Biotinylated Pd-1/PDCD1 (PDCD1) Active Protein

Programmed death protein 1 (PD-1) is also known as CD279 and PDCD1; is a type I membrane protein and is a member of the extended CD28/CTLA-4 family of T cell regulators. PDCD1 is expressed on the surface of activated T cells; B cells; macrophages; myeloid cells and a subset of thymocytes. PD-1 has two ligands; PD-L1 and PD-L2; which are members of the B7 family. PD-L1 is expressed on almost all murine tumor cell lines; including PA1 myeloma; P815 mastocytoma; and B16 melanoma upon treatment with IFN-gamma. PD-L2 expression is more restricted and is expressed mainly by DCs and a few tumor lines. PD1 inhibits the T-cell proliferation and production of related cytokines including IL-1; IL-4; IL-10 and IFN-gamma by suppressing the activation and transduction of PI3K/AKT pathway. In addition; coligation of PD1 inhibits BCR-mediating signal by dephosphorylating key signal transducer. In vitro; treatment of anti-CD3 stimulated T cells with PD-L1-Ig results in reduced T cell proliferation and IFN-gamma secretion. Monoclonal antibodies targeting PD-1 that boost the immune system are being developed for the treatment of cancer. This protein is suitable for use in protein studies such as protein structure analysis and protein-protein interactions. It can also be used as an immunogen; as a protein standard; or in cell biology research applications.

Small volumes of PDCD1 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS846966 is an active protein targeting PDCD1. Also known as Biotinylated PD-1/PDCD1; Human Recombinant. Host: E Coli
Source: Human.