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EDG4 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS845934

Polyclonal antibody against EDG4.EDG4 is a member of family I of the G protein-coupled receptors; as well as the EDG family of proteins. This protein functions as a lysophosphatidic acid (LPA) receptor and contributes to Ca2+ mobilization; a critical cellular… More details

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Product Overview

Product Name
EDG4, Polyclonal Antibody
Full Product Name
EDG4 Antibody (NT)
Product Gene Name
anti-EDG4 antibody
Product Synonym Names
Lysophosphatidic acid receptor 2; LPA receptor 2; LPA-2; Lysophosphatidic acid receptor Edg-4; LPAR2; EDG4; LPA2
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Monkey
Form/Format
Colorless liquid
100 ug (0.5 mg/ml) of antibody in PBS with 0.09% (W/V) sodium azide.
Concentration
1 mg/ml (lot specific)
Preparation and Storage
Store at -20 degree C for 12 months.
The antibody solution should be gently mixed before use.
Molecular Weight
39,084 Da
OMIM
AF011466 mRNA
3D Structure
ModBase 3D Structure for Q9HBW0
Immunogen
KLH conjugated synthetic peptide between 3-32 amino acids from the N-terminal region of human EDG4

Product Categories/Family for anti-EDG4 antibody

GPCR
Applications Tested/Suitable for anti-EDG4 antibody
Western Blot (WB); Immunohistochemistry (IHC)
Application Notes for anti-EDG4 antibody
WB: 1:1000
IHC: 1:50~100

Other Notes

Small volumes of anti-EDG4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for EDG4 purchase

MBS845934 is an antibody targeting EDG4. Also known as EDG4 Antibody (NT). Reactive in Human, Monkey. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for EDG4. It may not necessarily be applicable to this product.

NCBI GI #
7305013
NCBI GeneID
9170
NCBI Accession #
NP_004711.2
UniProt Primary Accession #
Q9HBW0
UniProt Secondary Accession #
O00543; O43431
UniProt Related Accession #
Q9HBW0
GenBank Nucleotide #
NM_004720.5
NCBI Official Full Name
lysophosphatidic acid receptor 2
NCBI Official Synonym Full Names
lysophosphatidic acid receptor 2
NCBI Official Symbol
LPAR2
NCBI Official Synonym Symbols
EDG4; LPA2; EDG-4; LPA-2
UniProt Protein Name
Lysophosphatidic acid receptor 2
UniProt Synonym Protein Names
Lysophosphatidic acid receptor Edg-4
UniProt Gene Name
LPAR2
UniProt Synonym Gene Names
EDG4; LPA2; LPA receptor 2; LPA-2
NCBI Protein Information
lysophosphatidic acid receptor 2

NCBI Summary for EDG4

This gene encodes a member of family I of the G protein-coupled receptors, as well as the EDG family of proteins. This protein functions as a lysophosphatidic acid (LPA) receptor and contributes to Ca2+ mobilization, a critical cellular response to LPA in cells, through association with Gi and Gq proteins. An alternative splice variant has been described but its full length sequence has not been determined. [provided by RefSeq, Jul 2008]
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UniProt Comments for EDG4

EDG4: Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Seems to be coupled to the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Plays a key role in phospholipase C-beta (PLC-beta) signaling pathway. Stimulates phospholipase C (PLC) activity in a manner that is independent of RALA activation. Belongs to the G-protein coupled receptor 1 family.

Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR

Chromosomal Location of Human Ortholog: 19p13.11

Cellular Component: cell surface; endocytic vesicle; integral to plasma membrane; plasma membrane

Molecular Function: G-protein coupled receptor activity; lipid binding; protein binding

Biological Process: elevation of cytosolic calcium ion concentration; phospholipase C activation
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Research Articles on EDG4

1. epithelial dysplasia was observed in founder mouse intestine, correlating LPA2 overexpression with epithelial dysplasia. The current study demonstrates that overexpression of LPA2 alone can lead to intestinal dysplasia.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-EDG4 antibody

 Products by Pathway  Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 G Alpha (q) Signalling Events Pathway antibodies  G Alpha (q) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 Gastrin-CREB Signalling Pathway Via PKC And MAPK antibodies  Gastrin-CREB Signalling Pathway Via PKC And MAPK Diagram
 LPA Receptor Mediated Events Pathway antibodies  LPA Receptor Mediated Events Pathway Diagram
 Lysosphingolipid And LPA Receptors Pathway antibodies  Lysosphingolipid And LPA Receptors Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram

Diseases associated with anti-EDG4 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >4 publications with EDG4 and Neoplasms
 Inflammation Antibodies  >2 publications with EDG4 and Inflammation
 Liver Diseases Antibodies  >2 publications with EDG4 and Liver Diseases
 Adenocarcinoma Antibodies  >2 publications with EDG4 and Adenocarcinoma
 Hypertension Antibodies  >1 publications with EDG4 and Hypertension
 Lung Diseases Antibodies  >1 publications with EDG4 and Lung Diseases
 Carcinoma, Hepatocellular Antibodies  >1 publications with EDG4 and Carcinoma, Hepatocellular
 Death Antibodies  >1 publications with EDG4 and Death
 Cardiovascular Diseases Antibodies  >1 publications with EDG4 and Cardiovascular Diseases
 Necrosis Antibodies  >1 publications with EDG4 and Necrosis

Organs/Tissues associated with anti-EDG4 antibody

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >3 publications with EDG4 and Liver
 Placenta Antibodies  >1 publications with EDG4 and Placenta
 Ovary Antibodies  >1 publications with EDG4 and Ovary
 Intestine Antibodies  >1 publications with EDG4 and Intestine
 Uterus Antibodies  >1 publications with EDG4 and Uterus
 Blood Antibodies  >1 publications with EDG4 and Blood
 Embryonic Tissue Antibodies  >1 publications with EDG4 and Embryonic Tissue
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