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Blood Group Antigen A (CD173) Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS847314

This antibody recognizes human blood group A (monofucosyl and difucosyl A antigens with chain types 1, 2, 3, 4, 5, 6) and Forssmann antigen. Blood-group antigens are generally defined as molecules formed by sequential addition of saccharides to the… More details

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Product Overview

Product Name
Blood Group Antigen A (CD173), Monoclonal Antibody
Full Product Name
Anti-Blood Group Antigen A Antibody (CD173) (HE-193)
Product Gene Name
anti-CD173 antibody
Product Synonym Names
A transferase; ABO; B transferase; CD173; Fucosylglycoprotein 3-alpha-galactosyltransferase; Fucosylglycoprotein alpha-N-acetylgalactosaminyltransferase; Glycoprotein-fucosylgalactoside alpha-galactosyltransferase; Glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase; Histo-blood group A transferase; Histo-blood group B transferase; NAGAT
Clonality
Monoclonal
Isotype
Mouse IgM, kappa
Clone Number
HE-193
Host
Mouse
Species Reactivity
Human
Form/Format
Colorless liquid. In 10mM PBS with 0.05% BSA & 0.05% azide
Purity/Purification
Protein A/G purification
Specificity
Monoclonal antibody to detect Blood Group Antigen A Antibody (CD173)in human samples
Preparation and Storage
Store at -20 degree C
The antibody solution should be gently mixed before use.
Shelf life: ~12 months
Molecular Weight
354
OMIM
110300
3D Structure
ModBase 3D Structure for P16442
Immunogen
Mixture of erythrocytes of blood group A and glycoprotein fraction isolated from the saliva of secretors with blood group A
Positive Control
IHC: Colon carcinoma

Product Categories/Family for anti-CD173 antibody

Immunology; Antibodies & Supporting Tools; IHC Tested Antibodies
Applications Tested/Suitable for anti-CD173 antibody
Agglutination, Immunofluorescence (IF), Immunohistochemistry (IHC)
Application Notes for anti-CD173 antibody
IF: 0.5-1ug/ml
IHC: 0.5-1ug/ml

ELISA (EIA) of anti-CD173 antibody

Mouse Anti-CD173 Monoclonal Antibody – Cat# MBS847314

Flow Cytometry (FC/FACS) of anti-CD173 antibody

Mouse Anti-CD173 Monoclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS847314

Other Notes

Small volumes of anti-CD173 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CD173 purchase

MBS847314 is an antibody targeting CD173. Also known as Anti-Blood Group Antigen A Antibody (CD173) (HE-193). Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for CD173. It may not necessarily be applicable to this product.

NCBI GI #
114949
NCBI GeneID
28
NCBI Accession #
P16442.2
UniProt Primary Accession #
P16442
UniProt Secondary Accession #
O14758; Q14490; Q53I57; Q6ISD4; Q6KFZ2; Q70V27; Q99484; Q99485; Q9NY01; Q9UQ68; B0JDB9
UniProt Related Accession #
P16442
NCBI Official Full Name
Histo-blood group ABO system transferase
NCBI Official Synonym Full Names
ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)
NCBI Official Symbol
ABO
NCBI Official Synonym Symbols
GTB; NAGAT; A3GALNT; A3GALT1
UniProt Protein Name
Histo-blood group ABO system transferase
UniProt Synonym Protein Names
Fucosylglycoprotein 3-alpha-galactosyltransferase; Fucosylglycoprotein alpha-N-acetylgalactosaminyltransferase; Glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase (EC:2.4.1.40); Glycoprotein-fucosylgalactoside alpha-galactosyltransferase (EC:2.4.1.37); Histo-blood group A transferase; A transferase; Histo-blood group B transferase; B transferase; NAGATFucosylglycoprotein alpha-N-acetylgalactosaminyltransferase soluble form
UniProt Gene Name
ABO
UniProt Synonym Gene Names
A transferase; B transferase
UniProt Entry Name
BGAT_HUMAN
NCBI Protein Information
histo-blood group ABO system transferase; ABO weak transfer; ABO A3 transferase; ABO glycosyltransferase; histo-blood group A transferase; histo-blood group B transferase; histo-blood group A2 transferase; B(A) alpha-1,3-galactosyltransferase; fucosylglyc

NCBI Summary for CD173

This gene encodes proteins related to the first discovered blood group system, ABO. Which allele is present in an individual determines the blood group. The 'O' blood group is caused by a deletion of guanine-258 near the N-terminus of the protein which results in a frameshift and translation of an almost entirely different protein. Individuals with the A, B, and AB alleles express glycosyltransferase activities that convert the H antigen into the A or B antigen. Other minor alleles have been found for this gene. [provided by RefSeq, Jul 2008]
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UniProt Comments for CD173

ABO: This protein is the basis of the ABO blood group system. The histo-blood group ABO involves three carbohydrate antigens: A, B, and H. A, B, and AB individuals express a glycosyltransferase activity that converts the H antigen to the A antigen (by addition of UDP-GalNAc) or to the B antigen (by addition of UDP-Gal), whereas O individuals lack such activity. Belongs to the glycosyltransferase 6 family.

Protein type: Glycan Metabolism - glycosphingolipid biosynthesis - lacto and neolacto series; EC 2.4.1.37; Membrane protein, integral; EC 2.4.1.40; Transferase

Chromosomal Location of Human Ortholog: 9q34.2

Cellular Component: integral to membrane; extracellular region

Molecular Function: metal ion binding; glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase activity; fucosylgalactoside 3-alpha-galactosyltransferase activity

Biological Process: protein amino acid glycosylation

Disease: Blood Group, Abo System
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Research Articles on CD173

1. The rs495828 polymorphism of the ABO gene was associated with enalapril-induced cough and may serve as a useful pharmacogenomics marker of the safety of enalapril in Chinese patients with essential hypertension.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-CD173 antibody

 Products by Pathway  Pathway Diagram
 Glycosphingolipid Biosynthesis - Lacto And Neolacto Series Pathway antibodies  Glycosphingolipid Biosynthesis - Lacto And Neolacto Series Pathway Diagram
 Glycosphingolipid Biosynthesis - Lacto And Neolacto Series Pathway antibodies  Glycosphingolipid Biosynthesis - Lacto And Neolacto Series Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram

Diseases associated with anti-CD173 antibody

 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >923 publications with CD173 and Cardiovascular Diseases
 Death Antibodies  >650 publications with CD173 and Death
 Kidney Diseases Antibodies  >447 publications with CD173 and Kidney Diseases
 Heart Diseases Antibodies  >374 publications with CD173 and Heart Diseases
 Inflammation Antibodies  >270 publications with CD173 and Inflammation
 Diabetes Mellitus Antibodies  >235 publications with CD173 and Diabetes Mellitus
 Liver Failure Antibodies  >232 publications with CD173 and Liver Failure
 Urinary Bladder Neoplasms Antibodies  >220 publications with CD173 and Urinary Bladder Neoplasms
 Hypertension Antibodies  >180 publications with CD173 and Hypertension
 Necrosis Antibodies  >173 publications with CD173 and Necrosis

Organs/Tissues associated with anti-CD173 antibody

 Organ/Tissue Name  Pubmed Publications
 Eye Antibodies  >942 publications with CD173 and Eye
 Bone Marrow Antibodies  >628 publications with CD173 and Bone Marrow
 Lung Antibodies  >404 publications with CD173 and Lung
 Intestine Antibodies  >352 publications with CD173 and Intestine
 Bladder Antibodies  >267 publications with CD173 and Bladder
 Mouth Antibodies  >266 publications with CD173 and Mouth
 Pancreas Antibodies  >143 publications with CD173 and Pancreas
 Salivary Gland Antibodies  >117 publications with CD173 and Salivary Gland
 Esophagus Antibodies  >41 publications with CD173 and Esophagus
 Testis Antibodies  >37 publications with CD173 and Testis
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