Human Anti-PD-1 Monoclonal Antibody – Cat# MBS847180

PD-1 Antibody – Human Monoclonal

Name: PD-1 Antibody; Monoclonal; Human; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS847180
Price: 600 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS847180

Nivolumab, trade name Opdivo, is a medication used to treat cancer. It is used as a first line treatment for inoperable or metastatic melanoma in combination with ipilimumab if the cancer does not have a mutation in BRAF, as a second-line treatment following… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

PD-1, Monoclonal Antibody

Full Product Name

Anti-PD-1 (Nivolumab), Humanized Antibody

Product Gene Name

anti-PD-1 antibody

Product Synonym Names

Opdivo; PD-1

Clonality

Monoclonal

Isotype

Human IgG4

Host

Human

Species Reactivity

Human

Form/Format

Colorless liquid. In phosphate buffered saline, pH7.6

Purity/Purification

Affinity purification. IgG purified from CHO culture supernatant by protein A chromatography

Specificity

Monoclonal human IgG1 antibody against human PD-1. Opvido (bio-similar) is a human monoclonal antibody that blocks the interaction between PD-1 andits ligands, PD-L1 and PD-L2. Opvido(biosimilar) is an IgG4 Kappa immunoglobulin that has a calculated molecular mass of 146 kDa.

Preparation and Storage

Store at -20 degree C
The antibody solution should be gently mixed before use
Shelf life: ~12 months

Molecular Weight

31,842 Da

3D Structure

ModBase 3D Structure for Q02242

Gene Source

CHO cells

Immunogen

Human programmed cell death 1 receptor (PD1)

Product Categories/Family for anti-PD-1 antibody

Applications Tested/Suitable for anti-PD-1 antibody

Neutralization, ELISA (EIA)

Application Notes for anti-PD-1 antibody

Neutralization: 0.1-1ug/ml
ELISA: 1ug/ml

Other Notes

Small volumes of anti-PD-1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PD-1 purchase

MBS847180 is an antibody targeting PD-1. Also known as Anti-PD-1 (Nivolumab), Humanized Antibody. Reactive in Human. Host: Human.

Additional Details

NCBI/Uniprot data below describe general gene information for PD-1. It may not necessarily be applicable to this product.

NCBI GI #

400743

NCBI GeneID

18566

NCBI Accession #

Q02242.1

UniProt Primary Accession #

Q02242

UniProt Related Accession #

Q02242

NCBI Official Full Name

Programmed cell death protein 1

NCBI Official Synonym Full Names

programmed cell death 1

NCBI Official Symbol

Pdcd1

NCBI Official Synonym Symbols

PD-1; Pdc1; Ly101

UniProt Protein Name

Programmed cell death protein 1

UniProt Synonym Protein Names

CD_antigen: CD279

UniProt Gene Name

Pdcd1

UniProt Synonym Gene Names

Pd1; Protein PD-1; mPD-1

UniProt Entry Name

PDCD1_MOUSE

NCBI Protein Information

programmed cell death protein 1; mPD-1; protein PD-1

UniProt Comments for PD-1

PDCD1: a single-pass type I membrane protein. A negative regulator of activated T cells, is upregulated in human and mouse 'exhausted' T cells during persistent viral infection. A marker of angioimmunoblastic T-cell lymphoma and germinal center associated T cells.

Protein type: Apoptosis; Membrane protein, integral

Cellular Component: external side of plasma membrane; plasma membrane

Molecular Function: protein binding

Biological Process: negative regulation of apoptosis; negative regulation of tolerance induction; positive regulation of apoptosis

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-PD-1 antibody

Reference Product	PubMed Publications
Cd4 antibody	>391 publications with PD-1 and Cd4
Cd274 antibody	>316 publications with PD-1 and Cd274
Pdcd1lg2 antibody	>94 publications with PD-1 and Pdcd1lg2
Ptpn6 antibody	>7 publications with PD-1 and Ptpn6
Ptpn11 antibody	>7 publications with PD-1 and Ptpn11
Lck antibody	>3 publications with PD-1 and Lck
Cd247 antibody	>1 publications with PD-1 and Cd247
Cd3e antibody	>1 publications with PD-1 and Cd3e

Pathways associated with anti-PD-1 antibody

Products by Pathway	Pathway Diagram
Adaptive Immune System Pathway antibodies	Adaptive Immune System Pathway Diagram
Cell Adhesion Molecules (CAMs) Pathway antibodies	Cell Adhesion Molecules (CAMs) Pathway Diagram
Cell Adhesion Molecules (CAMs) Pathway antibodies	Cell Adhesion Molecules (CAMs) Pathway Diagram
Costimulation By The CD28 Family Pathway antibodies	Costimulation By The CD28 Family Pathway Diagram
Immune System Pathway antibodies	Immune System Pathway Diagram
PD-1 Signaling Pathway antibodies	PD-1 Signaling Pathway Diagram
T Cell Receptor Signaling Pathway antibodies	T Cell Receptor Signaling Pathway Diagram
T Cell Receptor Signaling Pathway antibodies	T Cell Receptor Signaling Pathway Diagram

Diseases associated with anti-PD-1 antibody

Disease Name	Pubmed Publications
Liver Diseases Antibodies	>142 publications with PD-1 and Liver Diseases
Inflammation Antibodies	>114 publications with PD-1 and Inflammation
Necrosis Antibodies	>72 publications with PD-1 and Necrosis
Melanoma Antibodies	>71 publications with PD-1 and Melanoma
Lupus Erythematosus, Systemic Antibodies	>70 publications with PD-1 and Lupus Erythematosus, Systemic
Lung Diseases Antibodies	>55 publications with PD-1 and Lung Diseases
Adenocarcinoma Antibodies	>33 publications with PD-1 and Adenocarcinoma
Kidney Diseases Antibodies	>26 publications with PD-1 and Kidney Diseases
Liver Neoplasms Antibodies	>24 publications with PD-1 and Liver Neoplasms
Heart Diseases Antibodies	>19 publications with PD-1 and Heart Diseases

Organs/Tissues associated with anti-PD-1 antibody

Organ/Tissue Name	Pubmed Publications
Thymus Antibodies	>22 publications with PD-1 and Thymus