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CD162 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS847349

CD162 glycoprotein functions as a high affinity counter-receptor for the cell adhesion molecules P-, E- and L- selectin expressed on myeloid cells and stimulated T lymphocytes. As such, this protein plays a critical role in leukocyte trafficking during… More details

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Product Overview

Product Name
CD162, Monoclonal Antibody
Full Product Name
Anti-CD162 Antibody (PSGL1/1601)
Product Gene Name
Product Synonym Names
CD162; CLA; Cutaneous lymphocyte associated antigen; P-selectin glycoprotein ligand 1; PSGL1; Selectin P ligand; SELPLG
Clonality
Monoclonal
Isotype
Mouse IgG1
Clone Number
PSGL1/1601
Host
Mouse
Species Reactivity
Human
Form/Format
Colorless liquid. In 10mM PBS with 0.05% BSA & 0.05% azide
Purity/Purification
Protein A/G purification
Specificity
Monoclonal Antibody to detect CD162 in human samples
Preparation and Storage
Store at -20 degree C
The antibody solution should be gently mixed before use
Shelf life: ~12 months
Molecular Weight
43,201 Da
Chromosome Location
Chromosome: 12; NC_000012.11 (109015671..109027670, complement). Location: 12q24
OMIM
600738
3D Structure
ModBase 3D Structure for Q14242
Immunogen
Recombinant human full-length SELPLG (CD162)protein
Positive Control
IHC: Human Spleen, human Tonsil
Applications Tested/Suitable for anti-CD162 antibody
Flow Cytometry (FC/FACS), Immunofluorescence (IF), Immunohistochemistry (IHC)
Application Notes for anti-CD162 antibody
FC/FACS: 0.5-1ug/1x106 cells
IF: 0.5-1ug/ml
IHC: 1-2ug/ml

Immunohistochemistry (IHC) of anti-CD162 antibody

Mouse Anti-CD162 Monoclonal Antibody – Cat# MBS847349

Immunohistochemistry (IHC) of anti-CD162 antibody

Mouse Anti-CD162 Monoclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS847349

Other Notes

Small volumes of anti-CD162 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CD162 purchase

MBS847349 is an antibody targeting CD162. Also known as Anti-CD162 Antibody (PSGL1/1601). Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for CD162. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
P-selectin glycoprotein ligand 1 isoform 1
NCBI Official Synonym Full Names
selectin P ligand
NCBI Official Symbol
SELPLG
NCBI Official Synonym Symbols
CLA; CD162; PSGL1; PSGL-1
UniProt Protein Name
P-selectin glycoprotein ligand 1
UniProt Synonym Protein Names
Selectin P ligand
UniProt Gene Name
SELPLG
UniProt Synonym Gene Names
PSGL-1
UniProt Entry Name
SELPL_HUMAN
NCBI Protein Information
P-selectin glycoprotein ligand 1; cutaneous lymphocyte-associated associated antigen

NCBI Summary for CD162

This gene encodes a glycoprotein that functions as a high affinity counter-receptor for the cell adhesion molecules P-, E- and L- selectin expressed on myeloid cells and stimulated T lymphocytes. As such, this protein plays a critical role in leukocyte trafficking during inflammation by tethering of leukocytes to activated platelets or endothelia expressing selectins. This protein requires two post-translational modifications, tyrosine sulfation and the addition of the sialyl Lewis x tetrasaccharide (sLex) to its O-linked glycans, for its high-affinity binding activity. Aberrant expression of this gene and polymorphisms in this gene are associated with defects in the innate and adaptive immune response. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Apr 2011]
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UniProt Comments for CD162

SELPLG: A SLe(x)-type glycan, which through high affinity, calcium-dependent interactions with E-, P- and L-selectins, mediates rapid rolling of leukocytes over vascular surfaces during the initial steps in inflammation. PSGL1 is critical for the initial leukocyte capture.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 12q24

Cellular Component: membrane; integral to plasma membrane; plasma membrane; integral to membrane

Molecular Function: protein binding; receptor binding

Biological Process: blood coagulation; cell adhesion; leukocyte tethering or rolling; leukocyte adhesive activation; leukocyte migration
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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