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Entrectinib ((Z)-N- (5- (3)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS846461

Entrectinib is an inhibitor of TrkA (IC50 = 1.7 nM); TrkB (IC50 = 0.1 nM); and TrkC (IC50 = 0.1 nM); as well as C-ros oncogene 1 (ROS1; IC50 = 0.2 nM) and anaplastic lymphoma kinase (ALK; IC50 = 1.6 nM). Entrectinib blocks proliferation of ALK-dependent… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
Entrectinib, Biochemical
Full Product Name
Entrectinib
Product Synonym Names
(Z)-N- (5- (3; 5-difluorobenzyl)-1H-indazol-3 (2H)-ylidene)-4- (4-methylpiperazin-1-yl)-2- ( (tetrahydro-2H-pyran-4-yl) amino) benzamide
Form/Format
White to off-white solid
Purity/Purification
>=97% by HPLC
Preparation and Storage
Store at -20 degree C for 36 months.
Protect from air and light.
Molecular Weight
560.64
Salt Form
No
CAS Number
1108743-60-7
Cell-Permeable
Yes
Reconstitution
DMSO
SMILES
N1CCN(CC1)C2=CC(=C(C=C2)C(=O)NC3=NNC4=C3C=C(C=C4)CC5=CC(=CC(=C5)F)F)NC6CCOCC6
InChi
InChI=1S/C31H34F2N6O2/c1-38-8-10-39(11-9-38)25-3-4-26(29(19-25)34-24-6-12-41-13-7-24)31(40)35-30-27-17-20(2-5-28(27)36-37-30)14-21-15-22(32)18-23(33)16-21/h2-5,15-19,24,34H,6-14H2,1H3,(H2,35,36,37,40)
InChi Key
HAYYBYPASCDWEQ-UHFFFAOYSA-N

Structure of Entrectinib biochemical

Entrectinib (Z)-N- (5- (3 Biochemical – Cat# MBS846461

Other Notes

Small volumes of Entrectinib biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Entrectinib purchase

MBS846461 is a biochemical targeting Entrectinib.
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