Human Cellexp TNFSF18 Active Protein – Cat# MBS847054

GITR Ligand/TNFSF18 (TNFSF18) Human Cellexp Active Protein

Name: TNFSF18 Active Protein; GITR Ligand/TNFSF18; Human Cellexp; MyBioSource
Brand: MyBioSource
SKU: MBS847054
Price: 220 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS847054

Tumor necrosis factor ligand superfamily member 18 (TNFSF18) is also known as Glucocorticoid- induced TNF-related ligand (GITRL or GITR Ligand); Activation- inducible TNF- related ligand (AITRL); which belongs to the tumor necrosis factor family. TNFSF18 is… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

GITR Ligand/TNFSF18, Active Protein

Full Product Name

Human CellExp GITR Ligand/TNFSF18 Fc Tag; Mouse recombinant

Product Gene Name

TNFSF18 active protein

Product Synonym Names

TNFSF18; AITRL; TL6; hGITRL; GITR Ligand

Host

HEK 293 cells
Source: Mouse

Form/Format

Lyophilized from 0.22 mum filtered solution in PBS; pH 7.4. Normally Trehalose is added as protectant before lyophilization.

Purity/Purification

> 95%

Preparation and Storage

Store at -20 degree C for 12 months.
Centrifuge the vial prior to opening.

Molecular Weight

41.4 kDa

3D Structure

ModBase 3D Structure for Q7TS55

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Endotoxin Level

< 1.0 EU per/mug

Biological Activity

Immobilized Mouse GITR, His Tag at 10mug/mL (100 muL/well) can bind Mouse GITR Ligand, Fc Tag with a linear range of 0.007-0.256 mug/mL.

Binding Capacity

Immobilized Mouse GITR; His Tag at 10mug/mL (100 muL/well) can bind Mouse GITR Ligand; Fc Tag with a linear range of 0.007-0.256 mug/mL.

Reconstitution

Reconstitute in sterile deionized water to the desired protein concentration.

Applications Tested/Suitable for TNFSF18 active protein

SDS-PAGE, Functional Assay

Other Notes

Small volumes of TNFSF18 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TNFSF18 purchase

MBS847054 is an active protein targeting TNFSF18. Also known as Human CellExp GITR Ligand/TNFSF18 Fc Tag; Mouse recombinant. Host: HEK 293 cells
Source: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for TNFSF18. It may not necessarily be applicable to this product.

NCBI GI #

229892199

NCBI GeneID

240873

NCBI Accession #

NP_899247.3

UniProt Primary Accession #

Q7TS55

UniProt Secondary Accession #

Q7TNY2; Q80YG2

UniProt Related Accession #

Q7TS55

GenBank Nucleotide #

NM_183391.3

NCBI Official Full Name

tumor necrosis factor ligand superfamily member 18

NCBI Official Synonym Full Names

tumor necrosis factor (ligand) superfamily, member 18

NCBI Official Symbol

Tnfsf18

NCBI Official Synonym Symbols

Gitrl; Tnlg2a

UniProt Protein Name

Tumor necrosis factor ligand superfamily member 18

UniProt Synonym Protein Names

GITR ligand; GITRL; Glucocorticoid-induced TNF-related ligand

Protein Family

Tumor necrosis factor ligand superfamily

UniProt Gene Name

Tnfsf18

UniProt Synonym Gene Names

Gitrl; GITRL

NCBI Protein Information

tumor necrosis factor ligand superfamily member 18

UniProt Comments for TNFSF18

TNFSF18: Cytokine that binds to TNFRSF18/AITR/GITR. Regulates T- cell responses. Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B. Belongs to the tumor necrosis factor family.

Protein type: Apoptosis; Cytokine; Membrane protein, integral

Chromosomal Location of Human Ortholog: 1 H2.1|1 69.75 cM

Cellular Component: cell surface

Molecular Function: protein binding; tumor necrosis factor receptor superfamily binding

Biological Process: activation of NF-kappaB transcription factor; cell-cell signaling; interleukin-10 production; interleukin-12 production; positive regulation of cell adhesion; positive regulation of inflammatory response; positive regulation of leukocyte migration; positive regulation of tyrosine phosphorylation of STAT protein; regulation of interferon-gamma production; regulation of interleukin-6 production; regulation of T cell proliferation; regulation of tumor necrosis factor production; T cell proliferation during immune response; tumor necrosis factor-mediated signaling pathway

Research Articles on TNFSF18

1. the upregulation of IFN-beta in DCs induces the up-regulation of coinhibitory molecules B7H1 and GITRL, which cause an impaired activation of naive Ag-specific T cells

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with TNFSF18 active protein

Products by Pathway	Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram

Diseases associated with TNFSF18 active protein

Disease Name	Pubmed Publications
Necrosis Antibodies	>99 publications with TNFSF18 and Necrosis
Inflammation Antibodies	>18 publications with TNFSF18 and Inflammation
Neoplasms, Experimental Antibodies	>9 publications with TNFSF18 and Neoplasms, Experimental
Disease Models, Animal Antibodies	>8 publications with TNFSF18 and Disease Models, Animal
Nervous System Diseases Antibodies	>4 publications with TNFSF18 and Nervous System Diseases
Breast Neoplasms Antibodies	>2 publications with TNFSF18 and Breast Neoplasms
Carcinoma, Hepatocellular Antibodies	>2 publications with TNFSF18 and Carcinoma, Hepatocellular
Liver Neoplasms Antibodies	>2 publications with TNFSF18 and Liver Neoplasms
Atherosclerosis Antibodies	>2 publications with TNFSF18 and Atherosclerosis
Lung Injury Antibodies	>1 publications with TNFSF18 and Lung Injury

Organs/Tissues associated with TNFSF18 active protein

Organ/Tissue Name	Pubmed Publications
Spleen Antibodies	>12 publications with TNFSF18 and Spleen