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ICK Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS846050

Polyclonal antibody to detect endogenous levels of ICK in human.Required for ciliogenesis. Phosphorylates KIF3A (By similarity). Involved in the control of ciliary length. Regulates the ciliary localization of SHH pathway components as well as the… More details

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Product Overview

Product Name
ICK, Polyclonal Antibody
Full Product Name
Anti-ICK Antibody
Product Gene Name
Product Synonym Names
KIAA0936; Serine/threonine-protein kinase ICK; Intestinal cell kinase; hICK; Laryngeal cancer kinase 2; LCK2; MAK-related kinase; MRK
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Colorless liquid
In 0.42% Potassium phosphate; 0.87% Sodium chloride; pH 7.3; 30% glycerol and 0.01% sodium azide
Purity/Purification
Affinity Purified
Preparation and Storage
Store at -20 degree C for 12 months.
The antibody solution should be gently mixed before use.
Molecular Weight
34,071 Da
OMIM
AF225919 mRNA
3D Structure
ModBase 3D Structure for Q9UPZ9
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within the center region of human ICK
Applications Tested/Suitable for anti-ICK antibody
Western Blot (WB); Immunohistochemistry (IHC); Immunofluorescence (IF); Immunocytochemistry (ICC)
Application Notes for anti-ICK antibody
WB: 1:500- 1:2000
IHC: 1:50- 1:200
IF/IC: 1:50- 1:100

Testing Data of anti-ICK antibody

Rabbit Anti-ICK Polyclonal Antibody – Cat# MBS846050

Other Notes

Small volumes of anti-ICK antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ICK purchase

MBS846050 is an antibody targeting ICK. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for ICK. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
serine/threonine-protein kinase ICK
NCBI Official Synonym Full Names
intestinal cell kinase
NCBI Official Symbol
ICK
NCBI Official Synonym Symbols
ECO; MRK; LCK2
UniProt Protein Name
Serine/threonine-protein kinase ICK
UniProt Synonym Protein Names
Intestinal cell kinase; hICK; Laryngeal cancer kinase 2; LCK2; MAK-related kinase; MRK
UniProt Gene Name
ICK
UniProt Synonym Gene Names
KIAA0936; hICK; LCK2; MRK
NCBI Protein Information
serine/threonine-protein kinase ICK

NCBI Summary for ICK

Eukaryotic protein kinases are enzymes that belong to a very extensive family of proteins which share a conserved catalytic core common with both serine/threonine and tyrosine protein kinases. This gene encodes an intestinal serine/threonine kinase harboring a dual phosphorylation site found in mitogen-activating protein (MAP) kinases. The protein localizes to the intestinal crypt region and is thought to be important in intestinal epithelial cell proliferation and differentiation. Alternative splicing has been observed at this locus and two variants, encoding the same isoform, have been identified. [provided by RefSeq, Jul 2008]
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UniProt Comments for ICK

ICK: a CMGC kinase of the RCK family. May play a role in cardiac development. Expressed in heart, brain, placenta, pancreas, thymus, prostate, testis, ovary, small intestine and colon. Also expressed in many cancer cell lines. Two alternatively spliced isoforms have been described.

Protein type: CMGC group; EC 2.7.11.22; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor); RCK family

Chromosomal Location of Human Ortholog: 6p12.1

Cellular Component: cilium; cytoplasm; nucleus

Molecular Function: ATP binding; magnesium ion binding; protein binding; protein serine/threonine kinase activity

Biological Process: intraflagellar transport; protein amino acid phosphorylation; regulation of gene expression; signal transduction

Disease: Endocrine-cerebroosteodysplasia
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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