-cell signaling

Research Articles on SIGLEC6

1. Siglec6 and leptin play a role in the aberrant properties characteristic of gestational trophoblastic disease, namely excess proliferation and invasion.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with SIGLEC6 active protein

Reference Product	PubMed Publications
LEP active protein	>1 publications with SIGLEC6 and LEP

Diseases associated with SIGLEC6 active protein

Disease Name	Pubmed Publications
Pre-Eclampsia Antibodies	>3 publications with SIGLEC6 and Pre-Eclampsia
Lung Neoplasms Antibodies	>1 publications with SIGLEC6 and Lung Neoplasms
Neoplasms Antibodies	>1 publications with SIGLEC6 and Neoplasms

Organs/Tissues associated with SIGLEC6 active protein

Organ/Tissue Name	Pubmed Publications
Placenta Antibodies	>5 publications with SIGLEC6 and Placenta
Uterus Antibodies	>2 publications with SIGLEC6 and Uterus