Histone H2B (H2B) Antibody – Rabbit Monoclonal

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2B family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the histone microcluster on chromosome 6p21.33. [provided by RefSeq, Aug 2015]

HIST1H2BJ: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Belongs to the histone H2B family.

Chromosomal Location of Human Ortholog: 6p22.1

Cellular Component: cytosol; extracellular space; nucleoplasm; nucleus; plasma membrane

Molecular Function: DNA binding; lipopolysaccharide binding

Biological Process: antibacterial humoral response; defense response to Gram-negative bacterium; defense response to Gram-positive bacterium; innate immune response in mucosa; killing of cells of another organism; nucleosome assembly; protein ubiquitination