B7-1/CD80 (CD80) Human Cellexp Active Protein

B7-1 and B7-2; together with their receptors CD28 and CTLA-4; constitute one of the dominant co-stimulatory pathways that regulate T- and B-cell responses. Although both CTLA-4 and CD28 can bind to the same ligands; CTLA-4 binds to B7-1 and B7-2 with a 20- 100 fold higher affinity than CD28 and is involved in the down-regulation of the immune response. B-lymphocyte activation antigen B7-1 (referred to as B7) also known as cluster of Differentiation 80 (CD80); is a member of cell surface immunoglobulin superfamily and is expressed on activated B cells; activated T cells; macrophages and dendritic cells. It is the ligand for two different proteins on the T cell surface: CD28 (for autoregulation and intercellular association) and CTLA- 4 (for attenuation of regulation and cellular disassociation). CD80 works in tandem with CD86 to prime T cells. CD80 plays a role in induction of innate immune responses by activating NF-kappaB-signaling pathway in macrophages. CD80 is thus regarded as promising therapeutic targets for autoimmune diseases and various carcinomas.

Small volumes of CD80 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS847003 is an active protein targeting CD80. Also known as Human CellExp B7-1/CD80; mouse recombinant. Host: HEK 293 cells
Source: Mouse.