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CXCR-7 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS845944

Polyclonal Antibody against AGTR5.Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades; resulting instead in chemokine… More details

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Product Overview

Product Name
CXCR-7, Polyclonal Antibody
Full Product Name
CXCR-7 Polyclonal Antibody
Product Gene Name
anti-CXCR-7 antibody
Product Synonym Gene Name
ACKR3
Product Synonym Names
ACKR3; CXCR7; CMKOR1; GPR159; RDC1; C-X-C chemokine receptor type 7; CXC-R7; CXCR-7; Chemokine orphan receptor 1; G-protein coupled receptor 159; G-protein coupled receptor RDC1 homolog; RDC-1
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat, Monkey
Form/Format
Colorless liquid
100 ug (1mg/ml) of antibody containing 50% glycerol; 0.5% BSA and 0.02% sodium azide
Concentration
1 mg/ml (lot specific)
Preparation and Storage
Store at -20 degree C for 12 months.
The antibody solution should be gently mixed before use.
Molecular Weight
41,493 Da
OMIM
M64749 mRNA
3D Structure
ModBase 3D Structure for P25106
Immunogen
Synthesized peptide derived from the C-terminal region of human CXCR-7 (290-370aa)

Product Categories/Family for anti-CXCR-7 antibody

GPCR
Applications Tested/Suitable for anti-CXCR-7 antibody
Western Blot (WB); Immunohistochemistry (IHC); ELISA (EIA)
Application Notes for anti-CXCR-7 antibody
WB: 1:500-1:2000
IF: 1:200-1:1000
ELISA: 1:20000

Other Notes

Small volumes of anti-CXCR-7 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CXCR-7 purchase

MBS845944 is an antibody targeting CXCR-7. Also known as CXCR-7 Polyclonal Antibody. Reactive in Human, Mouse, Rat, Monkey. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CXCR-7. It may not necessarily be applicable to this product.

NCBI GI #
31083344
NCBI GeneID
57007
NCBI Accession #
NP_064707.1
UniProt Primary Accession #
P25106
UniProt Secondary Accession #
Q53RV4; Q8NE10; Q92938; Q92986; A8K6J4
UniProt Related Accession #
P25106
GenBank Nucleotide #
NM_020311.2
NCBI Official Full Name
atypical chemokine receptor 3
NCBI Official Synonym Full Names
atypical chemokine receptor 3
NCBI Official Symbol
ACKR3
NCBI Official Synonym Symbols
RDC1; CXCR7; RDC-1; CMKOR1; CXC-R7; CXCR-7; GPR159
UniProt Protein Name
Atypical chemokine receptor 3
UniProt Synonym Protein Names
C-X-C chemokine receptor type 7; CXC-R7; CXCR-7; Chemokine orphan receptor 1; G-protein coupled receptor 159; G-protein coupled receptor RDC1 homolog; RDC-1
Protein Family
Atypical chemokine receptor
UniProt Gene Name
ACKR3
UniProt Synonym Gene Names
CMKOR1; CXCR7; GPR159; RDC1; CXC-R7; CXCR-7; RDC-1
NCBI Protein Information
atypical chemokine receptor 3

NCBI Summary for CXCR-7

This gene encodes a member of the G-protein coupled receptor family. Although this protein was earlier thought to be a receptor for vasoactive intestinal peptide (VIP), it is now considered to be an orphan receptor, in that its endogenous ligand has not been identified. The protein is also a coreceptor for human immunodeficiency viruses (HIV). Translocations involving this gene and HMGA2 on chromosome 12 have been observed in lipomas. [provided by RefSeq, Jul 2008]
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UniProt Comments for CXCR-7

CMKOR1: Receptor for chemokines CXCL12/SDF1 and CXCL11. Does not elicit classical chemokine receptor signaling; chemokine binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalization and activation of MAPK signaling pathway. Acts as a scavenger for CXCL12/SDF1 and, to a lesser extent, for CXCL11. Required for regulation of CXCR4 protein levels in migrating interneurons, thereby adapting their chemokine responsiveness. In glioma cells, transduces signals via MEK/ERK pathway, mediating resistance to apoptosis. Promotes cell growth and survival. Not involved in cell migration, adhesion or proliferation of normal hematopoietic progenitors but activated by CXCL11 in malignant hemapoietic cells, leading to phosphorylation of ERK1/2 (MAPK3/MAPK1) and enhanced cell adhesion and migration. Plays a regulatory role in CXCR4-mediated activation of cell surface integrins by CXCL12. Required for heart valve development. Acts as coreceptor with CXCR4 for a restricted number of HIV isolates. Belongs to the G-protein coupled receptor 1 family.

Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR

Chromosomal Location of Human Ortholog: 2q37.3

Cellular Component: cell surface; coated pit; endosome; intracellular membrane-bound organelle; plasma membrane

Molecular Function: C-X-C chemokine binding; C-X-C chemokine receptor activity; protein binding; scavenger receptor activity

Biological Process: receptor internalization
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Research Articles on CXCR-7

1. CXCR7 expression in the tumor cells and stromal cells from the metastatic foci was significantly more common in the group of male patients treated with cytotoxic drugs according to the FOLFOX6 regimen

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-CXCR-7 antibody

 Products by Pathway  Pathway Diagram
 Chemokine Receptors Bind Chemokines Pathway antibodies  Chemokine Receptors Bind Chemokines Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Class A Rhodopsin-like Pathway antibodies  GPCRs, Class A Rhodopsin-like Pathway Diagram
 Myometrial Relaxation And Contraction Pathways antibodies  Myometrial Relaxation And Contraction Pathways Diagram
 Peptide Ligand-binding Receptors Pathway antibodies  Peptide Ligand-binding Receptors Pathway Diagram

Diseases associated with anti-CXCR-7 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >100 publications with CXCR-7 and Neoplasms
 Inflammation Antibodies  >37 publications with CXCR-7 and Inflammation
 Carcinoma Antibodies  >32 publications with CXCR-7 and Carcinoma
 Neoplasm Metastasis Antibodies  >29 publications with CXCR-7 and Neoplasm Metastasis
 Breast Neoplasms Antibodies  >23 publications with CXCR-7 and Breast Neoplasms
 Adenocarcinoma Antibodies  >17 publications with CXCR-7 and Adenocarcinoma
 Nervous System Diseases Antibodies  >14 publications with CXCR-7 and Nervous System Diseases
 Lung Neoplasms Antibodies  >12 publications with CXCR-7 and Lung Neoplasms
 Neoplasms, Experimental Antibodies  >11 publications with CXCR-7 and Neoplasms, Experimental
 Kidney Diseases Antibodies  >11 publications with CXCR-7 and Kidney Diseases

Organs/Tissues associated with anti-CXCR-7 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >35 publications with CXCR-7 and Brain
 Bone Antibodies  >29 publications with CXCR-7 and Bone
 Lung Antibodies  >22 publications with CXCR-7 and Lung
 Bone Marrow Antibodies  >22 publications with CXCR-7 and Bone Marrow
 Kidney Antibodies  >19 publications with CXCR-7 and Kidney
 Lymph Antibodies  >15 publications with CXCR-7 and Lymph
 Embryonic Tissue Antibodies  >14 publications with CXCR-7 and Embryonic Tissue
 Nerve Antibodies  >9 publications with CXCR-7 and Nerve
 Heart Antibodies  >8 publications with CXCR-7 and Heart
 Prostate Antibodies  >7 publications with CXCR-7 and Prostate
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