Human Cellexp LAG3 Active Protein – Cat# MBS847077

LAG3/CD223 (LAG3) Human Cellexp Active Protein

Name: LAG3 Active Protein; LAG3/CD223; Human Cellexp; MyBioSource
Brand: MyBioSource
SKU: MBS847077
Price: 210 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS847077

Lymphocyte activation gene 3 protein (LAG3) is also known as CD antigen CD223 and protein FDC; which belongs to immunoglobulin (Ig) superfamily and contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. The sequence data; exon/intron… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

LAG3/CD223, Active Protein

Full Product Name

Human CellExp LAG3/CD223; Fc Tag; human recombinant

Product Gene Name

LAG3 active protein

Product Synonym Names

LAG3; CD223; FDC

Host

HEK 293 cells
Source: Human

Form/Format

Lyophilized from 0.22 mum filtered solution in PBS; pH 7.4. Normally Trehalose is added as protectant before lyophilization.

Purity/Purification

> 95%

Preparation and Storage

Store at -20 degree C for 12 months.
Centrifuge the vial prior to opening.

Molecular Weight

72.3 kDa

OMIM

X51985 mRNA

3D Structure

ModBase 3D Structure for P18627

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Endotoxin Level

< 1.0 EU per/mug

Biological Activity

Immobilized Human LAG-3, Fc Tag at 2mug/mL (100 muL/well) can bind Anti-LAG3 MAb, Human IgG1 with a linear range of 0.1-2 ng/mL.

Binding Capacity

Immobilized Human LAG-3; Fc Tag at 2mug/mL (100 muL/well) can bind Anti-LAG3 MAb; Human IgG1 with a linear range of 0.1-2 ng/mL.

Reconstitution

Reconstitute in sterile deionized water to the desired protein concentration.

Applications Tested/Suitable for LAG3 active protein

SDS-PAGE, Functional Assay

Other Notes

Small volumes of LAG3 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for LAG3 purchase

MBS847077 is an active protein targeting LAG3. Also known as Human CellExp LAG3/CD223; Fc Tag; human recombinant. Host: HEK 293 cells
Source: Human.

Additional Details

NCBI/Uniprot data below describe general gene information for LAG3. It may not necessarily be applicable to this product.

NCBI GI #

167614500

NCBI GeneID

3902

NCBI Accession #

NP_002277.4

UniProt Primary Accession #

P18627

UniProt Secondary Accession #

Q7Z643; A8K7T9

UniProt Related Accession #

P18627

GenBank Nucleotide #

NM_002286.5

NCBI Official Full Name

lymphocyte activation gene 3 protein

NCBI Official Synonym Full Names

lymphocyte activating 3

NCBI Official Symbol

LAG3

NCBI Official Synonym Symbols

CD223

UniProt Protein Name

Lymphocyte activation gene 3 protein

UniProt Synonym Protein Names

Protein FDC; CD_antigen: CD223

Protein Family

Lymphocyte activation gene 3 protein

UniProt Gene Name

LAG3

UniProt Synonym Gene Names

FDC; LAG-3

NCBI Protein Information

lymphocyte activation gene 3 protein

NCBI Summary for LAG3

Lymphocyte-activation protein 3 belongs to Ig superfamily and contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. The sequence data, exon/intron organization, and chromosomal localization all indicate a close relationship of LAG3 to CD4. [provided by RefSeq, Jul 2008]

UniProt Comments for LAG3

LAG3: a cell surface receptor involved in lymphocyte activation and neural function. LAG3 expressed on neurons is a receptor that binds extracellular Alpha-synuclein fibrils (PFF) with high affinity, leading to its endocytosis. LAG3 facilitates the neuron-to-neuron spread of PFF and its associated neural toxicity. Binds to HLA class-II antigens. Two isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 12p13.31

Cellular Component: plasma membrane

Molecular Function: antigen binding; MHC class II protein binding

Biological Process: antigen processing and presentation of exogenous peptide antigen via MHC class II

Research Articles on LAG3

1. this review provides the translational rationale for targeting LAG3, as well as historical and current state of clinical trials utilizing LAG3 cancer immunomodulators

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with LAG3 active protein

Reference Product	PubMed Publications
CD4 active protein	>30 publications with LAG3 and CD4
FOXP3 active protein	>19 publications with LAG3 and FOXP3
CTLA4 active protein	>10 publications with LAG3 and CTLA4
PDCD1 active protein	>3 publications with LAG3 and PDCD1
GZMB active protein	>2 publications with LAG3 and GZMB

Diseases associated with LAG3 active protein

Disease Name	Pubmed Publications
Inflammation Antibodies	>10 publications with LAG3 and Inflammation
Disease Models, Animal Antibodies	>7 publications with LAG3 and Disease Models, Animal
Neoplasms, Experimental Antibodies	>3 publications with LAG3 and Neoplasms, Experimental
Lymphoma Antibodies	>3 publications with LAG3 and Lymphoma
Necrosis Antibodies	>3 publications with LAG3 and Necrosis
Immunologic Deficiency Syndromes Antibodies	>2 publications with LAG3 and Immunologic Deficiency Syndromes
Lung Neoplasms Antibodies	>2 publications with LAG3 and Lung Neoplasms
Carcinoma Antibodies	>1 publications with LAG3 and Carcinoma
Heart Diseases Antibodies	>1 publications with LAG3 and Heart Diseases
Carcinoma, Squamous Cell Antibodies	>1 publications with LAG3 and Carcinoma, Squamous Cell

Organs/Tissues associated with LAG3 active protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>48 publications with LAG3 and Blood
Spleen Antibodies	>7 publications with LAG3 and Spleen
Intestine Antibodies	>2 publications with LAG3 and Intestine
Uterus Antibodies	>1 publications with LAG3 and Uterus
Brain Antibodies	>1 publications with LAG3 and Brain