Cathepsin D (CTSD) Active Protein

Name: CTSD Active Protein; Cathepsin D; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS845602
Price: 315 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS845602

Cathepsin D is a lysosomal aspartyl protease composed of a protein dimer of disulfide-linked heavy and light chains; both produced from a single protein precursor. It is an estrogen-regulated protein associated with tissue breakdown. Levels of cathepsin D… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

Cathepsin D (CTSD), Active Protein

Full Product Name

Active Cathepsin D; Human Recombinant

Product Gene Name

CTSD active protein

Product Synonym Names

Procathepsin D; CTSD

Host

E Coli
Source: Human

Form/Format

Freeze-dried from proprietary buffer

Purity/Purification

>=80%

Preparation and Storage

Store at -20 degree C for 6 months.
Centrifuge the vial prior to opening.

Molecular Weight

45.1 kDa

OMIM

M11233 mRNA

3D Structure

ModBase 3D Structure for P07339

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Biological Activity

Specific activity >100 pmol/min/mg and IC50 = 0.32 pM

Results

Cathepsin D has specific activity >100 pmol/min/mg and IC50 = 0.32 pM

Reconstitution

Reconstitute to 1 mg/ml in water

Applications Tested/Suitable for CTSD active protein

SDS-PAGE

Other Notes

Small volumes of CTSD active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CTSD purchase

MBS845602 is an active protein targeting CTSD. Also known as Active Cathepsin D; Human Recombinant. Host: E Coli
Source: Human.

Additional Details

NCBI/Uniprot data below describe general gene information for CTSD. It may not necessarily be applicable to this product.

NCBI GI #

4503143

NCBI GeneID

1509

NCBI Accession #

NP_001900.1

UniProt Primary Accession #

P07339

UniProt Secondary Accession #

Q6IB57

UniProt Related Accession #

P07339

GenBank Nucleotide #

NM_001909.4

NCBI Official Full Name

cathepsin D preproprotein

NCBI Official Synonym Full Names

cathepsin D

NCBI Official Symbol

CTSD

NCBI Official Synonym Symbols

CPSD; CLN10; HEL-S-130P

UniProt Protein Name

Cathepsin D

Protein Family

Aspartic-type endopeptidase

UniProt Gene Name

CTSD

UniProt Synonym Gene Names

CPSD

NCBI Protein Information

cathepsin D

NCBI Summary for CTSD

This gene encodes a member of the A1 family of peptidases. The encoded preproprotein is proteolytically processed to generate multiple protein products. These products include the cathepsin D light and heavy chains, which heterodimerize to form the mature enzyme. This enzyme exhibits pepsin-like activity and plays a role in protein turnover and in the proteolytic activation of hormones and growth factors. Mutations in this gene play a causal role in neuronal ceroid lipofuscinosis-10 and may be involved in the pathogenesis of several other diseases, including breast cancer and possibly Alzheimer's disease. [provided by RefSeq, Nov 2015]

UniProt Comments for CTSD

CTSD: Acid protease active in intracellular protein breakdown. Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease. Consists of a light chain and a heavy chain. Belongs to the peptidase A1 family.

Protein type: Autophagy; EC 3.4.23.5; Motility/polarity/chemotaxis; Protease

Chromosomal Location of Human Ortholog: 11p15.5

Cellular Component: extracellular matrix; extracellular region; extracellular space; lipid raft; lysosomal lumen; lysosome

Molecular Function: aspartic-type endopeptidase activity; cysteine-type endopeptidase activity; protein binding; serine-type endopeptidase activity

Biological Process: antigen processing and presentation of exogenous peptide antigen via MHC class II; autophagy; collagen catabolic process; neutrophil degranulation; protein catabolic process; proteolysis

Disease: Ceroid Lipofuscinosis, Neuronal, 10

Research Articles on CTSD

1. Secreted PGRN is incorporated into cells via sortilin or cation-independent mannose 6-phosphate receptor, and facilitated the acidification of lysosomes and degradation of CTSDmat. Moreover, the change of PGRN levels led to a cell-type-specific increase of insoluble TDP-43. In the brain tissue of FTLD-TDP patients with PGRN deficiency, CTSD and phosphorylated TDP-43 accumulated in neurons

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with CTSD active protein

Reference Product	PubMed Publications
CTSB active protein	>22 publications with CTSD and CTSB
CST3 active protein	>5 publications with CTSD and CST3
PSAP active protein	>3 publications with CTSD and PSAP
INS active protein	>2 publications with CTSD and INS
CD4 active protein	>2 publications with CTSD and CD4
APP active protein	>2 publications with CTSD and APP
IGF2R active protein	>2 publications with CTSD and IGF2R
IGFBP4 active protein	>1 publications with CTSD and IGFBP4
FN1 active protein	>1 publications with CTSD and FN1

Pathways associated with CTSD active protein

Products by Pathway	Pathway Diagram
Adaptive Immune System Pathway antibodies	Adaptive Immune System Pathway Diagram
Ceramide Signaling Pathway antibodies	Ceramide Signaling Pathway Diagram
Degradation Of Collagen Pathway antibodies	Degradation Of Collagen Pathway Diagram
Degradation Of The Extracellular Matrix Pathway antibodies	Degradation Of The Extracellular Matrix Pathway Diagram
Direct P53 Effectors Pathway antibodies	Direct P53 Effectors Pathway Diagram
Extracellular Matrix Organization Pathway antibodies	Extracellular Matrix Organization Pathway Diagram
Immune System Pathway antibodies	Immune System Pathway Diagram
LKB1 Signaling Events Pathway antibodies	LKB1 Signaling Events Pathway Diagram
Lysosome Pathway antibodies	Lysosome Pathway Diagram
Lysosome Pathway antibodies	Lysosome Pathway Diagram

Diseases associated with CTSD active protein

Disease Name	Pubmed Publications
Nervous System Diseases Antibodies	>51 publications with CTSD and Nervous System Diseases
Neoplasms Antibodies	>41 publications with CTSD and Neoplasms
Disease Models, Animal Antibodies	>18 publications with CTSD and Disease Models, Animal
Inflammation Antibodies	>12 publications with CTSD and Inflammation
Liver Diseases Antibodies	>10 publications with CTSD and Liver Diseases
Breast Neoplasms Antibodies	>9 publications with CTSD and Breast Neoplasms
Drug Toxicity Antibodies	>9 publications with CTSD and Drug Toxicity
Necrosis Antibodies	>7 publications with CTSD and Necrosis
Fibrosis Antibodies	>6 publications with CTSD and Fibrosis
Cardiovascular Diseases Antibodies	>6 publications with CTSD and Cardiovascular Diseases

Organs/Tissues associated with CTSD active protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>32 publications with CTSD and Blood
Brain Antibodies	>26 publications with CTSD and Brain
Liver Antibodies	>16 publications with CTSD and Liver
Muscle Antibodies	>15 publications with CTSD and Muscle
Lung Antibodies	>10 publications with CTSD and Lung
Kidney Antibodies	>8 publications with CTSD and Kidney
Vascular Antibodies	>8 publications with CTSD and Vascular
Eye Antibodies	>6 publications with CTSD and Eye
Bone Antibodies	>6 publications with CTSD and Bone
Nerve Antibodies	>4 publications with CTSD and Nerve