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LITAF Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS847135

Lipopolysaccharide is a potent stimulator of monocytes and macrophages, causing secretion of tumor necrosis factor-alpha (TNF-alpha) and other inflammatory mediators. This gene encodes lipopolysaccharide-induced TNF-alpha factor, which is a DNA-binding… More details

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Product Overview

Product Name
LITAF, Polyclonal Antibody
Full Product Name
Anti-LITAF (KO validated) Antibody
Product Gene Name
anti-LITAF antibody
Product Synonym Names
LITAF; PIG7; SIMPLE; TP53I7
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Rat, Mouse, Human
Form/Format
Colorless liquid. In PBS with 0.02% sodium azide; 50% glycerol; pH7.3
Purity/Purification
Affinity purified
Specificity
Rabbit polyclonal knockout validated antibody to detect the expression of LITAF in human; mouse and rat samples
Preparation and Storage
Store at -20 degree C. The antibody solution should be gently mixed before use.
Shipping: Gel Pack
Shelf Life: Est.~12 months
Country of Origin: USA
Molecular Weight
15,824 Da
OMIM
601098
3D Structure
ModBase 3D Structure for Q99732
Antibody Target
LITAF
Immunogen
Recombinant fusion protein targeting a sequence around aa 1-161 of human LITAF

Product Categories/Family for anti-LITAF antibody

Web Categories; Antibodies & Supporting Tools; Primary Antibodies (A-Z); Web Categories; Proteins and Enzymes; Cytokines; Growth Factors & Hormones; Antibodies to Cytokines & Growth Factors (A-Z); Cytokines; Antibodies to Cytokines & Growth Factors (A-Z);
Applications Tested/Suitable for anti-LITAF antibody
Immunohistochemistry (IHC); Western Blotting (WB)
Application Notes for anti-LITAF antibody
WB: 1:500-1:2000
IHC: 1:50-1:200
IP:1:50-1:100

Immunohistochemistry (IHC) of anti-LITAF antibody

Rabbit Anti-LITAF Polyclonal Antibody – Cat# MBS847135

Western Blot (WB) of anti-LITAF antibody

Rabbit Anti-LITAF Polyclonal Antibody, Western Blot (WB) – Cat# MBS847135

Western Blot (WB) of anti-LITAF antibody

Rabbit Anti-LITAF Polyclonal Antibody, Western Blot (WB) – Cat# MBS847135

Other Notes

Small volumes of anti-LITAF antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for LITAF purchase

MBS847135 is an antibody targeting LITAF. Also known as Anti-LITAF (KO validated) Antibody. Reactive in Rat, Mouse, Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for LITAF. It may not necessarily be applicable to this product.

NCBI GI #
210147505
NCBI GeneID
9516
NCBI Accession #
NP_001129944.1
UniProt Primary Accession #
Q99732
UniProt Secondary Accession #
Q05DW0; Q9C0L6; D3DUG1; G5E9K0
UniProt Related Accession #
Q99732
GenBank Nucleotide #
NM_001136472.1
NCBI Official Full Name
lipopolysaccharide-induced tumor necrosis factor-alpha factor isoform 1
NCBI Official Synonym Full Names
lipopolysaccharide-induced TNF factor
NCBI Official Symbol
LITAF
NCBI Official Synonym Symbols
PIG7; SIMPLE; TP53I7
UniProt Protein Name
Lipopolysaccharide-induced tumor necrosis factor-alpha factor
UniProt Synonym Protein Names
Small integral membrane protein of lysosome/late endosome; p53-induced gene 7 protein
Protein Family
Cell death-inducing p53-target protein
UniProt Gene Name
LITAF
UniProt Synonym Gene Names
PIG7; SIMPLE; LPS-induced TNF-alpha factor
UniProt Entry Name
LITAF_HUMAN
NCBI Protein Information
lipopolysaccharide-induced tumor necrosis factor-alpha factor; LPS-induced TNF-alpha factor; lipopolysaccharide-induced TNF-alpha factor; p53-induced gene 7 protein; small integral membrane protein of lysosome/late endosome; tumor protein p53 inducible pr

UniProt Comments for LITAF

LITAF: Probable role in regulating transcription of specific genes. May regulate through NFKB1 the expression of the CCL2/MCP-1 chemokine. May play a role in tumor necrosis factor alpha (TNF- alpha) gene expression. Interacts with NEDD4. Interacts with WWOX. Isoform 2 may interact with STAT6. By bacterial lipopolysaccharides (LPS) or p53/TP53. In monocytes by the Bacillus Calmette-Guerin (BCG). Ubiquitously and abundantly expressed. Expressed predominantly in the placenta, peripheral blood leukocytes, lymph nodes and spleen. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription factor; Oncoprotein

Chromosomal Location of Human Ortholog: 16p13.13

Cellular Component: nucleoplasm; Golgi apparatus; intracellular membrane-bound organelle; lysosomal membrane; cytoplasm; plasma membrane

Molecular Function: protein binding; signal transducer activity; WW domain binding

Biological Process: regulation of transcription from RNA polymerase II promoter; positive regulation of I-kappaB kinase/NF-kappaB cascade; transcription, DNA-dependent; apoptosis; negative regulation of NF-kappaB import into nucleus; signal transduction; aging; regulation of cytokine production

Disease: Charcot-marie-tooth Disease, Demyelinating, Type 1c
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Research Articles on LITAF

1. Early-onset hereditary neuropathy with liability to pressure palsy (HNPP) was associated frequently with isoleucine92valine LITAF polymorphism.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-LITAF antibody

 Reference Product  PubMed Publications
 TSG101 antibody  >3 publications with LITAF and TSG101
 NEDD4 antibody  >3 publications with LITAF and NEDD4

Diseases associated with anti-LITAF antibody

 Disease Name  Pubmed Publications
 Necrosis Antibodies  >63 publications with LITAF and Necrosis
 Inflammation Antibodies  >18 publications with LITAF and Inflammation
 Death Antibodies  >7 publications with LITAF and Death
 Liver Diseases Antibodies  >5 publications with LITAF and Liver Diseases
 Hyperplasia Antibodies  >3 publications with LITAF and Hyperplasia
 Charcot-Marie-Tooth disease, Type 1C Antibodies  >3 publications with LITAF and Charcot-Marie-Tooth disease, Type 1C
 Nerve Degeneration Antibodies  >2 publications with LITAF and Nerve Degeneration
 Heart Diseases Antibodies  >2 publications with LITAF and Heart Diseases
 Brain Diseases Antibodies  >2 publications with LITAF and Brain Diseases
 Atherosclerosis Antibodies  >2 publications with LITAF and Atherosclerosis

Organs/Tissues associated with anti-LITAF antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >30 publications with LITAF and Blood
 Nerve Antibodies  >21 publications with LITAF and Nerve
 Intestine Antibodies  >17 publications with LITAF and Intestine
 Spleen Antibodies  >16 publications with LITAF and Spleen
 Muscle Antibodies  >13 publications with LITAF and Muscle
 Liver Antibodies  >11 publications with LITAF and Liver
 Heart Antibodies  >10 publications with LITAF and Heart
 Kidney Antibodies  >5 publications with LITAF and Kidney
 Bone Antibodies  >4 publications with LITAF and Bone
 Lung Antibodies  >4 publications with LITAF and Lung
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