Rabbit Anti-ANAPC1 Polyclonal Antibody – Cat# MBS846034

ANAPC1 Antibody – Rabbit Polyclonal

Name: ANAPC1 Antibody; Polyclonal; Rabbit; Human/Mouse-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS846034
Price: 460 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS846034

Polyclonal antibody to detect endogenous levels of ANAPC1 (pS688) in human and mouse.Component of the anaphase promoting complex/cyclosome (APC/C); a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

ANAPC1, Polyclonal Antibody

Full Product Name

Phospho-ANAPC1 (Ser688) Antibody

Product Gene Name

anti-ANAPC1 antibody

Product Synonym Names

TSG24; Anaphase-promoting complex subunit 1; APC1; Cyclosome subunit 1; Mitotic checkpoint regulator; Testis-specific gene 24 protein

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human, Mouse

Form/Format

Colorless liquid
In 0.42% Potassium phosphate; 0.87% Sodium chloride; pH 7.3; 30% glycerol and 0.01% sodium azide

Purity/Purification

Affinity Purified

Preparation and Storage

Store at -20 degree C for 12 months.
The antibody solution should be gently mixed before use.

Molecular Weight

216,500 Da

OMIM

AJ278357 mRNA

3D Structure

ModBase 3D Structure for Q9H1A4

Immunogen

KLH-conjugated synthetic peptide encompassing a sequence within the center region of human ANAPC1

Applications Tested/Suitable for anti-ANAPC1 antibody

Western Blot (WB); Immunohistochemistry (IHC); Immunofluorescence (IF); Immunocytochemistry (ICC)

Application Notes for anti-ANAPC1 antibody

WB: 1:500- 1:2000
IHC: 1:50- 1:200
IF/IC: 1:50- 1:100

Other Notes

Small volumes of anti-ANAPC1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ANAPC1 purchase

MBS846034 is an antibody targeting ANAPC1. Also known as Phospho-ANAPC1 (Ser688) Antibody. Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for ANAPC1. It may not necessarily be applicable to this product.

NCBI GI #

12056971

NCBI GeneID

64682

NCBI Accession #

NP_073153.1

UniProt Primary Accession #

Q9H1A4

UniProt Secondary Accession #

Q2M3H8; Q9BSE6; Q9H8D0

UniProt Related Accession #

Q9H1A4

GenBank Nucleotide #

NM_022662.3

NCBI Official Full Name

anaphase-promoting complex subunit 1

NCBI Official Synonym Full Names

anaphase promoting complex subunit 1

NCBI Official Symbol

ANAPC1

NCBI Official Synonym Symbols

APC1; MCPR; TSG24

UniProt Protein Name

Anaphase-promoting complex subunit 1

UniProt Synonym Protein Names

Cyclosome subunit 1; Mitotic checkpoint regulator; Testis-specific gene 24 protein

UniProt Gene Name

ANAPC1

UniProt Synonym Gene Names

TSG24; APC1

NCBI Protein Information

anaphase-promoting complex subunit 1

NCBI Summary for ANAPC1

This gene encodes a subunit of the anaphase-promoting complex. This complex is an E3 ubiquitin ligase that regulates progression through the metaphase to anaphase portion of the cell cycle by ubiquitinating proteins which targets them for degradation. [provided by RefSeq, Dec 2011]

UniProt Comments for ANAPC1

APC1: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Belongs to the APC1 family.

Protein type: Cell cycle regulation; Ubiquitin conjugating system

Chromosomal Location of Human Ortholog: 2q13

Cellular Component: anaphase-promoting complex; cytosol; nucleoplasm

Biological Process: anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; proteasomal ubiquitin-dependent protein catabolic process; protein ubiquitination during ubiquitin-dependent protein catabolic process; regulation of ubiquitin-protein ligase activity during mitotic cell cycle

Research Articles on ANAPC1

1. findings suggest a tumor suppressor role for APC/C(Cdh1) in melanocytes and that targeting PAX3 may be a strategy for treating melanoma.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-ANAPC1 antibody

Products by Pathway	Pathway Diagram
APC/C Complex Pathway antibodies	APC/C Complex Pathway Diagram
APC/C Complex Pathway antibodies	APC/C Complex Pathway Diagram
APC/C-mediated Degradation Of Cell Cycle Proteins Pathway antibodies	APC/C-mediated Degradation Of Cell Cycle Proteins Pathway Diagram
APC/C:Cdc20 Mediated Degradation Of Cyclin B Pathway antibodies	APC/C:Cdc20 Mediated Degradation Of Cyclin B Pathway Diagram
APC/C:Cdc20 Mediated Degradation Of Securin Pathway antibodies	APC/C:Cdc20 Mediated Degradation Of Securin Pathway Diagram
APC/C:Cdc20 Mediated Degradation Of Mitotic Proteins Pathway antibodies	APC/C:Cdc20 Mediated Degradation Of Mitotic Proteins Pathway Diagram
APC/C:Cdh1 Mediated Degradation Of Cdc20 And Other APC/C:Cdh1 Targeted Proteins In Late Mitosis/early G1 Pathway antibodies	APC/C:Cdh1 Mediated Degradation Of Cdc20 And Other APC/C:Cdh1 Targeted Proteins In Late Mitosis/early G1 Pathway Diagram
Activation Of APC/C And APC/C:Cdc20 Mediated Degradation Of Mitotic Proteins Pathway antibodies	Activation Of APC/C And APC/C:Cdc20 Mediated Degradation Of Mitotic Proteins Pathway Diagram
Adaptive Immune System Pathway antibodies	Adaptive Immune System Pathway Diagram
Antigen Processing: Ubiquitination & Proteasome Degradation Pathway antibodies	Antigen Processing: Ubiquitination & Proteasome Degradation Pathway Diagram

Diseases associated with anti-ANAPC1 antibody

Disease Name	Pubmed Publications
Adenocarcinoma Antibodies	>1 publications with ANAPC1 and Adenocarcinoma

Organs/Tissues associated with anti-ANAPC1 antibody

Organ/Tissue Name	Pubmed Publications
Uterus Antibodies	>1 publications with ANAPC1 and Uterus
Stomach Antibodies	>1 publications with ANAPC1 and Stomach
Lung Antibodies	>1 publications with ANAPC1 and Lung