Human Cellexp CD58 Active Protein – Cat# MBS847078

CD58/LFA-3 (CD58) Human Cellexp Active Protein

Name: CD58 Active Protein; CD58/LFA-3; Human Cellexp; MyBioSource
Brand: MyBioSource
SKU: MBS847078
Price: 210 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS847078

CD antigen CD58 is also known as Lymphocyte function-associated antigen 3 (LFA-3). CD58 is a cell adhesion molecule expressed on Antigen Presenting Cells (APC); particularly macrophages. CD58 /LFA3 is ligand of the T-lymphocyte CD2 glycoprotein; which binds… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

CD58/LFA-3, Active Protein

Full Product Name

Human CellExp CD58/LFA-3; Fc Tag; human recombinant

Product Gene Name

CD58 active protein

Product Synonym Gene Name

LFA-3

Product Synonym Names

CD58; LFA3; Ag3

Host

HEK 293 cells
Source: Human

Form/Format

Lyophilized from 0.22 mum filtered solution in PBS; pH 7.4. Normally Trehalose is added as protectant before lyophilization.

Purity/Purification

> 95%

Preparation and Storage

Store at -20 degree C for 12 months.
Centrifuge the vial prior to opening.

Molecular Weight

48.1 kDa

OMIM

Y00636 mRNA

3D Structure

ModBase 3D Structure for P19256

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Endotoxin Level

< 1.0 EU per/mug

Biological Activity

Immobilized Human CD2, His Tag at 2 mug/mL (100 muL/well) can bind Human CD58, Fc Tag with a linear range of 10-156 ng/mL

Binding Capacity

Immobilized Human CD2; His Tag at 2 mug/mL (100 muL/well) can bind Human CD58; Fc Tag with a linear range of 10-156 ng/mL

Reconstitution

Reconstitute in sterile deionized water to the desired protein concentration.

Applications Tested/Suitable for CD58 active protein

SDS-PAGE, Functional Assay

Other Notes

Small volumes of CD58 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CD58 purchase

MBS847078 is an active protein targeting CD58. Also known as Human CellExp CD58/LFA-3; Fc Tag; human recombinant. Host: HEK 293 cells
Source: Human.

Additional Details

NCBI/Uniprot data below describe general gene information for CD58. It may not necessarily be applicable to this product.

NCBI GI #

126225

NCBI GeneID

965

NCBI Accession #

P19256.1

UniProt Primary Accession #

P19256

UniProt Secondary Accession #

Q5U053; Q6IB65; Q96KI9; A8K7G5

UniProt Related Accession #

P19256

NCBI Official Full Name

Lymphocyte function-associated antigen 3

NCBI Official Synonym Full Names

CD58 molecule

NCBI Official Symbol

CD58

NCBI Official Synonym Symbols

ag3; LFA3; LFA-3

UniProt Protein Name

Lymphocyte function-associated antigen 3

UniProt Synonym Protein Names

Surface glycoprotein LFA-3; CD_antigen: CD58

Protein Family

Lymphocyte function-associated antigen

UniProt Gene Name

CD58

UniProt Synonym Gene Names

LFA3; Ag3

NCBI Protein Information

lymphocyte function-associated antigen 3

NCBI Summary for CD58

This gene encodes a member of the immunoglobulin superfamily. The encoded protein is a ligand of the T lymphocyte CD2 protein, and functions in adhesion and activation of T lymphocytes. The protein is localized to the plasma membrane. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2009]

UniProt Comments for CD58

CD58: Ligand of the T-lymphocyte CD2 glycoprotein. This interaction is important in mediating thymocyte interactions with thymic epithelial cells, antigen-independent and -dependent interactions of T-lymphocytes with target cells and antigen- presenting cells and the T-lymphocyte rosetting with erythrocytes. In addition, the LFA-3/CD2 interaction may prime response by both the CD2+ and LFA-3+ cells. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell adhesion; Membrane protein, GPI anchor; Membrane protein, integral

Chromosomal Location of Human Ortholog: 1p13.1

Cellular Component: cell surface; membrane; plasma membrane; secretory granule membrane

Molecular Function: protein binding; receptor binding

Biological Process: heterotypic cell-cell adhesion; leukocyte migration; neutrophil degranulation

Research Articles on CD58

1. data suggest that loss of CD58 is a potential immune escape mechanism of HL tumor cells, especially in clinically aggressive disease

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with CD58 active protein

Reference Product	PubMed Publications
CD2 active protein	>426 publications with CD58 and CD2
ICAM1 active protein	>290 publications with CD58 and ICAM1
CD80 active protein	>178 publications with CD58 and CD80
CD44 active protein	>124 publications with CD58 and CD44
CD40 active protein	>105 publications with CD58 and CD40
IL2 active protein	>7 publications with CD58 and IL2
CD2AP active protein	>1 publications with CD58 and CD2AP

Pathways associated with CD58 active protein

Products by Pathway	Pathway Diagram
Cell Adhesion Molecules (CAMs) Pathway antibodies	Cell Adhesion Molecules (CAMs) Pathway Diagram
Cell Adhesion Molecules (CAMs) Pathway antibodies	Cell Adhesion Molecules (CAMs) Pathway Diagram
Cell Surface Interactions At The Vascular Wall Pathway antibodies	Cell Surface Interactions At The Vascular Wall Pathway Diagram
Epstein-Barr Virus Infection Pathway antibodies	Epstein-Barr Virus Infection Pathway Diagram
Epstein-Barr Virus Infection Pathway antibodies	Epstein-Barr Virus Infection Pathway Diagram
Hemostasis Pathway antibodies	Hemostasis Pathway Diagram

Diseases associated with CD58 active protein

Disease Name	Pubmed Publications
Immune System Diseases Antibodies	>208 publications with CD58 and Immune System Diseases
Necrosis Antibodies	>112 publications with CD58 and Necrosis
Leukemia Antibodies	>108 publications with CD58 and Leukemia
Nervous System Diseases Antibodies	>46 publications with CD58 and Nervous System Diseases
Inflammation Antibodies	>45 publications with CD58 and Inflammation
Cardiovascular Diseases Antibodies	>28 publications with CD58 and Cardiovascular Diseases
Multiple Sclerosis Antibodies	>26 publications with CD58 and Multiple Sclerosis
Anemia Antibodies	>23 publications with CD58 and Anemia
Liver Diseases Antibodies	>23 publications with CD58 and Liver Diseases
Cell Transformation, Neoplastic Antibodies	>23 publications with CD58 and Cell Transformation, Neoplastic

Organs/Tissues associated with CD58 active protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>762 publications with CD58 and Blood
Bone Antibodies	>90 publications with CD58 and Bone
Bone Marrow Antibodies	>85 publications with CD58 and Bone Marrow
Skin Antibodies	>41 publications with CD58 and Skin
Lung Antibodies	>33 publications with CD58 and Lung
Liver Antibodies	>31 publications with CD58 and Liver
Brain Antibodies	>26 publications with CD58 and Brain
Embryonic Tissue Antibodies	>20 publications with CD58 and Embryonic Tissue
Lymph Node Antibodies	>19 publications with CD58 and Lymph Node
Kidney Antibodies	>19 publications with CD58 and Kidney