Human Anti-CD22 Monoclonal Antibody – Cat# MBS847317

CD22 Antibody – Human Monoclonal

Name: CD22 Antibody; Monoclonal; Human; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS847317
Price: 865 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS847317

Recombinant monoclonal antibody to CD22. Manufactured using Recombinant Platform with variable regions (i.e. specificity) from the hybridoma hL22 (Epratuzumab) . More details

DISCONTINUED
Click here to view our similar product(s) OR click here to contact our technical support team for suitable replacement.

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

CD22, IgG1, Monoclonal Antibody

Full Product Name

Anti-CD22 (Epratuzumab), Human IgG1 Antibody

Product Gene Name

anti-CD22 antibody

Product Synonym Names

LymphoCide; B-cell receptor CD22; B-lymphocyte cell adhesion molecule; BL-CAM; Sialic acid-binding Ig-like lectin 2; Siglec-2; T-cell surface antigen Leu-14; SIGLEC2

Clonality

Monoclonal

Isotype

Human IgG1, kappa

Clone Number

hL22

Host

Human

Species Reactivity

Human, Rhesus Monkey, Cynomolgus Monkey

Form/Format

Colorless liquid. In PBS only

Purity/Purification

Affinity purified using Protein A

Specificity

Monoclonal antibody to detect CD22 in human samples. This antibody is specific for the 3rd Ig-like domain of human CD22 (epitope B), a cell surface glycoprotein present on mature B-cells and on many types of malignant B-cells

Preparation and Storage

Store at -20 degree C
The antibody solution should be gently mixed before use.
Shelf life: ~12 months

Molecular Weight

95,348 Da

Chromosome Location

Chromosome: 19; NC_000019.9 (35820072..35838264). Location: 19q13.1

OMIM

107266

3D Structure

ModBase 3D Structure for P20273

Antibody Type

Recombinant Antibody

Immunogen

This antibody was prepared by the humanization of LL2 (EPB-2), a murine anti-CD22 IgG2a raised against Raji Burkitt lymphoma cells. Murine sequences comprise 5-10% of the molecule, with the remainder being human framework sequences, which greatly reduces the potential for immunogenicity (Traczewski, 2010).

Product Categories/Family for anti-CD22 antibody

Immunology; Antibodies & Supporting Tools; Research Grade Biosimilar Antibodies

Other Notes

Small volumes of anti-CD22 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CD22 purchase

MBS847317 is an antibody targeting CD22. Also known as Anti-CD22 (Epratuzumab), Human IgG1 Antibody. Reactive in Human, Rhesus Monkey, Cynomolgus Monkey. Host: Human.

Additional Details

NCBI/Uniprot data below describe general gene information for CD22. It may not necessarily be applicable to this product.

NCBI GI #

297374825

NCBI GeneID

933

NCBI Accession #

NP_001172028.1

UniProt Primary Accession #

P20273

UniProt Secondary Accession #

O95699; O95701; O95702; O95703; Q01665; Q92872; Q92873; Q9UQA6; Q9UQA7; Q9UQA8; F5H7U3

UniProt Related Accession #

P20273

GenBank Nucleotide #

NM_001185099.1

NCBI Official Full Name

B-cell receptor CD22 isoform 2

NCBI Official Synonym Full Names

CD22 molecule

NCBI Official Symbol

CD22

NCBI Official Synonym Symbols

SIGLEC2; SIGLEC-2

UniProt Protein Name

B-cell receptor CD22

UniProt Synonym Protein Names

B-lymphocyte cell adhesion molecule; BL-CAM; Sialic acid-binding Ig-like lectin 2; Siglec-2; T-cell surface antigen Leu-14

Protein Family

B-cell receptor

UniProt Gene Name

CD22

UniProt Synonym Gene Names

SIGLEC2; BL-CAM; Siglec-2

UniProt Entry Name

CD22_HUMAN

NCBI Protein Information

B-cell receptor CD22; BL-CAM; CD22 antigen; T-cell surface antigen Leu-14; B-lymphocyte cell adhesion molecule; sialic acid binding Ig-like lectin 2; sialic acid-binding Ig-like lectin 2

UniProt Comments for CD22

CD22: Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules. Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell surface; Membrane protein, integral

Chromosomal Location of Human Ortholog: 19q13.1

Cellular Component: integral to plasma membrane; external side of plasma membrane

Molecular Function: protein binding; carbohydrate binding

Biological Process: cell adhesion

Research Articles on CD22

1. In the absence of functional CD22, B cells have a "hyperactivated" phenotype, CD22 dysfunction could contribute to the pathogenesis of autoimmune diseases. (Review)

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CD22 antibody

Reference Product	PubMed Publications
CD19 antibody	>563 publications with CD22 and CD19
PTPRC antibody	>116 publications with CD22 and PTPRC
LYN antibody	>40 publications with CD22 and LYN
PTPN6 antibody	>36 publications with CD22 and PTPN6
SYK antibody	>25 publications with CD22 and SYK
GRB2 antibody	>6 publications with CD22 and GRB2
ST6GAL1 antibody	>3 publications with CD22 and ST6GAL1
IGHM antibody	>2 publications with CD22 and IGHM
SHC1 antibody	>1 publications with CD22 and SHC1

Pathways associated with anti-CD22 antibody

Products by Pathway	Pathway Diagram
B Cell Receptor Signaling Pathway antibodies	B Cell Receptor Signaling Pathway Diagram
B Cell Receptor Signaling Pathway antibodies	B Cell Receptor Signaling Pathway Diagram
B Cell Receptor Signaling Pathway antibodies	B Cell Receptor Signaling Pathway Diagram
BCR Signaling Pathway antibodies	BCR Signaling Pathway Diagram
Cell Adhesion Molecules (CAMs) Pathway antibodies	Cell Adhesion Molecules (CAMs) Pathway Diagram
Cell Adhesion Molecules (CAMs) Pathway antibodies	Cell Adhesion Molecules (CAMs) Pathway Diagram
Hematopoietic Cell Lineage Pathway antibodies	Hematopoietic Cell Lineage Pathway Diagram
Hematopoietic Cell Lineage Pathway antibodies	Hematopoietic Cell Lineage Pathway Diagram

Diseases associated with anti-CD22 antibody

Disease Name	Pubmed Publications
Immune System Diseases Antibodies	>891 publications with CD22 and Immune System Diseases
Neoplasms Antibodies	>866 publications with CD22 and Neoplasms
Neoplasms, Experimental Antibodies	>102 publications with CD22 and Neoplasms, Experimental
Drug Toxicity Antibodies	>70 publications with CD22 and Drug Toxicity
Necrosis Antibodies	>50 publications with CD22 and Necrosis
Inflammation Antibodies	>49 publications with CD22 and Inflammation
Bone Marrow Diseases Antibodies	>38 publications with CD22 and Bone Marrow Diseases
Nervous System Diseases Antibodies	>38 publications with CD22 and Nervous System Diseases
Cell Transformation, Neoplastic Antibodies	>22 publications with CD22 and Cell Transformation, Neoplastic
Kidney Diseases Antibodies	>20 publications with CD22 and Kidney Diseases

Organs/Tissues associated with anti-CD22 antibody

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>983 publications with CD22 and Blood
Bone Marrow Antibodies	>273 publications with CD22 and Bone Marrow
Spleen Antibodies	>118 publications with CD22 and Spleen
Lymph Node Antibodies	>105 publications with CD22 and Lymph Node
Lymph Antibodies	>97 publications with CD22 and Lymph
Skin Antibodies	>46 publications with CD22 and Skin
Thymus Antibodies	>31 publications with CD22 and Thymus
Tonsil Antibodies	>29 publications with CD22 and Tonsil
Kidney Antibodies	>29 publications with CD22 and Kidney
Lung Antibodies	>28 publications with CD22 and Lung