AVPR1A: Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Has been involved in social behaviors, including affiliation and attachment. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.
Protein type: Membrane protein, multi-pass; Membrane protein, integral; Receptor, GPCR; GPCR, family 1
Chromosomal Location of Human Ortholog: 12q14-q15
Cellular Component: integral to plasma membrane; plasma membrane; cytoplasmic vesicle; endosome
Molecular Function: protein binding; protein kinase C binding; peptide hormone binding; V1A vasopressin receptor binding; peptide binding; vasopressin receptor activity
Biological Process: blood circulation; positive regulation of glutamate secretion; positive regulation of cellular pH reduction; cellular response to water deprivation; positive regulation of systemic arterial blood pressure; elevation of cytosolic calcium ion concentration; positive regulation of cell proliferation; positive regulation of prostaglandin biosynthetic process; penile erection; response to corticosterone stimulus; grooming behavior; generation of precursor metabolites and energy; maternal behavior; calcium-mediated signaling; myotube differentiation; positive regulation of heart rate; social behavior; positive regulation of cell growth; cellular response to hormone stimulus; negative regulation of female receptivity; G-protein coupled receptor protein signaling pathway; telencephalon development; negative regulation of transmission of nerve impulse; regulation of systemic arterial blood pressure by vasopressin; phospholipase C activation; positive regulation of vasoconstriction; sperm ejaculation
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