Human IMPDH2 Active Protein – Cat# MBS847059

Inosine-5'-Monophosphate Dehydrogenase II (IMPDH2) Human Active Protein

Name: IMPDH2 Active Protein; Human; MyBioSource
Brand: MyBioSource
SKU: MBS847059
Price: 320 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS847059

Inosine monophosphate dehydrogenase; IMPDH; (E.C. 1.1.1.205) is the rate-limiting enzyme in de novo guanine nucleotide biosynthesis and it is essential for lymphocyte proliferation. IMPDH oxidizes inosine 5'-monophosphate (IMP) to xanthine 5'-monophosphate… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

Inosine-5'-Monophosphate Dehydrogenase II (IMPDH2), Active Protein

Full Product Name

Human Inosine-5'-Monophosphate Dehydrogenase II; human recombinant

Product Gene Name

IMPDH2 active protein

Product Synonym Names

IMP dehydrogenase type II; IMPDH II; IMPD2; IMPDH

Host

E Coli
Source: Human

Form/Format

Liquid
20 mM Tris; pH 8.0; 150 mM NaCl; 2mM DTT; 2mM EDTA and 20% glycerol

Purity/Purification

> 90%

Preparation and Storage

Store at -20 degree C for 12 months.
Centrifuge the vial prior to opening.

Molecular Weight

57 kDa

OMIM

J04208 mRNA

3D Structure

ModBase 3D Structure for P12268

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Biological Activity

Specific activity is >= 0.1 U/mg in which one unit of enzyme converts 1 mumole of IMP into XMP at 37 degree C and pH 8.

Unit Definition

One unit of enzyme converts 1 mumole of IMP into XMP at 37 degree C and pH 8

Applications Tested/Suitable for IMPDH2 active protein

SDS-PAGE

Other Notes

Small volumes of IMPDH2 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IMPDH2 purchase

MBS847059 is an active protein targeting IMPDH2. Also known as Human Inosine-5'-Monophosphate Dehydrogenase II; human recombinant. Host: E Coli
Source: Human.

Additional Details

NCBI/Uniprot data below describe general gene information for IMPDH2. It may not necessarily be applicable to this product.

NCBI GI #

66933016

NCBI GeneID

3615

NCBI Accession #

NP_000875.2

UniProt Primary Accession #

P12268

UniProt Secondary Accession #

Q6LEF3

UniProt Related Accession #

P12268

GenBank Nucleotide #

NM_000884.2

NCBI Official Full Name

inosine-5'-monophosphate dehydrogenase 2

NCBI Official Synonym Full Names

inosine monophosphate dehydrogenase 2

NCBI Official Symbol

IMPDH2

NCBI Official Synonym Symbols

IMPD2; IMPDH-II

UniProt Protein Name

Inosine-5'-monophosphate dehydrogenase 2

UniProt Synonym Protein Names

IMPDH-II

UniProt Gene Name

IMPDH2

UniProt Synonym Gene Names

IMP dehydrogenase 2; IMPD 2; IMPDH 2

NCBI Protein Information

inosine-5'-monophosphate dehydrogenase 2

NCBI Summary for IMPDH2

This gene encodes the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. The encoded protein catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then converted into guanosine-5'-monophosphate. This gene is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation. [provided by RefSeq, Jul 2008]

UniProt Comments for IMPDH2

Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.

Research Articles on IMPDH2

1. Taking together, these results indicate that natural product myricetin exhibits potent anti-leukemia activity by interfering with purine nucleotides biosynthetic pathway through the suppression of hIMPDH1/2 catalytic activity.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with IMPDH2 active protein

Reference Product	PubMed Publications
HPRT1 active protein	>3 publications with IMPDH2 and HPRT1
ITPA active protein	>2 publications with IMPDH2 and ITPA
GMPR2 active protein	>1 publications with IMPDH2 and GMPR2
GMPS active protein	>1 publications with IMPDH2 and GMPS

Pathways associated with IMPDH2 active protein

Products by Pathway	Pathway Diagram
Drug Metabolism - Other Enzymes Pathway antibodies	Drug Metabolism - Other Enzymes Pathway Diagram
Drug Metabolism - Other Enzymes Pathway antibodies	Drug Metabolism - Other Enzymes Pathway Diagram
Guanine Ribonucleotide Biosynthesis IMP => GDP,GTP Pathway antibodies	Guanine Ribonucleotide Biosynthesis IMP => GDP,GTP Pathway Diagram
Guanine Ribonucleotide Biosynthesis IMP => GDP,GTP Pathway antibodies	Guanine Ribonucleotide Biosynthesis IMP => GDP,GTP Pathway Diagram
Metabolic Pathways antibodies	Metabolic Pathways Diagram
Metabolism Pathway antibodies	Metabolism Pathway Diagram
Metabolism Of Nucleotides Pathway antibodies	Metabolism Of Nucleotides Pathway Diagram
Purine Metabolism Pathway antibodies	Purine Metabolism Pathway Diagram
Purine Metabolism Pathway antibodies	Purine Metabolism Pathway Diagram
Purine Metabolism Pathway antibodies	Purine Metabolism Pathway Diagram

Diseases associated with IMPDH2 active protein

Disease Name	Pubmed Publications
Liver Diseases Antibodies	>5 publications with IMPDH2 and Liver Diseases
Kidney Diseases Antibodies	>4 publications with IMPDH2 and Kidney Diseases
Leukemia Antibodies	>4 publications with IMPDH2 and Leukemia
Inflammation Antibodies	>3 publications with IMPDH2 and Inflammation
Diarrhea Antibodies	>3 publications with IMPDH2 and Diarrhea
Neoplasms, Experimental Antibodies	>2 publications with IMPDH2 and Neoplasms, Experimental
Neoplasm Metastasis Antibodies	>2 publications with IMPDH2 and Neoplasm Metastasis
Prostatic Diseases Antibodies	>2 publications with IMPDH2 and Prostatic Diseases
Uterine Cervical Neoplasms Antibodies	>1 publications with IMPDH2 and Uterine Cervical Neoplasms
Anemia Antibodies	>1 publications with IMPDH2 and Anemia

Organs/Tissues associated with IMPDH2 active protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>24 publications with IMPDH2 and Blood
Kidney Antibodies	>18 publications with IMPDH2 and Kidney
Liver Antibodies	>4 publications with IMPDH2 and Liver
Prostate Antibodies	>4 publications with IMPDH2 and Prostate
Bone Antibodies	>4 publications with IMPDH2 and Bone
Pancreas Antibodies	>2 publications with IMPDH2 and Pancreas
Heart Antibodies	>2 publications with IMPDH2 and Heart
Eye Antibodies	>2 publications with IMPDH2 and Eye
Testis Antibodies	>1 publications with IMPDH2 and Testis
Uterus Antibodies	>1 publications with IMPDH2 and Uterus