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TROP-2/TACSTD2 (TROP-2) Human Cellexp Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS847060

Tumor-associated calcium signal transducer 2 (TACSTD2) is also known as Cell surface glycoprotein Trop-2; Membrane component chromosome 1 surface marker 1 (M1S1); Pancreatic carcinoma marker protein GA733-1; which belongs to the EPCAM family. TACSTD2 contains… More details

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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Product Name
TROP-2/TACSTD2, Recombinant Protein
Full Product Name
Human CellExp TROP-2/TACSTD2; Human recombinant
Product Gene Name
TROP-2 recombinant protein
Product Synonym Gene Name
TACSTD2
Product Synonym Names
TACSTD2; GA733-1; M1S1; TROP2
Host
HEK 293 cells
Source: Human
Form/Format
Lyophilized from 0.22 mum filtered solution in PBS; pH 7.4. Normally Trehalose is added as protectant before lyophilization.
Purity/Purification
> 95%
Preparation and Storage
Store at -20 degree C for 12 months.
Centrifuge the vial prior to opening.
Molecular Weight
28.7 kDa
OMIM
X13425 mRNA
3D Structure
ModBase 3D Structure for P09758
Endotoxin Level
< 1.0 EU per/mug
Reconstitution
Reconstitute in sterile deionized water to the desired protein concentration.
Applications Tested/Suitable for TROP-2 recombinant protein
SDS-PAGE

Testing Data of TROP-2 recombinant protein

Human Cellexp TROP-2 Recombinant Protein – Cat# MBS847060

Other Notes

Small volumes of TROP-2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TROP-2 purchase

MBS847060 is a recombinant protein targeting TROP-2. Also known as Human CellExp TROP-2/TACSTD2; Human recombinant. Host: HEK 293 cells
Source: Human.

Additional Details

NCBI/Uniprot data below describe general gene information for TROP-2. It may not necessarily be applicable to this product.

NCBI GI #
166795236
NCBI GeneID
4070
NCBI Accession #
NP_002344.2
UniProt Primary Accession #
P09758
UniProt Secondary Accession #
Q15658; Q6FG48; Q7Z7Q4; Q96QD2
UniProt Related Accession #
P09758
GenBank Nucleotide #
NM_002353.2
NCBI Official Full Name
tumor-associated calcium signal transducer 2
NCBI Official Synonym Full Names
tumor associated calcium signal transducer 2
NCBI Official Symbol
TACSTD2
NCBI Official Synonym Symbols
EGP1; GP50; M1S1; EGP-1; TROP2; GA7331; GA733-1
UniProt Protein Name
Tumor-associated calcium signal transducer 2
UniProt Synonym Protein Names
Cell surface glycoprotein Trop-2; Membrane component chromosome 1 surface marker 1; Pancreatic carcinoma marker protein GA733-1
UniProt Gene Name
TACSTD2
UniProt Synonym Gene Names
GA733-1; M1S1; TROP2
NCBI Protein Information
tumor-associated calcium signal transducer 2

NCBI Summary for TROP-2

This intronless gene encodes a carcinoma-associated antigen. This antigen is a cell surface receptor that transduces calcium signals. Mutations of this gene have been associated with gelatinous drop-like corneal dystrophy.[provided by RefSeq, Dec 2009]

UniProt Comments for TROP-2

TACSTD2: May function as a growth factor receptor. Defects in TACSTD2 are the cause of gelatinous drop-like corneal dystrophy (GDLD); also known as lattice corneal dystrophy type III. GDLD is an autosomal recessive disorder characterized by grayish corneal amyloid deposits that cause severe visual impairment. Belongs to the EPCAM family.

Protein type: Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 1p32.1

Cellular Component: basal plasma membrane; cytosol; extracellular space; integral to plasma membrane; lateral plasma membrane; membrane; nucleus

Molecular Function: protein binding; receptor activity

Biological Process: cell proliferation; cell surface receptor linked signal transduction; negative regulation of stress fiber formation

Disease: Corneal Dystrophy, Gelatinous Drop-like
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Research Articles on TROP-2

1. TROP-2 membranous staining is a very sensitive and specific marker for the classic and tall cell variants of papillary thyroid carcinoma, and for papillary microcarcinomas , with high overall specificity for papillary thyroid carcinoma

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with TROP-2 recombinant protein

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >43 publications with TROP-2 and Neoplasms
 Adenocarcinoma Antibodies  >10 publications with TROP-2 and Adenocarcinoma
 Neoplasms, Experimental Antibodies  >7 publications with TROP-2 and Neoplasms, Experimental
 Prostatic Diseases Antibodies  >7 publications with TROP-2 and Prostatic Diseases
 Prostatic Neoplasms Antibodies  >7 publications with TROP-2 and Prostatic Neoplasms
 Breast Neoplasms Antibodies  >6 publications with TROP-2 and Breast Neoplasms
 Ovarian Diseases Antibodies  >5 publications with TROP-2 and Ovarian Diseases
 Ovarian Neoplasms Antibodies  >5 publications with TROP-2 and Ovarian Neoplasms
 Lung Neoplasms Antibodies  >4 publications with TROP-2 and Lung Neoplasms
 Lung Diseases Antibodies  >4 publications with TROP-2 and Lung Diseases

Organs/Tissues associated with TROP-2 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Eye Antibodies  >15 publications with TROP-2 and Eye
 Prostate Antibodies  >9 publications with TROP-2 and Prostate
 Liver Antibodies  >6 publications with TROP-2 and Liver
 Lymph Node Antibodies  >6 publications with TROP-2 and Lymph Node
 Lung Antibodies  >5 publications with TROP-2 and Lung
 Skin Antibodies  >2 publications with TROP-2 and Skin
 Uterus Antibodies  >2 publications with TROP-2 and Uterus
 Bone Antibodies  >2 publications with TROP-2 and Bone
 Bone Marrow Antibodies  >1 publications with TROP-2 and Bone Marrow
 Intestine Antibodies  >1 publications with TROP-2 and Intestine
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