Frizzled-7/FZD7 (FZD7) Human Cellexp Recombinant Protein

Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 putative transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif. FZD7 gene expression may downregulate APC function and enhance beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas. [provided by RefSeq, Jul 2008]

FZD7: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Belongs to the G-protein coupled receptor Fz/Smo family.

Protein type: GPCR, Fz/Smo family; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR

Chromosomal Location of Human Ortholog: 2q33.1

Cellular Component: integral to membrane; plasma membrane; recycling endosome membrane

Molecular Function: frizzled binding; G-protein coupled receptor activity; PDZ domain binding; phosphatidylinositol-4,5-bisphosphate binding; protein binding; Wnt receptor activity; Wnt-protein binding

Biological Process: negative regulation of ectodermal cell fate specification; neuron differentiation; positive regulation of epithelial cell proliferation involved in wound healing; positive regulation of JNK cascade; positive regulation of phosphorylation; positive regulation of transcription, DNA-dependent; regulation of transcription, DNA-dependent; stem cell maintenance; Wnt receptor signaling pathway through beta-catenin; Wnt receptor signaling pathway, planar cell polarity pathway