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Pd-L2/B7-Dc (PD-L2) Human Cellexp Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS847015

Programmed cell death 1 ligand 2 (PD-L2 or PDCD1 ligand 2) is also known as Butyrophilin B7-DC; CD antigen CD273; which belongs to the immunoglobulin superfamily or BTN/MOG family. The expression of PD-L2 is up-regulated by IFNG/IFN-gamma stimulation in… More details

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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
PD-L2/B7-DC, Recombinant Protein
Full Product Name
Human CellExp PD-L2/B7-DC; mouse recombinant
Product Gene Name
PD-L2 recombinant protein
Product Synonym Gene Name
B7-DC; Pdcd1lg2
Product Synonym Names
PDL2; PD-L2; Butyrophilin B7-DC; CD273; PDCD1 ligand 2; PDCD1L2; PDCD1LG2
Host
HEK 293 cells
Source: Mouse
Form/Format
Lyophilized from 0.22 mum filtered solution in PBS; pH 7.4. Generally 5-8% Mannitol or trehalose is added as a protectant before lyophilization.
Purity/Purification
>=95%
Preparation and Storage
Store at -20 degree C for 12 months.
Centrifuge the vial prior to opening.
Molecular Weight
49.6 kDa
3D Structure
ModBase 3D Structure for Q9WUL5
Endotoxin Level
< 0.1 EU/mug
Reconstitution
Reconstitute in sterile deionized water to a concentration of 50 mug/ml.
Applications Tested/Suitable for PD-L2 recombinant protein
SDS-PAGE

Other Notes

Small volumes of PD-L2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PD-L2 purchase

MBS847015 is a recombinant protein targeting PD-L2. Also known as Human CellExp PD-L2/B7-DC; mouse recombinant. Host: HEK 293 cells
Source: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for PD-L2. It may not necessarily be applicable to this product.

NCBI GI #
10946740
NCBI GeneID
58205
NCBI Accession #
NP_067371.1
UniProt Primary Accession #
Q9WUL5
UniProt Related Accession #
Q9WUL5
GenBank Nucleotide #
NM_021396.2
NCBI Official Full Name
programmed cell death 1 ligand 2
NCBI Official Synonym Full Names
programmed cell death 1 ligand 2
NCBI Official Symbol
Pdcd1lg2
NCBI Official Synonym Symbols
Btdc; B7-DC; PD-L2; F730015O22Rik
UniProt Protein Name
Programmed cell death 1 ligand 2
UniProt Synonym Protein Names
Butyrophilin B7-DC; B7-DC; CD_antigen: CD273
UniProt Gene Name
Pdcd1lg2
UniProt Synonym Gene Names
B7dc; Btdc; Cd273; Pdl2; PD-1 ligand 2; PD-L2; PDCD1 ligand 2; Programmed death ligand 2; B7-DC
NCBI Protein Information
programmed cell death 1 ligand 2

UniProt Comments for PD-L2

PDCD1LG2: Involved in the costimulatory signal, essential for T- cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production. Belongs to the immunoglobulin superfamily. BTN/MOG family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 19|19 C1

Molecular Function: protein binding

Biological Process: negative regulation of activated T cell proliferation; negative regulation of interferon-gamma production; negative regulation of interleukin-10 production; negative regulation of T cell proliferation; positive regulation of T cell proliferation
Show more

Research Articles on PD-L2

1. injection of gene knockdown-dendritic cells induces intra-tumor T cell infiltration and release of inflammatory cytokines

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with PD-L2 recombinant protein

 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Costimulation By The CD28 Family Pathway antibodies  Costimulation By The CD28 Family Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 PD-1 Signaling Pathway antibodies  PD-1 Signaling Pathway Diagram

Diseases associated with PD-L2 recombinant protein

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >28 publications with PD-L2 and Inflammation
 Necrosis Antibodies  >16 publications with PD-L2 and Necrosis
 Carcinoma Antibodies  >13 publications with PD-L2 and Carcinoma
 Nervous System Diseases Antibodies  >12 publications with PD-L2 and Nervous System Diseases
 Lung Diseases Antibodies  >12 publications with PD-L2 and Lung Diseases
 Adenocarcinoma Antibodies  >8 publications with PD-L2 and Adenocarcinoma
 Cardiovascular Diseases Antibodies  >7 publications with PD-L2 and Cardiovascular Diseases
 Liver Neoplasms Antibodies  >5 publications with PD-L2 and Liver Neoplasms
 Kidney Diseases Antibodies  >4 publications with PD-L2 and Kidney Diseases
 Lung Neoplasms Antibodies  >4 publications with PD-L2 and Lung Neoplasms

Organs/Tissues associated with PD-L2 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >9 publications with PD-L2 and Brain
 Skin Antibodies  >5 publications with PD-L2 and Skin
 Thymus Antibodies  >2 publications with PD-L2 and Thymus
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