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Pe-Cyanine 7 (CD3) Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS847437

The OKT3 monoclonal antibody specifically reacts with the epsilon chain of the CD3/T lymphocyte antigen receptor complex. The CD3 complex contains gamma, delta, and epsilon chains, and it is part of the TCR complex, expressed by all mature T lymphocytes and… More details

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Product Overview

Product Name
CD3 PE-Cyanine 7, Monoclonal Antibody
Full Product Name
Anti-Human CD3 PE-Cyanine 7 Antibody (OKT3)
Product Gene Name
Product Synonym Names
T-cell surface glycoprotein CD3 gamma chain; T-cell receptor T3 gamma chain; CD_antigen: CD3g; CD3
Clonality
Monoclonal
Isotype
Mouse IgG2b, kappa
Clone Number
OKT3
Host
Mouse
Species Reactivity
Human
Form/Format
Colorless liquid. Phosphate-buffered aqueous solution, <=0.09% Sodium azide, may contain carrier protein/stabilizer, pH7.2.
Purity/Purification
Affinity chromatography.
Specificity
Mouse monoclonal PE-Cy7 conjugated antibody to detect CD3 in human samples.
Preparation and Storage
Store at 4 degree C
The antibody solution should be gently mixed before use.
Shelf life: ~12 months
OMIM
186740
3D Structure
ModBase 3D Structure for P09693

Product Categories/Family for anti-CD3 antibody

Applications Tested/Suitable for anti-CD3 antibody
Flow Cytometry (FC/FACS)
Application Notes for anti-CD3 antibody
FC/FACS (Cell Surface): 5 ul/1x106 cells per test

Other Notes

Small volumes of anti-CD3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CD3 purchase

MBS847437 is an antibody targeting CD3. Also known as Anti-Human CD3 PE-Cyanine 7 Antibody (OKT3). Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for CD3. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
T-cell surface glycoprotein CD3 gamma chain
NCBI Official Synonym Full Names
CD3g molecule, gamma (CD3-TCR complex)
NCBI Official Symbol
CD3G
NCBI Official Synonym Symbols
T3G; IMD17; CD3-GAMMA
UniProt Protein Name
T-cell surface glycoprotein CD3 gamma chain
UniProt Synonym Protein Names
T-cell receptor T3 gamma chain; CD_antigen: CD3g
UniProt Gene Name
CD3G
UniProt Synonym Gene Names
T3G
UniProt Entry Name
CD3G_HUMAN
NCBI Protein Information
T-cell surface glycoprotein CD3 gamma chain; CD3g antigen, gamma polypeptide (TiT3 complex); CD3g molecule, epsilon (CD3-TCR complex); T-cell antigen receptor complex, gamma subunit of T3; T-cell receptor T3 gamma chain

NCBI Summary for CD3

The protein encoded by this gene is the CD3-gamma polypeptide, which together with CD3-epsilon, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. Defects in this gene are associated with T cell immunodeficiency. [provided by RefSeq, Jul 2008]
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UniProt Comments for CD3

CD3G: The CD3 complex mediates signal transduction.

Protein type: Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 11q23

Cellular Component: T cell receptor complex; integral to plasma membrane; plasma membrane; alpha-beta T cell receptor complex

Molecular Function: receptor signaling complex scaffold activity; transmembrane receptor activity; protein heterodimerization activity; T cell receptor binding

Biological Process: protein transport; regulation of immune response; cell surface receptor linked signal transduction; T cell activation; T cell costimulation; establishment and/or maintenance of cell polarity; innate immune response; protein complex assembly; T cell receptor signaling pathway

Disease: Immunodeficiency 17
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Organs/Tissues associated with anti-CD3 antibody

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