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ICOSLG /B7-H2 /CD275 (ICOSLG) Active Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS847034

Mouse CD275 (B7-H2) is a member of the growing B7 family of immune costimulatory proteins. CD275 has been identified as the ligand for ICOS; a member of the CD28 family of co-stimulatory receptors. Mouse CD275 is expressed on resting B cells and at low levels… More details

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Technical Datasheet View PDF
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Product Overview

Product Name
ICOSLG /B7-H2 /CD275, Active Protein
Full Product Name
ICOSLG /B7-H2 /CD275; mouse recombinant
Product Gene Name
ICOSLG active protein
Product Synonym Gene Name
B7-H2; CD275
Product Synonym Names
B7-H2; ICOS Ligand; B7-like Protein Gl50; B7RP-1
Host
CHO cells
Source: Mouse
Form/Format
Lyophilized from 0.2 mum-filtered solution in PBS
Purity/Purification
>=95%
Preparation and Storage
Store at -20 degree C for 12 months.
Centrifuge the vial prior to opening.
Molecular Weight
38,914 Da
3D Structure
ModBase 3D Structure for Q9JHJ8
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Endotoxin Level
< 0.06 EU/mug
Biological Activity
Immobilized human ICOS at 1mug/ml (100mul/well) can bind biotinylated B7-H2 (mouse), Fc (mouse) (rec.) (non-lytic) with a linear range of 0.1-1.0mug/ml.
Binding Capacity
Immobilized human ICOS at 1mug/ml (100mul/well) can bind biotinylated B7-H2 (mouse); Fc (mouse) (rec.) (non-lytic) with a linear range of 0.1-1.0mug/ml.
Reconstitution
Reconstitute at 100 mug/ml in sterile PBS
Applications Tested/Suitable for ICOSLG active protein
SDS-PAGE, Functional Assay

Other Notes

Small volumes of ICOSLG active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ICOSLG purchase

MBS847034 is an active protein targeting ICOSLG. Also known as ICOSLG /B7-H2 /CD275; mouse recombinant. Host: CHO cells
Source: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for ICOSLG. It may not necessarily be applicable to this product.

NCBI GI #
7657220
NCBI GeneID
50723
NCBI Accession #
NP_056605.1
UniProt Primary Accession #
Q9JHJ8
UniProt Related Accession #
Q9JHJ8
GenBank Nucleotide #
NM_015790.3
NCBI Official Full Name
ICOS ligand
NCBI Official Synonym Full Names
icos ligand
NCBI Official Symbol
Icosl
NCBI Official Synonym Symbols
B7h; GI50; GL50; B7-H2; LICOS; B7RP-1; GL50-B; ICOS-L; Icoslg; Ly115l; AU044799; BG071784; mKIAA0653
UniProt Protein Name
ICOS ligand
UniProt Synonym Protein Names
B7 homolog 2; B7-H2; B7-like protein Gl50; B7-related protein 1; B7RP-1; LICOS; CD_antigen: CD275
Protein Family
ICOS ligand
UniProt Gene Name
Icoslg
UniProt Synonym Gene Names
B7h2; B7rp1; Icosl; B7-H2; B7RP-1
NCBI Protein Information
ICOS ligand

UniProt Comments for ICOSLG

ICOSLG: Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co- stimulating memory T-cell function. Belongs to the immunoglobulin superfamily. BTN/MOG family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 10|10 C1

Cellular Component: external side of plasma membrane; integral to plasma membrane

Molecular Function: protein binding; receptor binding

Biological Process: positive regulation of activated T cell proliferation; positive regulation of interleukin-4 biosynthetic process
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Research Articles on ICOSLG

1. The expression of ICOSL in the cornea and the ICOS-mediated induction of Foxp3+ CD4+ regulatory T cells may contribute to successful corneal allograft survival.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with ICOSLG active protein

 Reference Product  PubMed Publications
 Icos active protein  >142 publications with ICOSLG and Icos
 Cd28 active protein  >55 publications with ICOSLG and Cd28
 Cd40 active protein  >31 publications with ICOSLG and Cd40
 Ctla4 active protein  >25 publications with ICOSLG and Ctla4
 Casp3 active protein  >2 publications with ICOSLG and Casp3
 Cxcl12 active protein  >1 publications with ICOSLG and Cxcl12

Pathways associated with ICOSLG active protein

 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Costimulation By The CD28 Family Pathway antibodies  Costimulation By The CD28 Family Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Intestinal Immune Network For IgA Production Pathway antibodies  Intestinal Immune Network For IgA Production Pathway Diagram
 Intestinal Immune Network For IgA Production Pathway antibodies  Intestinal Immune Network For IgA Production Pathway Diagram

Diseases associated with ICOSLG active protein

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >28 publications with ICOSLG and Inflammation
 Necrosis Antibodies  >23 publications with ICOSLG and Necrosis
 Disease Models, Animal Antibodies  >22 publications with ICOSLG and Disease Models, Animal
 Lung Diseases Antibodies  >12 publications with ICOSLG and Lung Diseases
 Cardiovascular Diseases Antibodies  >10 publications with ICOSLG and Cardiovascular Diseases
 Fibrosis Antibodies  >6 publications with ICOSLG and Fibrosis
 Kidney Diseases Antibodies  >5 publications with ICOSLG and Kidney Diseases
 Liver Diseases Antibodies  >5 publications with ICOSLG and Liver Diseases
 Demyelinating Diseases Antibodies  >5 publications with ICOSLG and Demyelinating Diseases
 Immunoproliferative Disorders Antibodies  >4 publications with ICOSLG and Immunoproliferative Disorders

Organs/Tissues associated with ICOSLG active protein

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >155 publications with ICOSLG and Blood
 Spleen Antibodies  >17 publications with ICOSLG and Spleen
 Bone Marrow Antibodies  >12 publications with ICOSLG and Bone Marrow
 Skin Antibodies  >10 publications with ICOSLG and Skin
 Kidney Antibodies  >7 publications with ICOSLG and Kidney
 Brain Antibodies  >5 publications with ICOSLG and Brain
 Embryonic Tissue Antibodies  >3 publications with ICOSLG and Embryonic Tissue
 Intestine Antibodies  >2 publications with ICOSLG and Intestine
 Ovary Antibodies  >2 publications with ICOSLG and Ovary
 Thymus Antibodies  >1 publications with ICOSLG and Thymus
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