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IRISIN Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS847331

Irisin is a recently discovered exercise-induced myokine, which is secreted by skeletal muscles and produced by cleavage of the FNDC5. Studies show that Irisin stimulates mitochondria uncoupling protein-1 (UCP-1; a regulator of thermogenic capability of brown… More details

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Product Overview

Product Name
Irisin, Polyclonal Antibody
Full Product Name
Anti-Irisin Antibody
Product Gene Name
Product Synonym Names
Fibronectin Type III Domain-containing Protein 5; FNDC5 (cleaved); Fibronectin Type III Repeat-containing Protein 2; FRCP2 (cleaved)
Clonality
Polyclonal
Isotype
Rabbit IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Colorless liquid. In PBS pH7.2, containing 30% glycerol, 0.5% BSA, 5mM EDTA and 0.03% Proclin
Purity/Purification
Affinity purified rabbit IgG
Specificity
Polyclonal Antibody to detect Irisin in human, mouse and rat samples
Preparation and Storage
Store at -20 degree C
The antibody solution should be gently mixed before use.
Shelf life: ~12 months
Molecular Weight
15,527 Da
OMIM
611906
3D Structure
ModBase 3D Structure for Q8NAU1
Immunogen
Human recombinant Irisin
Positive Control
WB: Rat kidney lysate, Human recombinant Irisin
Applications Tested/Suitable for anti-Irisin antibody
Western Blot (WB)
Application Notes for anti-Irisin antibody
WB: 1-4ug

Western Blot (WB) of anti-Irisin antibody

Rabbit Anti-IRISIN Polyclonal Antibody – Cat# MBS847331

Other Notes

Small volumes of anti-Irisin antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Irisin purchase

MBS847331 is an antibody targeting Irisin. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for Irisin. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
fibronectin type III domain-containing protein 5 isoform 3 preproprotein
NCBI Official Synonym Full Names
fibronectin type III domain containing 5
NCBI Official Symbol
FNDC5
NCBI Official Synonym Symbols
FRCP2; irisin
UniProt Protein Name
Fibronectin type III domain-containing protein 5
UniProt Synonym Protein Names
Fibronectin type III repeat-containing protein 2Irisin
UniProt Gene Name
FNDC5
UniProt Synonym Gene Names
FRCP2
UniProt Entry Name
FNDC5_HUMAN
NCBI Protein Information
fibronectin type III domain-containing protein 5; fibronectin type III repeat-containing protein 2

NCBI Summary for Irisin

This gene encodes a secreted protein that is released from muscle cells during exercise. The encoded protein may participate in the development of brown fat. Translation of the precursor protein initiates at a non-AUG start codon at a position that is conserved as an AUG start codon in other organisms. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]
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UniProt Comments for Irisin

FNDC5: Irisin: mediates beneficial effects of muscular exercise. Induces browning of white adipose tissue by stimulating UCP1 expression, at least in part, via the nuclear receptor PPARA. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 1p35.1

Cellular Component: peroxisomal membrane; endoplasmic reticulum; plasma membrane; integral to membrane; extracellular region

Molecular Function: hormone activity

Biological Process: response to muscle activity
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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