Mouse Anti-A/CHGA Monoclonal Antibody – Cat# MBS847429

Chromogranin A/CHGA (A/CHGA) Antibody – Mouse Monoclonal

Name: A/CHGA Antibody; Monoclonal; Mouse; MyBioSource
Brand: MyBioSource
SKU: MBS847429
Price: 555 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS847429

Chromogranin A is present in neuroendocrine cells throughout the body, including the neuroendocrine cells of the large and small intestine, adrenal medulla and pancreatic islets. It is an excellent marker for carcinoid tumors, pheochromocytomas,… More details

DISCONTINUED
Click here to view our similar product(s) OR click here to contact our technical support team for suitable replacement.

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

Chromogranin A/CHGA, Monoclonal Antibody

Full Product Name

Anti-Chromogranin A/CHGA Antibody (CGA/413 + CHGA/777 + CHGA/798)

Product Gene Name

anti-A/CHGA antibody

Product Synonym Names

Beta-Granin; CGA; CHGA; Chromogranin A Parathyroid Secretory Protein 1; ER-37; Pancreastatin; Parastatin; Parathyroid Secretory Protein 1; Pituitary Secretory Protein I; SP-I; Vasostatin I or II; Chromogranin A/CHGA

Clonality

Monoclonal

Isotype

Mouse IgG's

Clone Number

CGA/413+CHGA/777+CHGA/798

Host

Mouse

Species Reactivity

Human, Monkey, Pig, Mouse, Rat

Form/Format

Colorless liquid. Supplied in 10mM PBS with 0.05% BSA & 0.05% azide

Purity/Purification

Protein A/G purification

Specificity

Monoclonal Antibody to detect Chromogranin A/CHGA in human samples

Preparation and Storage

Store at -20 degree C
The antibody solution should be gently mixed before use
Shelf life: ~12 months

Molecular Weight

50,688 Da

Chromosome Location

Chromosome: 14; NC_000014.8 (93389445..93401638). Location: 14q32

OMIM

118910

3D Structure

ModBase 3D Structure for P10645

Positive Control

IHC: (A)Pheochromocytoma, (B)Pancreas, (C)Parathyroid, (D)Adrenal Gland

Product Categories/Family for anti-A/CHGA antibody

Tumor Biomarker; Antibodies & Supporting Tools; IHC Tested Antibodies

Applications Tested/Suitable for anti-A/CHGA antibody

Flow Cytometry (FC/FACS), Immunofluorescence (IF), Immunohistochemistry (IHC)

Application Notes for anti-A/CHGA antibody

FC/FACS: 0.5-1ug/1x106 cells in 0.1 ml
IF: 0.5-1ug/ml
IHC: 0.25-0.5ug/ml for 30 minutes at room temperature

Other Notes

Small volumes of anti-A/CHGA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for A/CHGA purchase

MBS847429 is an antibody targeting A/CHGA. Also known as Anti-Chromogranin A/CHGA Antibody (CGA/413 + CHGA/777 + CHGA/798). Reactive in Human, Monkey, Pig, Mouse, Rat. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for A/CHGA. It may not necessarily be applicable to this product.

NCBI GI #

4502805

NCBI GeneID

1113

NCBI Accession #

NP_001266.1

UniProt Primary Accession #

P10645

UniProt Secondary Accession #

Q53FA8; Q6NR84; Q96E84; Q96GL7; Q9BQB5; B2R9E9

UniProt Related Accession #

P10645

GenBank Nucleotide #

NM_001275.3

NCBI Official Full Name

chromogranin-A preproprotein

NCBI Official Synonym Full Names

chromogranin A (parathyroid secretory protein 1)

NCBI Official Symbol

CHGA

NCBI Official Synonym Symbols

CGA

UniProt Protein Name

Chromogranin-A

UniProt Synonym Protein Names

Pituitary secretory protein I; SP-ICleaved into the following 13 chains:Vasostatin-1; Alternative name(s):; Vasostatin IVasostatin-2; Alternative name(s):; Vasostatin II

UniProt Gene Name

CHGA

UniProt Synonym Gene Names

CgA; SP-I

UniProt Entry Name

CMGA_HUMAN

NCBI Protein Information

chromogranin-A; SP-I; pituitary secretory protein I; parathyroid secretory protein 1; betagranin (N-terminal fragment of chromogranin A)

NCBI Summary for A/CHGA

The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. It is found in secretory vesicles of neurons and endocrine cells. This gene product is a precursor to three biologically active peptides; vasostatin, pancreastatin, and parastatin. These peptides act as autocrine or paracrine negative modulators of the neuroendocrine system. Other peptides, including chromostatin, beta-granin, WE-14 and GE-25, are also derived from the full-length protein. However, biological activities for these molecules have not been shown. [provided by RefSeq, Jul 2008]

UniProt Comments for A/CHGA

CHGA: a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. It is found in secretory vesicles of neurons and endocrine cells and is a precursor to multiple biologically active peptides including vasostatin, pancreastatin, and chromostatin. Binds calcium with a low-affinity. Vasostatin negatively regulates angiogenesis and has antibacterial activity against some Gram-positive bacteria. Pancreastatin inhibits glucose induced insulin release from the pancreas. Chromostatin inhibits catecholamine release from chromaffin cells.

Protein type: Secreted, signal peptide; Vesicle; Cell adhesion; Secreted

Chromosomal Location of Human Ortholog: 14q32

Cellular Component: perinuclear region of cytoplasm; extracellular region; secretory granule

Biological Process: regulation of blood pressure

Research Articles on A/CHGA

1. the author showed that, in cutaneous basal cell carcinoma, the expression of NCAM and c-KIT was high, PDGFRA was intermediate, and chromogranin A and synaptophysin was relatively low

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-A/CHGA antibody

Reference Product	PubMed Publications
SYP antibody	>6 publications with A/CHGA and SYP
SCG2 antibody	>3 publications with A/CHGA and SCG2
CALM1 antibody	>1 publications with A/CHGA and CALM1
IGF1 antibody	>1 publications with A/CHGA and IGF1
SCG3 antibody	>1 publications with A/CHGA and SCG3

Diseases associated with anti-A/CHGA antibody

Disease Name	Pubmed Publications
Pheochromocytoma Antibodies	>62 publications with A/CHGA and Pheochromocytoma
Hypertension Antibodies	>54 publications with A/CHGA and Hypertension
Cardiovascular Diseases Antibodies	>49 publications with A/CHGA and Cardiovascular Diseases
Nervous System Diseases Antibodies	>45 publications with A/CHGA and Nervous System Diseases
Brain Diseases Antibodies	>34 publications with A/CHGA and Brain Diseases
Hyperplasia Antibodies	>28 publications with A/CHGA and Hyperplasia
Kidney Diseases Antibodies	>24 publications with A/CHGA and Kidney Diseases
Carcinoma, Non-Small-Cell Lung Antibodies	>22 publications with A/CHGA and Carcinoma, Non-Small-Cell Lung
Liver Diseases Antibodies	>18 publications with A/CHGA and Liver Diseases
Necrosis Antibodies	>10 publications with A/CHGA and Necrosis

Organs/Tissues associated with anti-A/CHGA antibody

Organ/Tissue Name	Pubmed Publications
Nerve Antibodies	>102 publications with A/CHGA and Nerve
Adrenal Gland Antibodies	>79 publications with A/CHGA and Adrenal Gland
Prostate Antibodies	>53 publications with A/CHGA and Prostate
Lung Antibodies	>48 publications with A/CHGA and Lung
Stomach Antibodies	>47 publications with A/CHGA and Stomach
Brain Antibodies	>45 publications with A/CHGA and Brain
Thyroid Antibodies	>42 publications with A/CHGA and Thyroid
Pancreas Antibodies	>32 publications with A/CHGA and Pancreas
Parathyroid Antibodies	>28 publications with A/CHGA and Parathyroid
Kidney Antibodies	>25 publications with A/CHGA and Kidney