Clathrin (CLTA) Antibody – Mouse Monoclonal

Clathrin is a large, soluble protein composed of heavy and light chains. It functions as the main structural component of the lattice-type cytoplasmic face of coated pits and vesicles which entrap specific macromolecules during receptor-mediated endocytosis. This gene encodes one of two clathrin light chain proteins which are believed to function as regulatory elements. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 8 and 12. [provided by RefSeq, May 2010]

CLTA: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Belongs to the clathrin light chain family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Vesicle

Chromosomal Location of Human Ortholog: 9p13

Cellular Component: clathrin coat of trans-Golgi network vesicle; clathrin coat; intracellular membrane-bound organelle; membrane; cytoplasmic membrane-bound vesicle; plasma membrane; trans-Golgi network membrane; cytosol; clathrin coat of coated pit

Molecular Function: protein binding; clathrin heavy chain binding; structural molecule activity; peptide binding

Biological Process: negative regulation of epidermal growth factor receptor signaling pathway; epidermal growth factor receptor signaling pathway; axon guidance; intracellular protein transport; nerve growth factor receptor signaling pathway; antigen processing and presentation of exogenous peptide antigen via MHC class II; endocytosis; post-Golgi vesicle-mediated transport