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JH-II-127

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS845811

JH-II-127 is a highly potent; selective; and cell-permeable LRRK2 inhibitor; with IC50 of 6.6 nM; 2.2 nM; 47.7 nM for LRRK2-wild-type; LRRK2-G2019S; LRRK2-A2016T. JH-II-127 substantially inhibits Ser910 and Ser935 phosphorylation of both wild-type LRRK2 and… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
JH-II-127, Biochemical
Full Product Name
JH-II-127
Product Gene Name
Product Synonym Names
4- ( (5-chloro-4- (methylamino)-7H-pyrrolo[2; 3-d]pyrimidin-2-yl) amino)-3-methoxyphenyl) (morpholino) methanone
Form/Format
Crystalline solid
Purity/Purification
>=98% by HPLC
Preparation and Storage
Store at -20 degree C for 36 months.
Protect from air and light.
Molecular Weight
416.87
Salt Form
No
Molecular Formula
C19H21ClN6O2
CAS Number
1700693-08-8 
Cell-Permeable
Yes
Reconstitution
DMSO (>20 mg/ml)

Other Notes

Small volumes of JH-II-127 biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for JH-II-127 purchase

MBS845811 is a biochemical targeting JH-II-127.

Additional Details

NCBI/Uniprot data below describe general gene information for JH-II-127. It may not necessarily be applicable to this product.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.
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