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R428 (1- (6)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS845771

R428 is a potent and selective small-molecule inhibitor (IC50 = 14 nM) of the receptor tyrosine kinase Axl. R428 blocks Axl-dependent events; including Akt phosphorylation; breast cancer cell invasion; and proinflammatory cytokine production. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
R428, Biochemical
Full Product Name
R428
Product Gene Name
R428 biochemical
Product Synonym Names
1- (6; 7-dihydro-5H-benzo[6; 7]cyclohepta[1; 2-c]pyridazin-3-yl)-N3- (7- (pyrrolidin-1-yl)-6; 7; 8; 9-tetrahydro-5H-benzo[7]annulen-2-yl)-1H-1; 2; 4-triazole-3; 5-diamine; BGB324
Form/Format
Crystalline solid
Purity/Purification
>=98% by HPLC
Preparation and Storage
Store at -20 degree C for 36 months.
Protect from air and light.
Molecular Weight
506.64
Salt Form
No
CAS Number
1037624-75-1
Cell-Permeable
Yes
Reconstitution
DMSO (>5 mg/ml)
SMILES
C1CCN(C1)C2CCC3=C(CC2)C=C(C=C3)NC4=NN(C(=N4)N)C5=NN=C6C(=C5)CCCC7=CC=CC=C76
InChi
InChI=1S/C30H34N8/c31-29-33-30(32-24-13-10-20-11-14-25(15-12-22(20)18-24)37-16-3-4-17-37)36-38(29)27-19-23-8-5-7-21-6-1-2-9-26(21)28(23)35-34-27/h1-2,6,9-10,13,18-19,25H,3-5,7-8,11-12,14-17H2,(H3,31,32,33,36)/t25-/m0/s1
InChi Key
KXMZDGSRSGHMMK-VWLOTQADSA-N

Structure of R428 biochemical

R428 1- (6 Biochemical – Cat# MBS845771

Other Notes

Small volumes of R428 biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for R428 purchase

MBS845771 is a biochemical targeting R428.
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