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5-Hydroxytryptamine Receptor 1a (HTR1A) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS845937

Polyclonal antibody against EDG7.Serotonin [5-hydroxytryptamine (5-HT1) ] is an important neurotransmitter in the CNS that exerts its neuronal activity via 5-HT receptors. 5-HT receptors are subdivided into seven families termed 5-HT1 through 5-HT7.1 The 5-HT… More details

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Product Overview

Product Name
5-Hydroxytryptamine Receptor 1A (Htr1a), Polyclonal Antibody
Full Product Name
5-Hydroxytryptamine Receptor 1A Antibody
Product Gene Name
anti-Htr1a antibody
Product Synonym Names
5-hydroxytryptamine receptor 1A; 5-HT-1A; 5-HT1A; Serotonin receptor 1A; Htr1a; 5ht1a
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Mouse, Rat
Form/Format
Colorless liquid
100 ug (0.5 mg/ml) of antibody in PBS; pH 7.4; 1% BSA; 0.05% NaN3.
Purity/Purification
Affinity Purified
Concentration
1 mg/ml (lot specific)
Preparation and Storage
Store at -20 degree C for 12 months.
The antibody solution should be gently mixed before use.
Molecular Weight
46,429 Da
3D Structure
ModBase 3D Structure for P19327
Immunogen
Peptide KKSLNGQPGSGDWRRC; corresponding to amino acid residues 251-266 of rat 5-Hydroxytryptamine Receptor 1A (Accession P19327). 3rd intracellular loop.Will not recognize human 5-Hydroxytryptamine Receptor 1A.

Product Categories/Family for anti-Htr1a antibody

GPCR
Applications Tested/Suitable for anti-Htr1a antibody
Western Blot (WB); Immunohistochemistry (IHC)
Application Notes for anti-Htr1a antibody
WB: 1:200-1:2000
IHC: 1:100

Other Notes

Small volumes of anti-Htr1a antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Htr1a purchase

MBS845937 is an antibody targeting Htr1a. Also known as 5-Hydroxytryptamine Receptor 1A Antibody. Reactive in Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for Htr1a. It may not necessarily be applicable to this product.

NCBI GI #
6981054
NCBI GeneID
24473
NCBI Accession #
NP_036717.1
UniProt Primary Accession #
P19327
UniProt Related Accession #
P19327
GenBank Nucleotide #
NM_012585.1
NCBI Official Full Name
5-hydroxytryptamine receptor 1A
NCBI Official Synonym Full Names
5-hydroxytryptamine receptor 1A
NCBI Official Symbol
Htr1a
NCBI Official Synonym Symbols
5HT1A; RAT5HT1A
UniProt Protein Name
5-hydroxytryptamine receptor 1A
UniProt Synonym Protein Names
Serotonin receptor 1A
Protein Family
5-hydroxytryptamine receptor
UniProt Gene Name
Htr1a
UniProt Synonym Gene Names
5ht1a; 5-HT-1A; 5-HT1A
NCBI Protein Information
5-hydroxytryptamine receptor 1A

NCBI Summary for Htr1a

regulates AMPA receptor channels in the prefrontal cortex; regulation is mediated via inhibition of Ca2+/calmodulin-dependent kinase II [RGD, Feb 2006]

UniProt Comments for Htr1a

5-HT(1A): This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Belongs to the G-protein coupled receptor 1 family. 5- hydroxytryptamine receptor subfamily. HTR1A sub-subfamily.

Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR

Chromosomal Location of Human Ortholog: 2q13

Cellular Component: axon hillock; cell soma; integral to plasma membrane; membrane

Molecular Function: drug binding; G-protein alpha-subunit binding; neurotransmitter receptor activity; protein binding; receptor binding; serotonin binding; serotonin receptor activity

Biological Process: behavioral fear response; G-protein coupled receptor protein signaling pathway; positive regulation of microtubule depolymerization; regulation of dopamine metabolic process; regulation of serotonin secretion; serotonin metabolic process; serotonin receptor signaling pathway; serotonin receptor, adenylate cyclase inhibiting pathway
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Research Articles on Htr1a

1. Study showed that maternal exposure to chronic footshock stress increases the intensity of diazepam withdrawal symptoms and significantly reduce levels of 5HT1A receptors in the raphe nuclei of adult offspring, suggesting that prenatal stress may increase vulnerability to drugs

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-Htr1a antibody

 Products by Pathway  Pathway Diagram
 Amine Ligand-binding Receptors Pathway antibodies  Amine Ligand-binding Receptors Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Class A Rhodopsin-like Pathway antibodies  GPCRs, Class A Rhodopsin-like Pathway Diagram
 Monoamine GPCRs Pathway antibodies  Monoamine GPCRs Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Serotonergic Synapse Pathway antibodies  Serotonergic Synapse Pathway Diagram

Diseases associated with anti-Htr1a antibody

 Disease Name  Pubmed Publications
 Mental Disorders Antibodies  >101 publications with Htr1a and Mental Disorders
 Mood Disorders Antibodies  >56 publications with Htr1a and Mood Disorders
 Depressive Disorder Antibodies  >55 publications with Htr1a and Depressive Disorder
 Depressive Disorder, Major Antibodies  >47 publications with Htr1a and Depressive Disorder, Major
 Anxiety Disorders Antibodies  >30 publications with Htr1a and Anxiety Disorders
 Bipolar Disorder Antibodies  >12 publications with Htr1a and Bipolar Disorder
 Panic Disorder Antibodies  >10 publications with Htr1a and Panic Disorder
 Personality Disorders Antibodies  >9 publications with Htr1a and Personality Disorders
 Pain Antibodies  >6 publications with Htr1a and Pain
 Cognition Disorders Antibodies  >3 publications with Htr1a and Cognition Disorders

Organs/Tissues associated with anti-Htr1a antibody

 Organ/Tissue Name  Pubmed Publications
 Mixed Antibodies  >5 publications with Htr1a and Mixed
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