Rabbit Anti-ISLET-1 Polyclonal Antibody – Cat# MBS847495

ISLET-1 Antibody – Rabbit Polyclonal

Name: ISLET-1 Antibody; Polyclonal; Rabbit; Human/Mouse/Rat-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS847495
Price: 430 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS847495

DNA-binding transcriptional activator. Recognizes and binds to the consensus octamer binding site 5'-ATAATTAA-3' in promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation.… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

Islet-1, Polyclonal Antibody

Full Product Name

Anti-Islet-1 Antibody

Product Gene Name

anti-Islet-1 antibody

Product Synonym Names

Insulin gene enhancer protein ISL-1; Islet-1

Clonality

Polyclonal

Isotype

Rabbit IgG

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Form/Format

Colorless liquid. In 0.42% Potassium phosphate; 0.87% Sodium chloride; pH7.3; 30% glycerol and 0.01% sodium azide

Purity/Purification

Affinity purification. The antibody was purified by affinity chromatography

Concentration

1mg/ml (lot specific)

Specificity

Polyclonal antibody to detect endogenous levels of Islet-1 in human, mouse and rat samples

Preparation and Storage

Store at -20 degree C
The antibody solution should be gently mixed before use.
Shelf life: ~12 months

Molecular Weight

349

OMIM

600366

3D Structure

ModBase 3D Structure for P61371

Immunogen

Recombinant full length protein of human Islet-1

Positive Control

WB: Hela; mouse thymus; rat thymus whole cell lysates, IF/ICC: A549 cells

Product Categories/Family for anti-Islet-1 antibody

Stem Cells; Neuroscience Antibodies

Applications Tested/Suitable for anti-Islet-1 antibody

Western Blot (WB), Immunofluorescence (IF)

Application Notes for anti-Islet-1 antibody

WB: 1:500-1:2000
IF: 1:50-1:200
ICC: 1:50-1:200

Other Notes

Small volumes of anti-Islet-1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Islet-1 purchase

MBS847495 is an antibody targeting Islet-1. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for Islet-1. It may not necessarily be applicable to this product.

NCBI GI #

47606423

NCBI GeneID

3670

NCBI Accession #

P61371.1

UniProt Primary Accession #

P61371

UniProt Secondary Accession #

P20663; P47894

UniProt Related Accession #

P61371

NCBI Official Full Name

Insulin gene enhancer protein ISL-1

NCBI Official Synonym Full Names

ISL LIM homeobox 1

NCBI Official Symbol

ISL1

NCBI Official Synonym Symbols

Isl-1; ISLET1

UniProt Protein Name

Insulin gene enhancer protein ISL-1

Protein Family

Insulin gene enhancer protein

UniProt Gene Name

ISL1

UniProt Synonym Gene Names

Islet-1

UniProt Entry Name

ISL1_HUMAN

NCBI Protein Information

insulin gene enhancer protein ISL-1; islet-1; ISL1 transcription factor, LIM/homeodomain

NCBI Summary for Islet-1

This gene encodes a member of the LIM/homeodomain family of transcription factors. The encoded protein binds to the enhancer region of the insulin gene, among others, and may play an important role in regulating insulin gene expression. The encoded protein is central to the development of pancreatic cell lineages and may also be required for motor neuron generation. Mutations in this gene have been associated with maturity-onset diabetes of the young. [provided by RefSeq, Jul 2008]

UniProt Comments for Islet-1

ISL1: Binds to one of the cis-acting domain of the insulin gene enhancer.

Protein type: Cell development/differentiation; Nuclear receptor co-regulator; DNA-binding; Transcription factor; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 5q11.1

Cellular Component: nucleoplasm; mitochondrion; cytoplasm; nucleus

Molecular Function: ligand-dependent nuclear receptor binding; zinc ion binding; bHLH transcription factor binding; estrogen receptor binding; chromatin binding

Biological Process: positive regulation of granulocyte macrophage colony-stimulating factor production; positive regulation of interleukin-12 production; positive regulation of interleukin-1 alpha production; negative regulation of transcription from RNA polymerase II promoter; positive regulation of tyrosine phosphorylation of Stat3 protein; negative regulation of estrogen receptor signaling pathway; pancreas development; positive regulation of cell proliferation; ventricular cardiac muscle morphogenesis; neuron fate specification; negative regulation of neuron apoptosis; sensory system development; neural crest cell migration; positive regulation of DNA binding; trigeminal nerve development; pharyngeal system development; axon regeneration; spinal cord motor neuron cell fate specification; positive regulation of insulin secretion; positive regulation of interleukin-6 production; spinal cord motor neuron differentiation; positive regulation of tumor necrosis factor production; positive regulation of interleukin-1 beta production; positive regulation of interferon-gamma production; negative regulation of neuron differentiation; positive regulation of angiogenesis; mesenchymal cell differentiation; visceral motor neuron differentiation; pituitary gland development; negative regulation of inflammatory response; positive regulation of transcription from RNA polymerase II promoter; peripheral nervous system neuron axonogenesis; retinal ganglion cell axon guidance

Research Articles on Islet-1

1. ISL1 is commonly expressed in rhabdomyosarcoma, particularly the alveolar subtype

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-Islet-1 antibody

Reference Product	PubMed Publications
MEF2C antibody	>17 publications with Islet-1 and MEF2C
SHH antibody	>15 publications with Islet-1 and SHH
BMP4 antibody	>12 publications with Islet-1 and BMP4
FGF10 antibody	>10 publications with Islet-1 and FGF10
INS antibody	>8 publications with Islet-1 and INS

Pathways associated with anti-Islet-1 antibody

Products by Pathway	Pathway Diagram
Cardiac Progenitor Differentiation Pathway antibodies	Cardiac Progenitor Differentiation Pathway Diagram
Heart Development Pathway antibodies	Heart Development Pathway Diagram
Incretin Synthesis, Secretion, And Inactivation Pathway antibodies	Incretin Synthesis, Secretion, And Inactivation Pathway Diagram
Metabolism Of Proteins Pathway antibodies	Metabolism Of Proteins Pathway Diagram
Neural Crest Differentiation Pathway antibodies	Neural Crest Differentiation Pathway Diagram
Peptide Hormone Metabolism Pathway antibodies	Peptide Hormone Metabolism Pathway Diagram
Signaling Pathways Regulating Pluripotency Of Stem Cells antibodies	Signaling Pathways Regulating Pluripotency Of Stem Cells Diagram
Signaling Pathways Regulating Pluripotency Of Stem Cells antibodies	Signaling Pathways Regulating Pluripotency Of Stem Cells Diagram
Synthesis, Secretion, And Inactivation Of Glucose-dependent Insulinotropic Polypeptide (GIP) Pathway antibodies	Synthesis, Secretion, And Inactivation Of Glucose-dependent Insulinotropic Polypeptide (GIP) Pathway Diagram

Diseases associated with anti-Islet-1 antibody

Disease Name	Pubmed Publications
Heart Diseases Antibodies	>36 publications with Islet-1 and Heart Diseases
Cardiovascular Diseases Antibodies	>35 publications with Islet-1 and Cardiovascular Diseases
Congenital Abnormalities Antibodies	>31 publications with Islet-1 and Congenital Abnormalities
Heart Defects, Congenital Antibodies	>24 publications with Islet-1 and Heart Defects, Congenital
Cardiovascular Abnormalities Antibodies	>22 publications with Islet-1 and Cardiovascular Abnormalities
Nervous System Diseases Antibodies	>10 publications with Islet-1 and Nervous System Diseases
Lung Neoplasms Antibodies	>5 publications with Islet-1 and Lung Neoplasms
Fibrosis Antibodies	>4 publications with Islet-1 and Fibrosis
Neoplasm Metastasis Antibodies	>4 publications with Islet-1 and Neoplasm Metastasis
Breast Neoplasms Antibodies	>4 publications with Islet-1 and Breast Neoplasms

Organs/Tissues associated with anti-Islet-1 antibody

Organ/Tissue Name	Pubmed Publications
Embryonic Tissue Antibodies	>120 publications with Islet-1 and Embryonic Tissue
Muscle Antibodies	>101 publications with Islet-1 and Muscle
Pancreas Antibodies	>62 publications with Islet-1 and Pancreas
Brain Antibodies	>53 publications with Islet-1 and Brain
Eye Antibodies	>43 publications with Islet-1 and Eye
Lung Antibodies	>11 publications with Islet-1 and Lung
Stomach Antibodies	>5 publications with Islet-1 and Stomach
Intestine Antibodies	>3 publications with Islet-1 and Intestine
Kidney Antibodies	>3 publications with Islet-1 and Kidney
Umbilical Cord Antibodies	>2 publications with Islet-1 and Umbilical Cord