Human Cellexp CD47 Recombinant Protein – Cat# MBS847004

CD47 Human Cellexp Recombinant Protein

Name: CD47 Recombinant Protein; Human Cellexp; MyBioSource
Brand: MyBioSource
SKU: MBS847004
Price: 210 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS847004

Leukocyte surface antigen CD47 is also known as Antigenic surface determinant protein OA3; Integrin-associated protein (IAP) and Protein MER6. CD47 contains 1 Ig-like V-type (immunoglobulin-like) domain. CD47 is very broadly distributed on normal adult… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

CD47, Recombinant Protein

Full Product Name

Human CellExp CD47; rat recombinant

Product Gene Name

CD47 recombinant protein

Product Synonym Names

CD47; MER6; IAP; OA3

Host

HEK 293 cells
Source: Rat

Form/Format

Lyophilized from 0.22 mum filtered solution in PBS; pH 7.4. Generally Mannitol or Trehalose is added as a protectant before lyophilization.

Purity/Purification

>95%

Preparation and Storage

Store at -20 degree C for 12 months.
Centrifuge the vial prior to opening.

Molecular Weight

40.4 kDa

3D Structure

ModBase 3D Structure for P97829

Endotoxin Level

< 1 EU/mug

Reconstitution

Reconstitute in sterile deionized water to a concentration of 50 mug/ml.

Applications Tested/Suitable for CD47 recombinant protein

SDS-PAGE

Other Notes

Small volumes of CD47 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CD47 purchase

MBS847004 is a recombinant protein targeting CD47. Also known as Human CellExp CD47; rat recombinant. Host: HEK 293 cells
Source: Rat.

Additional Details

NCBI/Uniprot data below describe general gene information for CD47. It may not necessarily be applicable to this product.

NCBI GI #

9506469

NCBI GeneID

29364

NCBI Accession #

NP_062068.1

UniProt Primary Accession #

P97829

UniProt Secondary Accession #

O35294

UniProt Related Accession #

P97829

GenBank Nucleotide #

NM_019195.2

NCBI Official Full Name

leukocyte surface antigen CD47

NCBI Official Synonym Full Names

Cd47 molecule

NCBI Official Symbol

Cd47

NCBI Official Synonym Symbols

Itgp

UniProt Protein Name

Leukocyte surface antigen CD47

UniProt Synonym Protein Names

Integrin-associated protein; IAP; CD_antigen: CD47

Protein Family

Leukocyte surface antigen

UniProt Gene Name

Cd47

UniProt Synonym Gene Names

IAP

NCBI Protein Information

leukocyte surface antigen CD47

NCBI Summary for CD47

protein that may be involved in regulating renal cell growth; overexpression is associated with Fe-NTA-induced renal damage and tumor progression and metastasis [RGD, Feb 2006]

UniProt Comments for CD47

CD47: Has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins. Plays an important role in memory formation and synaptic plasticity in the hippocampus. Receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation. May play a role in membrane transport and/or integrin dependent signal transduction. May prevent premature elimination of red blood cells. May be involved in membrane permeability changes induced following virus infection. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 11q21

Cellular Component: integral to plasma membrane

Biological Process: cell migration; opsonization; positive regulation of cell proliferation; positive regulation of cell-cell adhesion; positive regulation of inflammatory response; positive regulation of phagocytosis; positive regulation of T cell activation; response to bacterium

Research Articles on CD47

1. down-regulation of CD47 exerts a protective effect against myocardial I/R injury, which may be attributable to attenuation of oxidative stress via activation of the eNOS/nitric oxide signaling pathway.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with CD47 recombinant protein

Products by Pathway	Pathway Diagram
Cell Junction Organization Pathway antibodies	Cell Junction Organization Pathway Diagram
Cell Surface Interactions At The Vascular Wall Pathway antibodies	Cell Surface Interactions At The Vascular Wall Pathway Diagram
ECM-receptor Interaction Pathway antibodies	ECM-receptor Interaction Pathway Diagram
ECM-receptor Interaction Pathway antibodies	ECM-receptor Interaction Pathway Diagram
Hemostasis Pathway antibodies	Hemostasis Pathway Diagram
Interactions Of The Immunoglobulin Superfamily (IgSF) Member Proteins Pathway antibodies	Interactions Of The Immunoglobulin Superfamily (IgSF) Member Proteins Pathway Diagram
Signal Regulatory Protein (SIRP) Family Interactions Pathway antibodies	Signal Regulatory Protein (SIRP) Family Interactions Pathway Diagram

Diseases associated with CD47 recombinant protein

Disease Name	Pubmed Publications
Neoplasms Antibodies	>68 publications with CD47 and Neoplasms
Inflammation Antibodies	>51 publications with CD47 and Inflammation
Hematologic Diseases Antibodies	>48 publications with CD47 and Hematologic Diseases
Autoimmune Diseases Antibodies	>31 publications with CD47 and Autoimmune Diseases
Leukemia Antibodies	>29 publications with CD47 and Leukemia
Genetic Diseases, Inborn Antibodies	>24 publications with CD47 and Genetic Diseases, Inborn
Carcinoma Antibodies	>15 publications with CD47 and Carcinoma
Neuroectodermal Tumors Antibodies	>14 publications with CD47 and Neuroectodermal Tumors
Melanoma Antibodies	>13 publications with CD47 and Melanoma
Leukemia, Myeloid Antibodies	>12 publications with CD47 and Leukemia, Myeloid

Organs/Tissues associated with CD47 recombinant protein

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>36 publications with CD47 and Brain
Spleen Antibodies	>20 publications with CD47 and Spleen
Lung Antibodies	>16 publications with CD47 and Lung
Kidney Antibodies	>12 publications with CD47 and Kidney
Liver Antibodies	>11 publications with CD47 and Liver
Ovary Antibodies	>10 publications with CD47 and Ovary
Embryonic Tissue Antibodies	>8 publications with CD47 and Embryonic Tissue
Thymus Antibodies	>7 publications with CD47 and Thymus
Connective Tissue Antibodies	>7 publications with CD47 and Connective Tissue
Prostate Antibodies	>5 publications with CD47 and Prostate