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LY-2835219

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS846186

LY-2835219 is a potent and selective inhibitor of CDK4 and CDK6 with IC50 of 2 nM and 10 nM; respectively. LY-2835219 inhibits the proliferation of Rb-positive tumor cells and demonstrates dose-dependent growth inhibition in ER+ breast cancer models. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
LY-2835219, Biochemical
Full Product Name
LY-2835219
Product Gene Name
LY-2835219 biochemical
Product Synonym Names
N- (5- ( (4-ethylpiperazin-1-yl) methyl) pyridin-2-yl)-5-fluoro-4- (4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl) pyrimidin-2-amine; Abemaciclib
Form/Format
White to off-white solid
Purity/Purification
>=98% by HPLC
Preparation and Storage
Store at -20 degree C for 36 months.
Protect from air and moisture.
Molecular Weight
602.7
Salt Form
No
Molecular Formula
C27H32F2N8.CH4O3S
CAS Number
1231930-82-7
Cell-Permeable
Yes
Reconstitution
DMSO (>50 mg/ml) or H2O (>60 mg/ml)
SMILES
CCN1CCN(CC1)CC2=CN=C(C=C2)NC3=NC=C(C(=N3)C4=CC5=C(C(=C4)F)N=C(N5C(C)C)C)F.CS(=O)(=O)O
InChi
InChI=1S/C27H32F2N8.CH4O3S/c1-5-35-8-10-36(11-9-35)16-19-6-7-24(30-14-19)33-27-31-15-22(29)25(34-27)20-12-21(28)26-23(13-20)37(17(2)3)18(4)32-26;1-5(2,3)4/h6-7,12-15,17H,5,8-11,16H2,1-4H3,(H,30,31,33,34);1H3,(H,2,3,4)
InChi Key
NCJPFQPEVDHJAZ-UHFFFAOYSA-N

Structure of LY-2835219 biochemical

LY-2835219 Biochemical – Cat# MBS846186

Other Notes

Small volumes of LY-2835219 biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for LY-2835219 purchase

MBS846186 is a biochemical targeting LY-2835219.
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