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TIM-4 Active Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS847036

The TIM (T cell/transmembrane; immunoglobulin and mucin) family plays a critical role in regulating immune responses; including allergy; asthma; transplant tolerance; autoimmunity and the response to viral infections. The unique structure of TIM… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
TIM-4, Active Protein
Full Product Name
TIM-4; human recombinant
Product Gene Name
TIM-4 active protein
Product Synonym Gene Name
TIMD4
Product Synonym Names
TIM4; TIMD4; T Cell Immunoglobulin and Mucin Domain-containing Protein 4; T Cell Membrane Protein 4
Host
CHO cells
Source: Human
Form/Format
Lyophilized from 0.2 mum-filtered solution in PBS
Purity/Purification
>=98%
Preparation and Storage
Store at -20 degree C for 12 months.
Centrifuge the vial prior to opening.
Molecular Weight
38,536 Da
OMIM
AK301337 mRNA
3D Structure
ModBase 3D Structure for Q96H15
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Endotoxin Level
< 0.06 EU/mug
Biological Activity
Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated human T cells.
Reconstitution
Reconstitute with 100 ul sterile water.
Applications Tested/Suitable for TIM-4 active protein
SDS-PAGE

Other Notes

Small volumes of TIM-4 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TIM-4 purchase

MBS847036 is an active protein targeting TIM-4. Also known as TIM-4; human recombinant. Host: CHO cells
Source: Human.

Additional Details

NCBI/Uniprot data below describe general gene information for TIM-4. It may not necessarily be applicable to this product.

NCBI GI #
226498466
NCBI GeneID
91937
NCBI Accession #
NP_001140198.1
UniProt Primary Accession #
Q96H15
UniProt Secondary Accession #
B5MCL9
UniProt Related Accession #
Q96H15
GenBank Nucleotide #
NM_001146726.1
NCBI Official Full Name
T-cell immunoglobulin and mucin domain-containing protein 4 isoform 2
NCBI Official Synonym Full Names
T-cell immunoglobulin and mucin domain containing 4
NCBI Official Symbol
TIMD4
NCBI Official Synonym Symbols
TIM4; SMUCKLER
UniProt Protein Name
T-cell immunoglobulin and mucin domain-containing protein 4
UniProt Synonym Protein Names
T-cell immunoglobulin mucin receptor 4; TIM-4; T-cell membrane protein 4
Protein Family
T-cell immunoglobulin and mucin domain-containing protein
UniProt Gene Name
TIMD4
UniProt Synonym Gene Names
TIM4; TIMD-4; TIM-4
NCBI Protein Information
T-cell immunoglobulin and mucin domain-containing protein 4

UniProt Comments for TIM-4

TIM-4: Phosphatidylserine receptor that enhances the engulfment of apoptotic cells. Involved in regulating T-cell proliferation and lymphotoxin signaling. Ligand for HAVCR1/TIMD1. Belongs to the immunoglobulin superfamily. TIM family.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 5q33.3
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Research Articles on TIM-4

1. analysis of the molecular characteristics of both mTIM-4 and hTIM-4 provides a better understanding of the regions of the TIM-4 IgV domain critical for Ebola virus entry

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with TIM-4 active protein

 Disease Name  Pubmed Publications
 Respiratory Hypersensitivity Antibodies  >7 publications with TIM-4 and Respiratory Hypersensitivity
 Lung Diseases Antibodies  >6 publications with TIM-4 and Lung Diseases
 Inflammation Antibodies  >4 publications with TIM-4 and Inflammation
 Necrosis Antibodies  >3 publications with TIM-4 and Necrosis
 Fetal Death Antibodies  >1 publications with TIM-4 and Fetal Death

Organs/Tissues associated with TIM-4 active protein

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >4 publications with TIM-4 and Liver
 Spleen Antibodies  >2 publications with TIM-4 and Spleen
 Kidney Antibodies  >2 publications with TIM-4 and Kidney
 Lymph Node Antibodies  >1 publications with TIM-4 and Lymph Node
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