Mouse Anti-IMP3 Monoclonal Antibody – Cat# MBS847208

IMP3 Antibody – Mouse Monoclonal

Name: IMP3 Antibody; Monoclonal; Mouse; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS847208
Price: 390 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS847208

RNA-binding factor that may recruit target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

IMP3, Monoclonal Antibody

Full Product Name

Anti-IMP3 Antibody (1F1-E10-D11)

Product Gene Name

anti-IMP3 antibody

Product Synonym Names

Insulin-like growth factor 2 mRNA-binding protein 3; IGF2 mRNA-binding protein 3; IMP-3; IGF-II mRNA-binding protein 3; KH domain-containing protein overexpressed in cancer; hKOC; VICKZ family member 3

Clonality

Monoclonal

Isotype

Mouse IgG1

Clone Number

1F1-E10-D11

Host

Mouse

Species Reactivity

Human

Form/Format

Colorless liquid. In PBS (pH7.4) containing with 0.02% sodium azide and 50% glycerol

Purity/Purification

Affinity purification

Specificity

Monoclonal antibody to detect endogenous levels of IMP3. Does not cross-react with related proteins. Does not cross-react with related proteins.

Preparation and Storage

Store at -20 degree C
The antibody solution should be gently mixed before use
Shelf life: ~12 months

Molecular Weight

63,705 Da

Chromosome Location

Chromosome: 7; NC_000007.13 (23349828..23509995, complement). Location: 7p11

OMIM

608259

3D Structure

ModBase 3D Structure for O00425

Immunogen

Recombinant human IMP3 protein fragments expressed in E Coli

Positive Control

WB: MCF7, SKVO3, NTERA2, Jurkat, Hela and K562 cell lysates

Product Categories/Family for anti-IMP3 antibody

Epigenetics; Antibodies & Supporting Tools; Antibodies for Epigenetics; Research; Primary Antibodies (A-Z)

Applications Tested/Suitable for anti-IMP3 antibody

Western Blot (WB)

Application Notes for anti-IMP3 antibody

WB: 1:1000

Other Notes

Small volumes of anti-IMP3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IMP3 purchase

MBS847208 is an antibody targeting IMP3. Also known as Anti-IMP3 Antibody (1F1-E10-D11). Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for IMP3. It may not necessarily be applicable to this product.

NCBI GI #

30795212

NCBI GeneID

10643

NCBI Accession #

NP_006538.2

UniProt Primary Accession #

O00425

UniProt Secondary Accession #

Q63HM0; Q6MZZ2; Q86VB1; A0A4Z5

UniProt Related Accession #

O00425

GenBank Nucleotide #

NM_006547.2

NCBI Official Full Name

insulin-like growth factor 2 mRNA-binding protein 3

NCBI Official Synonym Full Names

insulin-like growth factor 2 mRNA binding protein 3

NCBI Official Symbol

IGF2BP3

NCBI Official Synonym Symbols

CT98; IMP3; KOC1; IMP-3; VICKZ3

UniProt Protein Name

Insulin-like growth factor 2 mRNA-binding protein 3

UniProt Synonym Protein Names

IGF-II mRNA-binding protein 3; KH domain-containing protein overexpressed in cancer; hKOC; VICKZ family member 3

Protein Family

U3 small nucleolar ribonucleoprotein protein

UniProt Gene Name

IGF2BP3

UniProt Synonym Gene Names

IMP3; KOC1; VICKZ3; IGF2 mRNA-binding protein 3; IMP-3; hKOC

UniProt Entry Name

IF2B3_HUMAN

NCBI Protein Information

insulin-like growth factor 2 mRNA-binding protein 3; hKOC; VICKZ family member 3; cancer/testis antigen 98; IGF2 mRNA-binding protein 3; IGF II mRNA binding protein 3; IGF-II mRNA-binding protein 3; KH domain containing protein overexpressed in cancer; KH

NCBI Summary for IMP3

The protein encoded by this gene is primarily found in the nucleolus, where it can bind to the 5' UTR of the insulin-like growth factor II leader 3 mRNA and may repress translation of insulin-like growth factor II during late development. The encoded protein contains several KH domains, which are important in RNA binding and are known to be involved in RNA synthesis and metabolism. A pseudogene exists on chromosome 7, and there are putative pseudogenes on other chromosomes. [provided by RefSeq, Jul 2008]

UniProt Comments for IMP3

IGF2BP3: RNA-binding protein that act as a regulator of mRNA translation and stability. Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs. Binds to sequences in the 3'-UTR of CD44 mRNA. Belongs to the RRM IMP/VICKZ family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: RNA-binding; Spliceosome; Translation

Chromosomal Location of Human Ortholog: 7p11

Cellular Component: cytoplasm; cytosol; nucleus

Molecular Function: protein binding; mRNA 3'-UTR binding; RNA binding; nucleotide binding; translation regulator activity; mRNA 5'-UTR binding

Biological Process: anatomical structure morphogenesis; mRNA transport; translation; negative regulation of translation; gene expression; regulation of cytokine biosynthetic process

Research Articles on IMP3

1. IGF2BP3 expression is an additional predictor of poor prognosis in pediatric pilocytic and pilomyxoid astrocytoma.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-IMP3 antibody

Products by Pathway	Pathway Diagram
Binding Of RNA By Insulin-like Growth Factor-2 MRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) Pathway antibodies	Binding Of RNA By Insulin-like Growth Factor-2 MRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) Pathway Diagram
Gene Expression Pathway antibodies	Gene Expression Pathway Diagram

Diseases associated with anti-IMP3 antibody

Disease Name	Pubmed Publications
Neoplasms Antibodies	>13 publications with IMP3 and Neoplasms
Carcinoma Antibodies	>10 publications with IMP3 and Carcinoma
Pancreatic Neoplasms Antibodies	>2 publications with IMP3 and Pancreatic Neoplasms
Liver Diseases Antibodies	>2 publications with IMP3 and Liver Diseases
Ovarian Neoplasms Antibodies	>2 publications with IMP3 and Ovarian Neoplasms
Neoplasms, Experimental Antibodies	>1 publications with IMP3 and Neoplasms, Experimental
Recurrence Antibodies	>1 publications with IMP3 and Recurrence
Liver Neoplasms Antibodies	>1 publications with IMP3 and Liver Neoplasms
Neoplasm Metastasis Antibodies	>1 publications with IMP3 and Neoplasm Metastasis
Abnormalities, Multiple Antibodies	>1 publications with IMP3 and Abnormalities, Multiple

Organs/Tissues associated with anti-IMP3 antibody

Organ/Tissue Name	Pubmed Publications
Pancreas Antibodies	>2 publications with IMP3 and Pancreas
Blood Antibodies	>2 publications with IMP3 and Blood
Liver Antibodies	>2 publications with IMP3 and Liver
Brain Antibodies	>2 publications with IMP3 and Brain
Placenta Antibodies	>2 publications with IMP3 and Placenta
Embryonic Tissue Antibodies	>2 publications with IMP3 and Embryonic Tissue
Lung Antibodies	>1 publications with IMP3 and Lung
Uterus Antibodies	>1 publications with IMP3 and Uterus
Lymph Antibodies	>1 publications with IMP3 and Lymph
Bone Marrow Antibodies	>1 publications with IMP3 and Bone Marrow