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CD68 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS847412

This antibody recognizes a glycoprotein of 110 kDa, which is identified as CD68. It is important for identifying macrophages in tissue sections. It stains macrophages in a wide variety of human tissues, including Kupffer cells and macrophages in the red pulp… More details

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Product Overview

Product Name
CD68, Monoclonal Antibody
Full Product Name
Anti-CD68 Antibody (C68/684)
Product Gene Name
Product Synonym Names
GP110; LAMP4; Microsialin; Macrosialin; SCARD1; Scavenger Receptor Class D Member-1
Clonality
Monoclonal
Isotype
Mouse IgG1, kappa
Clone Number
C68/684
Host
Mouse
Species Reactivity
Human, Monkey
Form/Format
Colorless liquid. In 10mM PBS with 0.05% BSA & 0.05% azide
Purity/Purification
Protein A/G purification
Specificity
Monoclonal Antibody to detect CD68 in human samples
Preparation and Storage
Store at -20 degree C
The antibody solution should be gently mixed before use
Shelf life: ~12 months
Molecular Weight
37,408 Da
Chromosome Location
Chromosome: 17; NC_000017.10 (7482805..7485429). Location: 17p13
OMIM
153634
3D Structure
ModBase 3D Structure for P34810
Immunogen
Recombinant human CD68 protein
Positive Control
IHC: Human Histiocytoma, human Tonsil
Applications Tested/Suitable for anti-CD68 antibody
Flow Cytometry (FC/FACS), Immunofluorescence (IF), Immunohistochemistry (IHC)
Application Notes for anti-CD68 antibody
FC/FACS: 0.5-1ug/1x106 cells in 0.1 ml
IF: 0.5-1ug/ml
IHC: 0.25-0.5ug/ml for 30 minutes at room temperature

Immunohistochemistry (IHC) of anti-CD68 antibody

Mouse Anti-CD68 Monoclonal Antibody – Cat# MBS847412

Immunohistochemistry (IHC) of anti-CD68 antibody

Mouse Anti-CD68 Monoclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS847412

Other Notes

Small volumes of anti-CD68 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CD68 purchase

MBS847412 is an antibody targeting CD68. Also known as Anti-CD68 Antibody (C68/684). Reactive in Human, Monkey. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for CD68. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
CD68
NCBI Official Synonym Full Names
CD68 molecule
NCBI Official Symbol
CD68
NCBI Official Synonym Symbols
GP110; LAMP4; SCARD1
UniProt Protein Name
Macrosialin
UniProt Synonym Protein Names
Gp110
Protein Family
UniProt Gene Name
CD68
UniProt Entry Name
CD68_HUMAN
NCBI Protein Information
macrosialin; CD68 antigen; macrophage antigen CD68; scavenger receptor class D, member 1

NCBI Summary for CD68

This gene encodes a 110-kD transmembrane glycoprotein that is highly expressed by human monocytes and tissue macrophages. It is a member of the lysosomal/endosomal-associated membrane glycoprotein (LAMP) family. The protein primarily localizes to lysosomes and endosomes with a smaller fraction circulating to the cell surface. It is a type I integral membrane protein with a heavily glycosylated extracellular domain and binds to tissue- and organ-specific lectins or selectins. The protein is also a member of the scavenger receptor family. Scavenger receptors typically function to clear cellular debris, promote phagocytosis, and mediate the recruitment and activation of macrophages. Alternative splicing results in multiple transcripts encoding different isoforms. [provided by RefSeq, Jul 2008]
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UniProt Comments for CD68

CD68: Could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. Binds to tissue- and organ-specific lectins or selectins, allowing homing of macrophage subsets to particular sites. Rapid recirculation of CD68 from endosomes and lysosomes to the plasma membrane may allow macrophages to crawl over selectin-bearing substrates or other cells. Belongs to the LAMP family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell surface; Membrane protein, integral

Chromosomal Location of Human Ortholog: 17p13

Cellular Component: membrane; lysosomal membrane; plasma membrane; integral to membrane; endosome membrane
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-CD68 antibody

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