Human Cellexp CTLA4 Active Protein – Cat# MBS847009

CTLA-4/CD152 (CTLA4) Human Cellexp Active Protein

Name: CTLA4 Active Protein; CTLA-4/CD152; Human Cellexp; MyBioSource
Brand: MyBioSource
SKU: MBS847009
Price: 210 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS847009

CTLA-4 (Cytotoxic T-Lymphocyte Antigen 4) is also known as CD152 (Cluster of differentiation 152); is a protein receptor that downregulates the immune system. CTLA4 is a member of the immunoglobulin superfamily; which is expressed on the surface of Helper T… More details

DISCONTINUED
Click here to view our similar product(s) OR click here to contact our technical support team for suitable replacement.

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

CTLA-4/CD152 (CTLA4), Active Protein

Full Product Name

Human CellExp CTLA-4/CD152; mouse recombinant

Product Gene Name

CTLA4 active protein

Product Synonym Gene Name

CD152

Product Synonym Names

CTLA4; CD152; CELIAC3; GRD4; GSE; ICOS; IDDM12

Host

HEK 293 cells
Source: Mouse

Form/Format

Lyophilized from 0.22 mum filtered solution in PBS; pH 7.4. Generally Mannitol or Trehalose is added as a protectant before lyophilization.

Purity/Purification

>95%

Preparation and Storage

Store at -20 degree C for 12 months.
Centrifuge the vial prior to opening.

Molecular Weight

41.1 kDa

3D Structure

ModBase 3D Structure for P09793

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Endotoxin Level

< 1 EU/mug

Biological Activity

Immobilized Mouse B7-1 and B7-2, Fc Tag at 0.2 mug/mL (100 mu L/well) can bind Mouse CTLA-4, mouse IgG2a Fc tag with a linear range of 0.1-3 ng/mL and 0.4-3 ng/mL respectively.

Binding Capacity

Immobilized Mouse B7-1 and B7-2; Fc Tag at 0.2 mug/mL (100 mu L/well) can bind Mouse CTLA-4; mouse IgG2a Fc tag with a linear range of 0.1-3 ng/mL and 0.4-3 ng/mL respectively.

Reconstitution

Reconstitute in sterile deionized water to a concentration of 50 mug/ml.

Applications Tested/Suitable for CTLA4 active protein

SDS-PAGE, Functional Assay

Other Notes

Small volumes of CTLA4 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CTLA4 purchase

MBS847009 is an active protein targeting CTLA4. Also known as Human CellExp CTLA-4/CD152; mouse recombinant. Host: HEK 293 cells
Source: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for CTLA4. It may not necessarily be applicable to this product.

NCBI GI #

31981847

NCBI GeneID

12477

NCBI Accession #

NP_033973.2

UniProt Primary Accession #

P09793

UniProt Secondary Accession #

Q9QZZ7

UniProt Related Accession #

P09793

GenBank Nucleotide #

NM_009843.4

NCBI Official Full Name

cytotoxic T-lymphocyte protein 4 isoform 1

NCBI Official Synonym Full Names

cytotoxic T-lymphocyte-associated protein 4

NCBI Official Symbol

Ctla4

NCBI Official Synonym Symbols

Cd152; Ly-56; Ctla-4

UniProt Protein Name

Cytotoxic T-lymphocyte protein 4

UniProt Synonym Protein Names

Cytotoxic T-lymphocyte-associated antigen 4; CTLA-4; CD_antigen: CD152

Protein Family

Cytotoxic T-lymphocyte protein

UniProt Gene Name

Ctla4

UniProt Synonym Gene Names

Cd152; CTLA-4

NCBI Protein Information

cytotoxic T-lymphocyte protein 4

NCBI Summary for CTLA4

This gene is a member of the immunoglobulin superfamily, and encodes a protein that functions as a negative regulator of T-cell responses. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2013]

UniProt Comments for CTLA4

Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28 ().

Research Articles on CTLA4

1. this study shows that miR-155 is modulated by a major dust mite allergen, Dermatophagoides farinae (Df1), and increases CD4+ T cell proliferation through the downregulation of cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) expression

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with CTLA4 active protein

Reference Product	PubMed Publications
Cd80 active protein	>868 publications with CTLA4 and Cd80
Cd86 active protein	>562 publications with CTLA4 and Cd86
Src active protein	>26 publications with CTLA4 and Src
Icosl active protein	>17 publications with CTLA4 and Icosl
Lck active protein	>16 publications with CTLA4 and Lck
Ptpn11 active protein	>12 publications with CTLA4 and Ptpn11
Fyn active protein	>6 publications with CTLA4 and Fyn
Lyn active protein	>4 publications with CTLA4 and Lyn

Pathways associated with CTLA4 active protein

Products by Pathway	Pathway Diagram
Adaptive Immune System Pathway antibodies	Adaptive Immune System Pathway Diagram
Autoimmune Thyroid Disease Pathway antibodies	Autoimmune Thyroid Disease Pathway Diagram
Autoimmune Thyroid Disease Pathway antibodies	Autoimmune Thyroid Disease Pathway Diagram
CTLA4 Inhibitory Signaling Pathway antibodies	CTLA4 Inhibitory Signaling Pathway Diagram
Cell Adhesion Molecules (CAMs) Pathway antibodies	Cell Adhesion Molecules (CAMs) Pathway Diagram
Cell Adhesion Molecules (CAMs) Pathway antibodies	Cell Adhesion Molecules (CAMs) Pathway Diagram
Costimulation By The CD28 Family Pathway antibodies	Costimulation By The CD28 Family Pathway Diagram
Immune System Pathway antibodies	Immune System Pathway Diagram
Rheumatoid Arthritis Pathway antibodies	Rheumatoid Arthritis Pathway Diagram
Rheumatoid Arthritis Pathway antibodies	Rheumatoid Arthritis Pathway Diagram

Diseases associated with CTLA4 active protein

Disease Name	Pubmed Publications
Melanoma Antibodies	>741 publications with CTLA4 and Melanoma
Inflammation Antibodies	>438 publications with CTLA4 and Inflammation
Necrosis Antibodies	>412 publications with CTLA4 and Necrosis
Carcinoma Antibodies	>269 publications with CTLA4 and Carcinoma
Arthritis, Rheumatoid Antibodies	>254 publications with CTLA4 and Arthritis, Rheumatoid
Graves Disease Antibodies	>191 publications with CTLA4 and Graves Disease
Liver Diseases Antibodies	>182 publications with CTLA4 and Liver Diseases
Neoplasms, Experimental Antibodies	>178 publications with CTLA4 and Neoplasms, Experimental
Lung Neoplasms Antibodies	>127 publications with CTLA4 and Lung Neoplasms
Neoplasm Metastasis Antibodies	>118 publications with CTLA4 and Neoplasm Metastasis

Organs/Tissues associated with CTLA4 active protein

Organ/Tissue Name	Pubmed Publications
Spleen Antibodies	>289 publications with CTLA4 and Spleen
Mixed Antibodies	>248 publications with CTLA4 and Mixed
Bone Marrow Antibodies	>188 publications with CTLA4 and Bone Marrow
Thymus Antibodies	>137 publications with CTLA4 and Thymus
Mammary Gland Antibodies	>1 publications with CTLA4 and Mammary Gland