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TXNRD2 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS847197

Maintains thioredoxin in a reduced state. Implicated in the defenses against oxidative stress. May play a role in redox-regulated cell signaling More details

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Product Overview

Product Name
TXNRD2, Monoclonal Antibody
Full Product Name
Anti-TXNRD2 Antibody (3F2-E12-F10)
Product Gene Name
Product Synonym Names
Thioredoxin reductase 2; mitochondrial; Selenoprotein Z; SelZ; TR-beta; Thioredoxin reductase TR3; KIAA1652; TRXR2
Clonality
Monoclonal
Isotype
Mouse IgG1
Clone Number
3F2-E12-F10
Host
Mouse
Species Reactivity
Human
Form/Format
Colorless liquid. In PBS (pH7.4) containing with 0.02% NaN3 & 50% glycerol
Purity/Purification
Affinity purification
Specificity
Monoclonal antibody to detect endogenous levels of TXNRD2. Does not cross-react with related proteins.
Preparation and Storage
Store at -20 degree C
The antibody solution should be gently mixed before use
Shelf life: ~12 months
Molecular Weight
56,507 Da
Chromosome Location
Chromosome: 22; NC_000022.10 (19863040..19929359, complement). Location: 22q11.21
OMIM
606448
3D Structure
ModBase 3D Structure for Q9NNW7
Immunogen
Recombinant human TXNRD2 protein fragments expressed in E Coli
Positive Control
WB: A431, U251, U2OS, Lncap and Hela cell lysates
Applications Tested/Suitable for anti-TXNRD2 antibody
Western Blot (WB)
Application Notes for anti-TXNRD2 antibody
WB: 1:1000

Western Blot (WB) of anti-TXNRD2 antibody

Mouse Anti-TXNRD2 Monoclonal Antibody – Cat# MBS847197

Other Notes

Small volumes of anti-TXNRD2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TXNRD2 purchase

MBS847197 is an antibody targeting TXNRD2. Also known as Anti-TXNRD2 Antibody (3F2-E12-F10). Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for TXNRD2. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
thioredoxin reductase 2, mitochondrial
NCBI Official Synonym Full Names
thioredoxin reductase 2
NCBI Official Symbol
TXNRD2
NCBI Official Synonym Symbols
TR; TR3; SELZ; TRXR2; TR-BETA
UniProt Protein Name
Thioredoxin reductase 2, mitochondrial
UniProt Synonym Protein Names
Selenoprotein Z; SelZ; TR-beta; Thioredoxin reductase TR3
UniProt Gene Name
TXNRD2
UniProt Synonym Gene Names
KIAA1652; TRXR2; SelZ
UniProt Entry Name
TRXR2_HUMAN
NCBI Protein Information
thioredoxin reductase 2, mitochondrial; selenoprotein Z; thioredoxin reductase 3; thioredoxin reductase TR3; thioredoxin reductase beta

NCBI Summary for TXNRD2

Thioredoxin reductase (TR) is a dimeric NADPH-dependent FAD containing enzyme that catalyzes the reduction of the active site disulfide of thioredoxin and other substrates. TR is a member of a family of pyridine nucleotide-disulfide oxidoreductases and is a key enzyme in the regulation of the intracellular redox environment. Three thioredoxin reductase genes have been found that encode selenocysteine containing proteins. This gene partially overlaps the COMT gene on chromosome 22. [provided by RefSeq, Jul 2008]
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UniProt Comments for TXNRD2

TXNRD2: Maintains thioredoxin in a reduced state. Implicated in the defenses against oxidative stress. May play a role in redox- regulated cell signaling. Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Nucleotide Metabolism - pyrimidine; EC 1.8.1.9; Nuclear receptor co-regulator; Oxidoreductase

Chromosomal Location of Human Ortholog: 22q11.21

Cellular Component: mitochondrion; mitochondrial matrix

Molecular Function: protein binding; thioredoxin-disulfide reductase activity; mercury (II) reductase activity; FAD binding; mercury ion binding; NADP binding

Biological Process: response to reactive oxygen species; response to oxygen radical; cell redox homeostasis; detoxification of mercury ion
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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