KIAA1967 Antibody – Mouse Monoclonal

DBC-1: Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions. Inhibits SIRT1 deacetylase activity leading to increasing levels of p53/TP53 acetylation and p53-mediated apoptosis. Inhibits SUV39H1 methyltransferase activity. Component of the DBIRD complex. Interacts with ZNF326/ZIRD; the interaction is direct. Interacts (via N-terminus) with SIRT1. Interacts (via N-terminus) with SUV39H1; this interaction abolishes the interaction with SIRT1. Expressed ubiquitously in normal tissues. Expressed in 84 to 100% of neoplastic breast, lung, and colon tissues. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: RNA-binding; Nuclear receptor co-regulator; Mitochondrial; Apoptosis; Tumor suppressor

Chromosomal Location of Human Ortholog: 8p22

Cellular Component: nucleoplasm; spliceosome; mitochondrial matrix; nuclear chromatin; cytoplasm; nucleus

Molecular Function: enzyme inhibitor activity; protein binding; enzyme binding

Biological Process: positive regulation of apoptosis; RNA splicing; negative regulation of catalytic activity; rhythmic process; regulation of protein stability; mitochondrial fragmentation during apoptosis; mRNA processing; regulation of circadian rhythm; cell cycle; response to DNA damage stimulus; regulation of RNA elongation; negative regulation of proteasomal ubiquitin-dependent protein catabolic process; response to UV