MAGEA3 Recombinant Protein

Name: MAGEA3 Recombinant Protein; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS845617
Price: 310 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS845617

Melanoma-associated antigen 3; also known MAGEA3; is a member of the MAGE gene family; which comprises 12 known genes; of which 6 are expressed in tumors. The MAGE genes were initially isolated from different kinds of tumors; and based on their virtually… More details

DISCONTINUED
Click here to view our similar product(s) OR click here to contact our technical support team for suitable replacement.

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

MAGEA3, Recombinant Protein

Full Product Name

MAGEA3; human recombinant

Product Gene Name

MAGEA3 recombinant protein

Product Synonym Names

CT1.3; HIP8; HYPD; MAGE3; MZ2 D

Sequence

MGSSHHHHHH SSGLVPRGSH MGSMPLEQRS QHCKPEEGLE ARGEALGLVG AQAPATEEQE AASSSSTLVE VTLGEVPAAE SPDPPQSPQG ASSLPTTMNY PLWSQSYEDS SNQEEEGPST FPDLESEFQA ALSRKVAELV HFLLLKYRAR EPVTKAEMLG SVVGNWQYFF PVIFSKASSS LQLVFGIELM EVDPIGHLYI FATCLGLSYD GLLGDNQIMP KAGLLIIVLA IIAREGDCAP EEKIWEELSV LEVFEGREDS ILGDPKKLLT QHFVQENYLE YRQVPGSDPA CYEFLWGPRA LVETSYVKVL HHMVKISGGP HISYPPLHEW VLREGEE

Host

E Coli
Source: Human

Form/Format

Liquid

Purity/Purification

>=90%

Concentration

1 mg/ml (lot specific)

Preparation and Storage

Store at -20 degree C for 12 months.
Centrifuge the vial prior to opening.

Molecular Weight

37.1 kDa

OMIM

U03735 Genomic DNA

3D Structure

ModBase 3D Structure for P43357

Tag Information

This protein is fused with a 6× His tag at N-terminus.

Reconstitution

In 20 mM Tris-HCl buffer (pH8.0) containing 1mM DTT; 10% glycerol; 100mM NaCl

Applications Tested/Suitable for MAGEA3 recombinant protein

SDS-PAGE

Other Notes

Small volumes of MAGEA3 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MAGEA3 purchase

MBS845617 is a recombinant protein targeting MAGEA3. Also known as MAGEA3; human recombinant. Host: E Coli
Source: Human.

Additional Details

NCBI/Uniprot data below describe general gene information for MAGEA3. It may not necessarily be applicable to this product.

NCBI GI #

4885467

NCBI GeneID

4102

NCBI Accession #

NP_005353.1

UniProt Primary Accession #

P43357

UniProt Secondary Accession #

Q6FHI6

UniProt Related Accession #

P43357

GenBank Nucleotide #

NM_005362.3

NCBI Official Full Name

melanoma-associated antigen 3

NCBI Official Synonym Full Names

MAGE family member A3

NCBI Official Symbol

MAGEA3

NCBI Official Synonym Symbols

HIP8; HYPD; CT1.3; MAGE3; MAGEA6

UniProt Protein Name

Melanoma-associated antigen 3

UniProt Synonym Protein Names

Antigen MZ2-D; Cancer/testis antigen 1.3; CT1.3; MAGE-3 antigen

Protein Family

Melanoma-associated antigen

UniProt Gene Name

MAGEA3

UniProt Synonym Gene Names

MAGE3; CT1.3

NCBI Protein Information

melanoma-associated antigen 3

NCBI Summary for MAGEA3

This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. [provided by RefSeq, Jul 2008]

UniProt Comments for MAGEA3

MAGEA3: Proposed to enhance ubiquitin ligase activity of RING- type zinc finger-containing E3 ubiquitin-protein ligases. May enhance ubiquitin ligase activity of TRIM28 and stimulate p53/TP53 ubiquitination by TRIM28. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in embryonal development and tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes.

Protein type: Cancer Testis Antigen (CTA)

Chromosomal Location of Human Ortholog: Xq28

Cellular Component: endoplasmic reticulum

Molecular Function: protein binding

Biological Process: negative regulation of caspase activity

Research Articles on MAGEA3

1. MAGEA3 was overexpressed in colorectal cancer tissue compared with healthy colon. MAGEA3 expression positively correlated with colorectal cancer progression.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with MAGEA3 recombinant protein

Reference Product	PubMed Publications
HLA-A recombinant protein	>94 publications with MAGEA3 and HLA-A
MLANA recombinant protein	>56 publications with MAGEA3 and MLANA
GAGE2A recombinant protein	>9 publications with MAGEA3 and GAGE2A
TRIM28 recombinant protein	>2 publications with MAGEA3 and TRIM28
SILV recombinant protein	>1 publications with MAGEA3 and SILV
BAGE2 recombinant protein	>1 publications with MAGEA3 and BAGE2

Diseases associated with MAGEA3 recombinant protein

Disease Name	Pubmed Publications
Melanoma Antibodies	>323 publications with MAGEA3 and Melanoma
Carcinoma Antibodies	>138 publications with MAGEA3 and Carcinoma
Neoplasm Metastasis Antibodies	>76 publications with MAGEA3 and Neoplasm Metastasis
Lung Neoplasms Antibodies	>56 publications with MAGEA3 and Lung Neoplasms
Lung Diseases Antibodies	>55 publications with MAGEA3 and Lung Diseases
Adenocarcinoma Antibodies	>51 publications with MAGEA3 and Adenocarcinoma
Head and Neck Neoplasms Antibodies	>42 publications with MAGEA3 and Head and Neck Neoplasms
Carcinoma, Squamous Cell Antibodies	>37 publications with MAGEA3 and Carcinoma, Squamous Cell
Carcinoma, Non-Small-Cell Lung Antibodies	>34 publications with MAGEA3 and Carcinoma, Non-Small-Cell Lung
Bronchial Neoplasms Antibodies	>32 publications with MAGEA3 and Bronchial Neoplasms

Organs/Tissues associated with MAGEA3 recombinant protein

Organ/Tissue Name	Pubmed Publications
Testis Antibodies	>112 publications with MAGEA3 and Testis
Lung Antibodies	>61 publications with MAGEA3 and Lung
Skin Antibodies	>55 publications with MAGEA3 and Skin
Lymph Node Antibodies	>49 publications with MAGEA3 and Lymph Node
Liver Antibodies	>33 publications with MAGEA3 and Liver
Bone Antibodies	>14 publications with MAGEA3 and Bone
Placenta Antibodies	>12 publications with MAGEA3 and Placenta
Brain Antibodies	>11 publications with MAGEA3 and Brain
Salivary Gland Antibodies	>3 publications with MAGEA3 and Salivary Gland
Prostate Antibodies	>3 publications with MAGEA3 and Prostate